In connection to his feud with Ja Rule, 50 Cent also took aim at fellow New York rapper [[Fat Joe]], a high profile collaborator of Ja Rule's.<ref>{{cite web|url=https://www.complex.com/music/a/jaelaniturnerwilliams/50-cent-fat-joe-christmas-new-york-knicks|title=50 Cent and Fat Joe Seated Next to Each Other During Christmas New York Knicks Game|website=[[Complex Networks]] }}</ref><ref>{{citeCite web|url=https://www.revolt.tv/article/2023-02-10/272594/50-cent-regrets-dragging-fat-joe-into-ja-rule-beef|title=50 Cent regrets dragging Fat Joe into Ja Rule beef|first=DJ First|last=Class|website=Revolt.tv}}</ref> The feud took aim at Fat Joe following his 2002 track [[What's Luv?]] featuring Ja Rule and [[Ashanti (singer)|Ashanti]]. Fat Joe had also continued his collaboration with [[Murder Inc. (rap group)|Murder Inc.]] on his 2004 track "New York" featuring [[Jadakiss]], prompting a diss track aimed at Fat Joe from 50 Cent on his 2005 album [[The Massacre]] entitled [[Piggy Bank (song)|Piggy Bank]]. Fat Joe later responded with the track "My Fofo" on his album [[All or Nothing (Fat Joe album)|All or Nothing]] released later that same year. Tensions boiled over during the [[2005 MTV Video Music Awards]] when Fat Joe presented the award for best Hip Hop Video, in which he told the audience "I feel so safe tonight with all this police protection courtesy of [[G-Unit]]". 50 Cent later retaliated with a profanity-laden diatribe following his performance of the song [[So Seductive]] with fellow G-Unit artist [[Tony Yayo]], exclaiming "Fat Joe's a pussy man! [...] Pussy Boy, Nigga What?!". The feud later affected Fat Joe financially as he sought to secure a $20 million contract endorsing [[Air Jordan]] sneakers in early 2005, [[Michael Jordan]] himself later cancelled the contract following the VMA incident as he was in fear of conflict with 50 Cent or any other affiliates.<ref>{{cite web|url=https://www.gq.com/story/fat-joe-book-of-jose-memoir-50-cent-g-unit-beef|title=Fat Joe on the VMAs Dust-Up with 50 Cent That Cost Him $20 Million|date=November 14, 2022 }}</ref> Following this; little action was taken on either side as the feud seemed to calm down by 2011. Murder Inc. executive [[Irv Gotti]] later expressed anger at Fat Joe following his proposal to quell their longstanding feud with G-Unit in 2010.<ref>{{cite web|url=https://www.youtube.com/watch?v=vI1LqJY_E5M|title=Irv Gotti Cussed Out Fat Joe for Trying to Squash Their Beef with 50 Cent (Flashback)|website=[[YouTube]] |date=August 21, 2023 }}</ref> In 2012; 50 Cent approached Fat Joe in talks of ending the feud following the two agreeing to perform at a memorial ceremony for then recently-deceased music executive [[Chris Lighty]].<ref>{{cite web|url=https://www.youtube.com/watch?v=mFYE8yd_w5I|title=Fat Joe on Ending 50 Cent Beef: We Did What Israel and Palestine Couldn't (Flashback)|website=[[YouTube]] |date=July 29, 2023 }}</ref> Despite the prior history between the two, 50 Cent and Fat Joe became close friends and business associates shortly thereafter despite Fat Joe's lengthy connections with Ja Rule.<ref>{{cite web|url=https://hiphopdx.com/news/fat-joe-50-cent-beef-new-york-suge-knight|title=FAT JOE SALUTES 50 CENT FOR BEEFING WITH HIM: 'I HAD THE PERSONA OF NEW YORK SUGE KNIGHT'|date=July 29, 2023 }}</ref><ref>{{citeCite web|url=https://www.revolt.tv/article/2023-10-11/329761/fat-joe-admits-50-cent-has-one-of-the-greatest-albums-of-all-time|title=Fat Joe admits 50 Cent's'Get Rich or Die Tryin'{{-'}} ishas one of the greatest albums of all time despite past beef|first=Oumou|last=Fofana|website=Revolt.tv}}</ref>
