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Dmitry Nilov (talk | contribs) |
Dmitry Nilov (talk | contribs) |
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PARP1 works:
* By using [[Nicotinamide adenine dinucleotide|NAD+]] to synthesize poly [[Adenosine diphosphate ribose|ADP ribose]] (PAR) and transferring PAR [[Moiety (chemistry)|moieties]] to proteins ([[ADP-ribosylation]]).<ref>{{cite journal | pmid = 32079521 | year = 2020 | last1 = Nilov | first1 = DK | last2 = Pushkarev | first2 = SV | last3 = Gushchina | first3 = IV | last4 = Manasaryan | first4 = GA | last5 = Kirsanov | first5 = KI | last6 = Švedas | first6 = VK | title = Modeling of the enzyme-substrate complexes of human poly(ADP-ribose) polymerase 1 | volume = 85 | pages = 99-107 | journal = Biochemistry (Mosc.) | doi=10.1134/S0006297920010095}}</ref>
* In conjunction with BRCA, which acts on double strands; members of the [[Poly ADP ribose polymerase|PARP]] family act on single strands; or, when BRCA fails, PARP takes over those jobs as well (in a DNA repair context).
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