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Add: bibcode. | Use this bot. Report bugs. | Suggested by Whoop whoop pull up | Category:Genes on human chromosome 19 | #UCB_Category 309/879
 
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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Underlinked|date=January 2017}}
{{Infobox_gene}}
{{Infobox_gene}}
'''NACHT, LRR and PYD domains-containing protein 4''' is a [[protein]] that in humans is encoded by the ''NLRP4'' [[gene]].<ref name="pmid12563287">{{cite journal |vauthors=Tschopp J, Martinon F, Burns K | title = NALPs: a novel protein family involved in inflammation | journal = Nat Rev Mol Cell Biol | volume = 4 | issue = 2 | pages = 95–104 |date=Feb 2003 | pmid = 12563287 | pmc = | doi = 10.1038/nrm1019 }}</ref><ref name="pmid12019269">{{cite journal |vauthors=Wang L, Manji GA, Grenier JM, Al-Garawi A, Merriam S, Lora JM, Geddes BJ, Briskin M, DiStefano PS, Bertin J | title = PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing | journal = J Biol Chem | volume = 277 | issue = 33 | pages = 29874–80 |date=Aug 2002 | pmid = 12019269 | pmc = | doi = 10.1074/jbc.M203915200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NLRP4 NLR family, pyrin domain containing 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=147945| accessdate = }}</ref>
'''NACHT, LRR and PYD domains-containing protein 4''' is a [[protein]] that in humans is encoded by the ''NLRP4'' [[gene]].<ref name="pmid12563287">{{cite journal |vauthors=Tschopp J, Martinon F, Burns K | title = NALPs: a novel protein family involved in inflammation | journal = Nat Rev Mol Cell Biol | volume = 4 | issue = 2 | pages = 95–104 |date=Feb 2003 | pmid = 12563287 | doi = 10.1038/nrm1019 | s2cid = 31417018 }}</ref><ref name="pmid12019269">{{cite journal |vauthors=Wang L, Manji GA, Grenier JM, Al-Garawi A, Merriam S, Lora JM, Geddes BJ, Briskin M, DiStefano PS, Bertin J | title = PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing | journal = J Biol Chem | volume = 277 | issue = 33 | pages = 29874–80 |date=Aug 2002 | pmid = 12019269 | doi = 10.1074/jbc.M203915200 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NLRP4 NLR family, pyrin domain containing 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=147945}}</ref>


NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003).[supplied by OMIM]<ref name="entrez" />
NALPs are [[Cytoplasm|cytoplasmic]] proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an [[N-terminus|N-terminal]] pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a [[C-terminus|C-terminal]] leucine-rich repeat (LRR) region.
The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a [[caspase recruitment domain]] (CARD). NALPs are implicated in the activation of [[proinflammatory]] caspases (e.g., [[CASP1]]; MIM 147678) via their involvement in multiprotein complexes called [[Inflammasome|inflammasomes]] (Tschopp et al., 2003).[supplied by OMIM]<ref name="entrez" />


==References==
==References==
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==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
*{{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
*{{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
*{{cite journal |vauthors=Damiano JS, Oliveira V, Welsh K, Reed JC |title=Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses |journal=Biochem. J. |volume=381 |issue= Pt 1 |pages= 213–9 |year= 2004 |pmid= 15107016 |doi= 10.1042/BJ20031506 | pmc=1133779 }}
*{{cite journal |vauthors=Damiano JS, Oliveira V, Welsh K, Reed JC |title=Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses |journal=Biochem. J. |volume=381 |issue= Pt 1 |pages= 213–9 |year= 2004 |pmid= 15107016 |doi= 10.1042/BJ20031506 | pmc=1133779 }}
*{{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki }}
*{{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-style=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki | doi-access=free }}
*{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}
*{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal | author=Grenier JM |title=Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1 |journal=FEBS Lett. |volume=530 |issue= 1–3 |pages= 73–8 |year= 2002 |pmid= 12387869 |doi=10.1016/S0014-5793(02)03416-6 |name-list-format=vanc| author2=Wang L | author3=Manji GA | display-authors=3 | last4=Huang | first4=W | last5=Algarawi | first5=A | last6=Kelly | first6=R | last7=Carlson | first7=A | last8=Merriam | first8=S | last9=Lora | first9=J }}
*{{cite journal | author=Grenier JM |title=Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1 |journal=FEBS Lett. |volume=530 |issue= 1–3 |pages= 73–8 |year= 2002 |pmid= 12387869 |doi=10.1016/S0014-5793(02)03416-6 |name-list-style=vanc| author2=Wang L | author3=Manji GA | display-authors=3 | last4=Huang | first4=W | last5=Algarawi | first5=A | last6=Kelly | first6=R | last7=Carlson | first7=A | last8=Merriam | first8=S | last9=Lora | first9=J |s2cid=25023390 }}
*{{cite journal | author=Fiorentino L |title=A novel PAAD-containing protein that modulates NF-kappa B induction by cytokines tumor necrosis factor-alpha and interleukin-1beta |journal=J. Biol. Chem. |volume=277 |issue= 38 |pages= 35333–40 |year= 2002 |pmid= 12093792 |doi= 10.1074/jbc.M200446200 |name-list-format=vanc| author2=Stehlik C | author3=Oliveira V | display-authors=3 | last4=Ariza | first4=ME | last5=Godzik | first5=A | last6=Reed | first6=JC }}
*{{cite journal | author=Fiorentino L |title=A novel PAAD-containing protein that modulates NF-kappa B induction by cytokines tumor necrosis factor-alpha and interleukin-1beta |journal=J. Biol. Chem. |volume=277 |issue= 38 |pages= 35333–40 |year= 2002 |pmid= 12093792 |doi= 10.1074/jbc.M200446200 |name-list-style=vanc| author2=Stehlik C | author3=Oliveira V | display-authors=3 | last4=Ariza | first4=ME | last5=Godzik | first5=A | last6=Reed | first6=JC | doi-access=free}}
{{refend}}
{{refend}}
{{NOD-like receptors}}
{{NOD-like receptors}}

Latest revision as of 17:49, 29 September 2022

NLRP4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNLRP4, CLR19.5, CT58, NALP4, PAN2, PYPAF4, RNH2, NLR family, pyrin domain containing 4, NLR family pyrin domain containing 4
External IDsOMIM: 609645; MGI: 1890518; HomoloGene: 75315; GeneCards: NLRP4; OMA:NLRP4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

147945

83564

Ensembl

ENSG00000160505

ENSMUSG00000034690

UniProt

Q96MN2

Q3TKR3

RefSeq (mRNA)

NM_134444

NM_031389

RefSeq (protein)

NP_604393

NP_113566

Location (UCSC)Chr 19: 55.84 – 55.88 MbChr 7: 6.05 – 6.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

NACHT, LRR and PYD domains-containing protein 4 is a protein that in humans is encoded by the NLRP4 gene.[5][6][7]

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region.

The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003).[supplied by OMIM][7]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160505 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034690 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tschopp J, Martinon F, Burns K (Feb 2003). "NALPs: a novel protein family involved in inflammation". Nat Rev Mol Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. S2CID 31417018.
  6. ^ Wang L, Manji GA, Grenier JM, Al-Garawi A, Merriam S, Lora JM, Geddes BJ, Briskin M, DiStefano PS, Bertin J (Aug 2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing". J Biol Chem. 277 (33): 29874–80. doi:10.1074/jbc.M203915200. PMID 12019269.
  7. ^ a b "Entrez Gene: NLRP4 NLR family, pyrin domain containing 4".

Further reading

[edit]


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