Muriel Onslow (née Wheldale; 31 March 1880 – 19 May 1932) was a British biochemist, born in Birmingham, England. She studied the inheritance of flower colour in the common snapdragon Antirrhinum and the biochemistry of anthocyanin pigment molecules. She attended the King Edward VI High School in Birmingham and then matriculated at Newnham College, Cambridge in 1900. At Cambridge she majored in botany. Onslow later worked within Bateson's genetic group and then Frederick Gowland Hopkins biochemical group in Cambridge, providing her with expertise in biochemical genetics for investigating the inheritance and biosynthesis of petal colour in Antirrhinum.[1] She was one of the first women appointed as a lecturer at Cambridge, after moving to the Biochemistry department.[citation needed]
Muriel Onslow | |
|---|---|
 | |
| Born | Muriel Wheldale 31 March 1880 Birmingham, England |
| Died | 19 May 1932 (aged 52) Cambridge |
| Education | University of Cambridge |
| Known for | Inheritance of flower colour |
| Spouse | Victor Alexander Herbert Huia Onslow (died 1922) |
| Awards | Bathurst studentship (1904) |
| Scientific career | |
| Fields | Biochemistry, botany |
| Institutions | John Innes Horticultural Institution, University of Cambridge |
Education and personal life
editShe was the only child of her parents John and Fannie (née Hayward) Wheldale. Her father was a solicitor.[2] She attended King Edward VI High School in Birmingham, which was well known amongst single-sex schools for its strong science teaching to girls. In 1900, she entered Newnham College, Cambridge and achieved a First Class result in Part I of the Natural Sciences Tripos in 1902.[3][4] She took Part II (Botany) in 1904 and again achieved a First Class result but was not awarded a degree since University of Cambridge did not award degrees to women until 1948.[2][5]
In 1919 she married biochemist Victor Alexander Herbert Huia Onslow, second son of the 4th Earl of Onslow. They had no children. He had recently entered the field of chemical genetics, and their work was closely associated. Victor Onslow was paralysed from the waist down following a diving accident and died in 1922. In her memoir for her husband she wrote that he was a man of amazing courage and mental vitality enabling him to gain a career in biochemistry despite his physical circumstances, and with her encouragement and assistance.[6]
She died at her home in Cambridge on 19 May 1932, aged 52.[2]
Career
editHer work was funded initially by a Bathurst studentship in 1904 and then Newnham College fellowship for 6 years, starting in 1909.[6][2]
In 1903, she joined William Bateson's genetics group at Cambridge where she began her study focusing on the inheritance of petal colour in Antirrhinum (snapdragons). William Bateson was the English biologist who was the first person to use the term genetics to describe the study of heredity, and the chief populariser of the ideas of Gregor Mendel following their rediscovery in 1900. Bateson and Onslow, alongside a research group mainly made up of Newnham College graduates, carried out a series of breeding experiments in various plant and animal species between 1903 and 1910.[7]
By 1906, she had enough data to formulate a rudimentary factorial analysis on snapdragon inheritance. In 1907, Wheldale published a full explanation what became termed epistasis, the phenomenon of dominant-like relationship between different pairs of nonallelomorphic factors.[8] Wheldale's study of genetics on flower colouration ultimately gained her the most recognition, with the 1907 publication of a full factorial analysis of flower colour inheritance in snapdragons and the four subsequent papers she published from 1909 to 1910. Her interest was in the biochemistry underlying the petal colours, rather than understanding inheritance itself.[6] Her study of the chemistry of the anthocyanin pigments culminated in publication of her first book in 1916, The Anthocyanin Pigments of Plants.[9] This application of chemical analysis to explain genetic data led to international recognition since it was among the first attempts at syntheses of these two areas.[6]
She was an assistant lecturer in Newnham College between 1906 and 1908.[6]
She left Cambridge University between 1911 and 1914 owing to a studentship at the John Innes Horticultural Institution where, in addition to her laboratory work, she was valued as the Institution's leading botanical artist, able to capture the exact colours of plants.[10] In 1913, she became one of the first three women to be elected to the Biochemical Club (later to be known as the Biochemical Society) after the club's initial exclusion of women in 1911.[11]
She joined the biochemistry lab of Frederick Gowland Hopkins at Cambridge University in 1914, where she pursued the biochemical aspects of petal colour, whose genetics she had elucidated during her work with Bateson. She worked on oxidase systems which were also involved in additional areas of plant biology. This led her to work for the Food Investigation Board from 1917 onward and then, and from 1922 leading a team working on fruit ripening at the Cambridge Low Temperature Station from 1922.[6] Between 1917 and 1922 she collaborated with Victor Onslow on the colour and iridescence in insect scales.[2] In 1925 she produced a second, substantially revised edition of her book The Anthocyanin Pigments of Plants, updated for the substantial developments in the field since the first 1916 edition.[10]
In combining genetics and biochemistry she became one of the first biochemical geneticists and paved the way for the later successes of such seminal investigators as Edward Tatum and George Beadle.
