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==Biography==
Born in [[Joinville, Haute-Marne]], Charles of Guise was the son of [[Claude, Duke of Guise]] and his wife [[Antoinette de Bourbon]]. His older brother was [[François, Duke of Guise]]. His sister [[Mary of Guise]] was wife of [[James V of Scotland]] and mother of [[Mary, Queen of Scots]]. He was made [[Archbishop of Reims]] in 1538,<ref>Guise's bulls were granted by [[Pope Paul III]] on 6 February 1538, according to the ''Acta Consistorialia'': {{cite book|author=Conradus Eubel (ed.)|last2=Gulik|first2=Guilelmus|title=Hierarchia catholica, Tomus 3|date=1923|publisher=Libreria Regensbergiana|location=Münster|edition=second|url=https://archive.org/details/hierarchiacathol02eubeuoft|page=285}}</ref> Cardinal on 27 July 1547<ref>Eubel,
The efforts of this cardinal to enforce his family's pretensions to the [[Count of Provence|Countship of Provence]], and his temporary assumption, with this object, of the title of Cardinal of Anjou were without success. He failed also when he attempted, in 1551, to dissuade Henry II from uniting the [[Duchy of Lorraine]] to France. He succeeded, however, in creating for his family interests certain political alliances that occasionally seemed in conflict with each other. He coquetted for instance on the one hand with the Lutheran princes of Germany, and on the other his interview (1558) with the [[Cardinal de Granvelle]] (at Péronne) initiated friendly relations between the Guises and the royal house of Spain.
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