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In the simplified view of this pathway HSPs are usually not mentioned: antigenic peptides are generated in [[proteasome]], transported into [[Endoplasmic reticulum|ER]] through protein transporter [[Transporter associated with antigen processing|TAP]] and loaded onto [[MHC class I|MHCI]], which then goes through [[secretory pathway]] on plasma membrane.
But HSPs play an important part in transfer of unfolded proteins to [[proteasome]] and generated peptides to [[MHC class I|MHCI]].<ref name="Binder_2014" /> [[Hsp90]] can associate with [[proteasome]] and take over generated peptides. Afterwards, it can associate with [[hsp70]], which can take the peptide further to the [[Transporter associated with antigen processing|TAP]]. After passing through TAP,
This handing over with peptides is important, because HSPs can shield hydrophobic residues in peptides which would be otherwise problematic in aquatic cytosol. Also simple diffusion of peptides would be too ineffective.<ref name="Binder_2014" />
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