Mayilsamy died from a [[cardiac arrest]] in Chennai, in the early morning on 19 February 2023, at the age of 57.<ref>{{Cite web |date=2023-02-19 |title=Popular Tamil comedian Mayilsamy dies at 57, Kamal Haasan says he had his 'own style' |url=https://www.businesstoday.in/latest/trends/story/popular-tamil-comedian-mayilsamy-dies-at-57-kamal-haasan-says-he-had-his-own-style-370740-2023-02-19 |access-date=2023-02-19 |website=Business Today |language=en}}</ref><ref>{{Cite news |date=19 February 2023 |title=Kollywood mourns the demise of actor Mayilsamy |work=The Times of India |url=https://timesofindia.indiatimes.com/entertainment/tamil/movies/news/kollywood-mourns-the-demise-of-actor-mayilsamy/articleshow/98056433.cms?from=mdr |access-date=19 February 2023 |issn=0971-8257}}</ref>
OnIn the evening of 18 February, Mayilsamy had attended a [[Shivratri]] Puja at Sri Meghnad Eswarar temple in Kelambakkam, Chennai. He then called [[Drums Sivamani]] to conduct a special musical session in the temple, which occuredoccurred at around 11 PM.<ref>{{cite news |title=Mayilsamy's sons clear the rumours about their father's death |url=https://timesofindia.indiatimes.com/entertainment/tamil/movies/news/mayilsamys-sons-clear-the-rumours-about-their-fathers-death/photostory/98198599.cms |work=The Times of India}}</ref> He was returning back home temple when he suffered a cardiac arrest. He was immediately rushedtaken to a localnearby hospital in an auto-rickshaw. The doctors declared him brought dead.<ref name="cremated">{{cite news |title=Comedy King Mayilsamy's body was cremated... |url=https://www.indiaherald.com/Breaking/Read/994574518/Comedy-King-Mayilsamys-body-was-cremated |work=indiaherald.com |language=en}}</ref>
FuneralHis funeral was conducted at his home. He was cremated at AVM cemetery in Vadapalani on 20 February.<ref name="cremated" />
