Kahweol: Difference between revisions

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'''Kahweol''' is a [[diterpenoid]] molecule found in the beans of ''[[Coffea arabica]]''. Itand is structurally related to [[cafestol]].<ref Itname="Surma">{{cite getsjournal its| namelast=Surma from| thefirst=S. Arabic| wordlast2=Oparil "Ka-ah-wa"| first2=S. | title=Coffee and Arterial Hypertension | journal=Current Hypertension Reports| volume=23 | issue=7 | date=August 9, from2021 which| "coffee"issn=1522-6417 derives| pmid=34370111 | pmc=8352830 | doi=10.1007/s11906-021-01156-3 In| French,page=38}}</ref> it'sIts evolvedname intoderives from the slang[[Arabic]] word{{lang|ar|قهوة}} "kawa",{{transliteration|ar|qahwa}} to designatemeaning "coffee".
 
Recent research suggests that kahweol may have beneficial effects on bone by inhibiting [[osteoclast]] [[cellular differentiation|differentiation]].<ref>{{cite journal |doi=10.1254/jphs.11212FP |authors= Fumimoto R, Sakai E, Yamaguchi Y, Sakamoto H, Fukuma Y, Nishishita K, Okamoto K, Tsukuba T |title=The Coffee Diterpene Kahweol Prevents Osteoclastogenesis via Impairment of NFATc1 Expression and Blocking of Erk Phosphorylation. |journal=J Pharmacol Sci |date=Mar 2012 |volume= 118|pmid=22447306 |issue=4 |pages=479–86|doi-access=free }}</ref> Another recent study confirmed that kahweol has [[anti-inflammatory]] and [[anti-angiogenic]] effects, offering a possible mechanism for the association found in epidemiological studies between consumption of unfiltered coffee and decreased risk of cancer.<ref>{{cite journal |doi=10.1371/JOURNAL.PONE.0023407 |authors= Cárdenas C, Quesada AR, Medina MA |title=Anti-angiogenic and anti-inflammatory properties of kahweol, a coffee diterpene. |journal=PLOS ONE |date=Aug 2011 |volume=6 |pmid=21858104 |issue=8 |pmc=3153489 |pages=e23407|bibcode= 2011PLoSO...623407C }} {{open access}}</ref>
 
== See also ==
* [[Cafestol]]
* [[Health effects of coffee]]
* [[List of chemical compounds in coffee]]
 
== References ==