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==Botanical expedition==
Beginning in 1763, Mutis proposed to the king that he sponsor an expedition to study the flora and fauna of the region. He had to wait 20 years for the authorization, but in 1783 the king authorized his expedition (one of three royal botanical expeditions to the New World at about that time). In the interim, Mutis concentrated on commercial and mineralogical projects, not neglecting medicine. He also studied the social and economic conditions of the viceroyalty, and continued to expand his collection of flora and fauna. On 19 December 1772 he was ordained a priest. He was in regular correspondence with scientists in Spain and elsewhere in Europe, particularly [[Carolus Linnaeus]].
Mutis led the Royal Botanical Expedition, established in 1783, for 25 years. It explored some 8,000 km<sup>2</sup> in a range of climates, using the [[Río Magdalena]] for access to the interior. He developed a meticulous methodology that included the harvesting of the samples in the field together with detailed descriptions, including data on the surroundings of each species and its utility. Hundreds of plants were discovered and described. More than 8,000 plates, plus maps, correspondence, notes and manuscripts were sent to Spain. His museum consisted of 24,000 dried plants, 5,000 drawings of plants by his pupils, and a collection of woods, shells, resins, minerals, and skins. These treasures arrived safely at Madrid in 105 boxes, and the plants, manuscripts, and drawings were sent to the botanical gardens, where they were relegated to a tool-house.
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