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Guzzolini was sent in 1197 to learn [[jurisprudence]] in [[University of Bologna|the college]] at [[Bologna]] (for law) and [[University of Padua|the college]] in [[Padua]] but felt called to the ecclesiastical state (finding no satisfaction in his studies and deeming them too secular) and abandoned his studies in law for [[Theology|theological]] and [[Holy Scripture|scriptural]] studies.<ref name=SEB/> On his return home in 1208 it is said that his father – angered at his change of purpose – refused to speak to him for one decade.<ref name=NA/><ref name=SQPN/> Guzzolini accepted a position as a [[Canon (priest)|canon]] at Osimo (after the diocesan bishop [[ordained]] him in 1217) and devoted himself to pastoral work with such zeal as to arouse hostilities from his bishop whom he had rebuked with respect for the scandals that the prelate's irregular life had caused.<ref name=BT/>
The prelate threatened to strip him of his position but the canon decided to leave the world upon seeing the corpse of one who had once been noted for their looks while presiding over a funeral.<ref name=SEB/> He retired to a desert place far from Osimo in 1227 and lived there in strict poorness until the owner of the land – the nobleman Corrado – recognized him and offered him a better site for his hermitage. The dampness drove him from that place and he established himself next at Grotta Fucile where he later built a [[convent]] for his future [[religious order]]. In this place his penances were most severe for he lived on raw herbs and water and slept on the bare ground.<ref name=BT/><ref name=NA/> Disciples flocked to him seeking his direction and it became vital for him to choose a Rule. His fame worried [[Pope Gregory IX]] in 1228 and he decided to
On 27 June 1248 he obtained from [[Pope Innocent IV]] a [[papal bull]] confirming his order as being canonical and before his death founded eleven monasteries after this approval.<ref name=BT/><ref name=SEB/> He died on 26 November 1267 due to a severe [[fever]]; Doctor Andrea embalmed him and the room was filled with a sweet fragrance when he removed Guzzolini's [[bowels]].<ref name=SEB/> His remains were later disinterred and placed in a shrine still present at the church of Monte Fano.<ref name=NA/>
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