Kahweol is a diterpene molecule found in the beans of Coffea arabica. It is structurally related to cafestol.
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IUPAC name
(3bS,5aS,7R,8R,10aR,10bS)-3b,4,5,6,7,8,9,10,10a,10b-Decahydro-7-hydroxy-10b-methyl-5a,8-Methano-5aH-cyclohepta(5,6)naphtho(2,1-b)furan-7-methanol
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3D model (JSmol)
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PubChem CID
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CompTox Dashboard (EPA)
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Properties | |
C20H26O3 | |
Molar mass | 314.42 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Recent research suggests that kahweol may have beneficial effects on bone by inhibiting osteoclast differentiation.[1] Another recent study confirmed that kahweol has anti-inflammatory and anti-angiogenic effects, offering a possible mechanism for the association found in epidemiological studies between consumption of unfiltered coffee and decreased risk of cancer.[2]
References
- ^ "The Coffee Diterpene Kahweol Prevents Osteoclastogenesis via Impairment of NFATc1 Expression and Blocking of Erk Phosphorylation". J Pharmacol Sci. 23. Mar 2012. doi:10.1254/jphs.11212FP. PMID 22447306.
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ignored (help) - ^ "Anti-angiogenic and anti-inflammatory properties of kahweol, a coffee diterpene". PLoS One. 6. Aug 2011. doi:10.1371/annotation/38262cc6-07cc-4074-8ce7-2181d4d0fbdc. PMID 21858104.
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ignored (help)CS1 maint: unflagged free DOI (link)