In 1926, she was one of the first women appointed as a University Lecturer at Cambridge, in plant biochemistry in the biochemistry department. Students considered that she was an inspiring teacher and her course in plant biochemistry was an important part of the advanced botany curriculum.[2]
Amongst her followers was Rose Scott-Moncrieff who went on to identify the first crystalline form of primulin in about 1930. This was the first crystalline anthocyanin pigment ever identified. Onslow and Scott-Moncrieff have been credited with founding biochemical genetics, although Scott-Moncrieff is thought to have the stronger claim.[12]
Legacy
editThere is a prize and research fellowship named after her at Newnham College, University of Cambridge.[2]
In 2010 the Royal Institution of Great Britain staged a play, entitled Blooming Snapdragons, about four early-20th-century women biochemists, one of whom was Onslow. Written by Liz Rothschild and directed by Sue Mayo, it had been commissioned by the John Innes Centre where Onslow worked.[13]
Books by Muriel Onslow
edit- The Anthocyanin Pigments of Plants, 1916, revised in 1925
- Practical Plant Biochemistry, 1920
- Principles of Plant Biochemistry, Volume 1, 1931
References
edit- ^ Wheldale, M. (1 October 1914). "Our present knowledge of the chemistry of the Mendelian factors for flower-colour". Journal of Genetics. 4 (2): 109–129. doi:10.1007/BF02981834. ISSN 0022-1333. S2CID 31054499.
- ^ a b c d e f g Creese, Mary R S (2010). Onslow, Muriel Wheldale (1880–1932). Oxford Dictionary of National Biography.
- ^ College., Newnham. Newnham College register 1871–1950. 1924–1950. OCLC 271061932.
- ^ Ayres, Peter (2020). Women and the Natural Sciences in Edwardian Britain. In Search of Fellowship (1st ed.). London: Palgrave Macmillan. pp. 48–49. ISBN 978-3-030-46599-5.
{{cite book}}: CS1 maint: date and year (link) - ^ At Last a Degree of Honour for 900 Cambridge Women, Suzanna Chambers, 30 May 1998, The Independent. Retrieved July 2016.
- ^ a b c d e f Stephenson, Marjorie (1932). "Obituary Notice: Muriel Wheldale Onslow. 1880-1932". The Biochemical Journal. 26 (4): 915–916. doi:10.1042/bj0260915. PMC 1260991. PMID 16744946.
- ^ Richmond, Marsha L. (November 2007). "Opportunities for women in early genetics". Nature Reviews Genetics. 8 (11): 897–902. doi:10.1038/nrg2200. ISSN 1471-0056. PMID 17893692. S2CID 21992183.
- ^ Wheldale, Muriel (1907). "The Inheritance of Flower Colour in Antirrhinum Majus". Proc. R. Soc. B. 79 (532): 288–304. Bibcode:1907RSPSB..79..288W.
- ^ Wheldale, Muriel (1916). The Anthocyanin Pigments of Plants. University Press, Cambridge. OL 7120617M.
- ^ a b Rayner-Canham, Marelene; Rayner-Canham, Geoff (2002). "Muriel Wheldale Onslow (1880 –1932): pioneer plant biochemist". The Biochemist. April (2): 49–51. doi:10.1042/BIO02402049.
- ^ Trevor Walworth Goodwin (1987). History of the Biochemical Society : 1911–1986. The Biochemical Society. ISBN 0904498212. OCLC 716632236.
- ^ Cathie Martin, Rose Scott-Moncrieff and the dawn of (Bio) Chemical Genetics, Biochemist.org. Retrieved 5 July 2016.
- ^ Ferry, Georgina (2010). "Pioneers of plant genetics to flower on stage". Nature. 466 (188): 188. Bibcode:2010Natur.466..188F. doi:10.1038/466188a. S2CID 4336857.
External links
edit- Works by or about Muriel Onslow at the Internet Archive
- "Women Inspired by Marshall Ward" in Making British Botany [1]