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Intro already says it's the most common type |
ClueBot NG (talk | contribs) m Reverting possible vandalism by 2600:1700:8392:6270:DCAF:FA75:A134:BEAE to version by WOSlinker. Report False Positive? Thanks, ClueBot NG. (4350241) (Bot) |
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It does this through several mechanisms:{{cn|date=January 2023}}
* IgG-mediated binding of pathogens causes their immobilization and binding together via [[agglutination (biology)|agglutination]]; IgG coating of pathogen surfaces (known as [[opsonization]]) allows their recognition and ingestion by [[phagocytosis|phagocytic immune cells]] leading to the elimination of the pathogen itself;
* IgG activates
* IgG also binds and [[neutralisation (immunology)|neutralizes]] [[toxin]]s;
* IgG also plays an important role in [[antibody-dependent cell-mediated cytotoxicity]] (ADCC) and [[intracellular antibody-mediated proteolysis]], in which it binds to [[TRIM21]] (the receptor with greatest affinity to IgG in humans) in order to direct marked virions to the [[proteasome]] in the cytosol;<ref name="pmid21045130">{{cite journal |vauthors=Mallery DL, McEwan WA, Bidgood SR, Towers GJ, Johnson CM, James LC |title=Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21) |journal=Proceedings of the National Academy of Sciences, USA |volume=107 |issue=46 |pages=19985–19990 |year=2010 |pmid=21045130 |doi=10.1073/pnas.1014074107 |pmc=2993423|bibcode=2010PNAS..10719985M |doi-access=free }}</ref>
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{| class="wikitable"
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| [[IGHG1|IgG1]] || 66% || yes (1.47)* || second-highest || high affinity || 21 days
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