Thomas Payne (1718–1799) was a bookseller and publisher in London.
Thomas Payne or Tom may also refer to:
- Thomas Payn (fl. 1410–1437), MP for Melcombe Regis (UK Parliament constituency)
- Thomas Payne (MP for Gloucester) (fl. 1507–1560)
- Tom Payne, murder victim lynched in 1927, see Lynching of Tom Payne
- Thomas Payne (Australian politician) (1862–1932)
- Tom Payne (baseball) (fl. 1933), Negro league baseball player
- Tom Payne (director) (1914–1996), Brazilian film director
- Tom Payne (rugby league), footballer on the 1956 Australia national rugby league team
- Tom Payne (newsreader) (born 1943), Australian television newsreader
- Tom Payne (basketball) (born 1950), American basketball player
- Tony Payne (darts) (Thomas Anthony Payne born 1955), American darts player
- Tom Payne (theatre maker) (born 1979), British actor, satirist, theatre maker and environmental humanities academic
- Tom Payne (actor) (born 1982), English actor
- Thomas Payne (soldier) (born 1984), Medal of Honor recipient