Meptazinol (trade name Meptid) is an opioid analgesic developed by Wyeth in the 1970s.[1] Indications for use in moderate to severe pain, most commonly used to treat pain in obstetrics (childbirth). A partial µ-opioid receptor agonist, its mixed agonist/antagonist activity affords it a lower risk of dependence and abuse than full µ agonists like morphine. Meptazinol exhibits not only a short onset of action, but also a shorter duration of action relative to other opioids such as morphine, pentazocine, or buprenorphine.[2]
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| AHFS/Drugs.com | International Drug Names |
| Dependence liability | Low |
| Routes of administration | Oral, IM, IV |
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| Pharmacokinetic data | |
| Metabolism | The peak analgesic effect is seen within 30–60 minutes and lasts about 3–4 hours. |
| Elimination half-life | Half-Life (1.4–4 hours). |
| Excretion | The drug is rapidly metabolised to the glucuronide, and mostly excreted in the urine. |
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| ECHA InfoCard | 100.053.718 |
| Chemical and physical data | |
| Formula | C15H23NO |
| Molar mass | 233.34922 g/mol g·mol−1 |
| 3D model (JSmol) | |
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It does not appear in the US Controlled Substances Act 1970; it may or may not be regulated as an analogue of controlled relatives such as proheptazine (ACSCN 9643)
References
- ^ US patent 4197239, Cavalla JF, Shepherd RG, White AC, "Hexahydroazepine, Piperidine and Pyrrolidine Derivatives", issued 1980-04-08, assigned to Wyeth
- ^ Holmes B, Ward A (1985). "Meptazinol. A Review of its Pharmacodynamic and Pharmacokinetic Properties and Therapeutic Efficacy". Drugs. 30 (4): 285–312. doi:10.2165/00003495-198530040-00001. PMID 2998723.
External links
- Meptazinol at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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