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==Pharmacology==
=== Mechanism of action ===
Artemether is an [[artemisinin]] derivative and the mechanism of action for artemisinins is.{{mcn|date=April 2020}}
Artemether interact with ferriprotoporphyrin IX (heme) or ferrous ions in the acidic parasite food vacuole, and generates cytotoxic radical species {{mcn|date=April 2020}}
The accepted mode of action of the peroxide containing drug involve its interaction with heme (byproduct of hemoglobin degradation), derived from proteolysis of haemoglobin. This interaction results in the formation of toxic oxygen and carbon centered radicals.{{mcn|date=April 2020}}
One of the proposed mechanisms is that through inhibiting anti-oxidant and metabolic enzymes, artemisinin derivatives inflict oxidative and metabolic stress on the cell. Some pathways affected may concern glutathione and glucose metabolism. As a consequence, lesions and reduced growth of the parasite may result.<ref name=Saeed2016>{{cite journal|last1=Saeed|first1=ME|last2=Krishna|first2=S|last3=Greten|first3=HJ|last4=Kremsner|first4=PG|last5=Efferth|first5=T|title=Antischistosomal activity of artemisinin derivatives in vivo and in patients.|journal=Pharmacological Research|date=August 2016|volume=110|pages=216–26|pmid=26902577|doi=10.1016/j.phrs.2016.02.017}}</ref>
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