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==Work in Guyana==
Between 1994 and 2012, Silverman travelled to [[Guyana]] to lead medical teams offering free medical treatment to the country's residents when their health system was not able to serve those in remote communities.<ref>{{cite news|title=Toronto Jews take to streets and the Guyana rainforests to serve those in need|url=https://www.jweekly.com/2001/04/20/toronto-jews-take-to-streets-and-the-guyana-rainforests-to-serve-those-in-n/|publisher=The Jewish News of Northern California|date=20 April 2001}}</ref> For the first few years Silverman's work was accomplished through Ve'ahavta, a Jewish humanitarian organization based out of Toronto. He was the original director of medical operations with the organization.
Silverman demonstrated that the high prevalence of [[malaria]] in some regions of Guyana was leading to widespread use of antimalarial drugs, which then caused bacteria to become resistant to important antibiotics ([[Quinolone antibiotic|the quinolones]]). Malarial control using bednets and other non-antibiotic means could then help prevent the loss of utility of these antibiotics.<ref>{{cite journal|title=Malaria drug may hit antibiotics|journal=BBC|url=http://news.bbc.co.uk/2/hi/health/7506965.stm/}}</ref><ref>{{cite journal|last1=Juncosa|first1=Barbara|title=Antibiotic Resistance: Blame It on Lifesaving Malaria Drug?|journal=Scientific American|date=21 July 2008|url=https://www.scientificamerican.com/article/antibiotic-resistance-blame-it-on-lifesaving-malaria-drug/}}</ref>
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== Work in Africa==
Silverman’s research in [[Africa]] into the use of a [[HAART regimen]] during pregnancy and breastfeeding showed that it appeared to significantly prevent the transmission of [[HIV]] from mothers to infants.<ref>{{cite journal|last1=Thistle|first1=Paul|last2=Bolotin|first2=Shelly|last3=Lam|first3=Eugene|last4=Schwarz|first4=Dan|last5=Pilon|first5=Richard|last6=Ndawana|first6=Billy|last7=E Simor|first7=Andrew|last8=Silverman|first8=Michael|title=Highly active anti-retroviral therapy in the prevention of mother-to-child transmission of HIV in rural Zimbabwe during the socio-economic crisis|journal=Medicine, Conflict
Silverman worked in Africa to treat mothers during pregnancy and their newborn babies noting that treatment for H.I.V., syphilis, malaria and high blood pressure, can make enormous differences in whether mother and baby survive the birth. Many African women relied on traditional healers during pregnancy and only went to clinics during labour. In order to entice them to visit doctors during pregnancy, he instituted a program of ultrasounds with the promise that the women could see their unborn baby. This was a tremendous incentive and caused a jump in antenatal clinic visits by pregnant women.<ref>{{cite news|last1=McNeil Jr.|first1=Donald G.|title=In Africa, Rural Clinics Entice Pregnant Women With 'Baby Pictures'|url=https://www.nytimes.com/2017/11/10/health/africa-clinics-ultrasounds-women.html|accessdate=10 November 2017|work=The New York Times}}</ref>
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== Fecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial ==
In a world-first clinical trial published in the journal ''[[Nature Medicine]]'',<ref>{{Cite web |title=Fecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial |url=https://www.nature.com/articles/s41591-023-02453-x |website=Nature Medicine}}</ref> a multi-centre study from [[Lawson Health Research Institute]], the [[Centre hospitalier de l'Université de Montréal]] (CHUM) and the [[Jewish General Hospital]] (JGH) has found [[
==Treatment of metabolic disease and weight gain with fecal transplantation==
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"This is important because one hypothesis for how an abnormal microbiome could contribute to metabolic disease and weight gain is by damaging the gut barrier that keeps toxins and pathogens from crossing into the bloodstream. When this occurs, it can set off a cascade of inflammation, contributing to insulin resistance, cardiovascular disease and autoimmune conditions, said Dr. Michael Silverman, the lead author of the study and the chairman of infectious diseases at Western University in Ontario”, the New York Times reported.<ref>{{cite news|last1=O’Connor|first1=JAnahad|title=Seeking an Obesity Cure Researchers Turn to the Gut Microbiome|url=https://www.nytimes.com/2019/09/10/well/eat/seeking-an-obesity-cure-researchers-turn-to-the-gut-microbiome.html?smid=nytcore-ios-share|work=New York Times|date=10 September 2008}}</ref>
== Work to protect injection drug Users from infection ==
Silverman is involved in trying to reduce the incidence of life-threatening infections such as HIV, [[hepatitis]] and [[endocarditis]] (a heart valve infection) in people who inject drugs.<ref name=":0">{{Cite web |date=May 3, 2019 |title=Note to Harm Reduction Programs and Staff Regarding Recent HIV Research and 'Cook Your Wash' |url=https://www.catie.ca/sites/default/files/ohrdp-ohrn-note-findings-05032019.pdf |website=catie.ca}}</ref>
He demonstrated that the sharing of equipment used to inject drugs could help to spread HIV and Hepatitis C. The reuse of the equipment could also help to lead to bacterial contamination and then endocarditis, an infection with a high mortality. He demonstrated that this was especially problematic when long acting opiates were used.<ref>{{Cite journal |last1=Silverman |first1=Michael |last2=Slater |last3=Jandoc |last4=Garg |last5=Weir |date=January 22,
Silverman also showed that starting addiction counselling while in hospital (as opposed to after their release) for persons who inject drugs with heart valve [[
==Awards==
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