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Kulldorff was a member of the Vaccine Safety Technical subgroup of CDC’s Advisory Committee on Immunization Practices.<ref name="Bloomberg-JnJ">{{Cite web|last=Peebles|first=Angelica|date=April 21, 2021|title=J&J Shot's Future Depends on 15 Cautious Vaccine Experts|url=https://www.bloomberg.com/news/articles/2021-04-21/j-j-shot-s-u-s-future-depends-on-15-cautious-vaccine-experts|url-access=subscription|access-date=September 2, 2021|website=[[Bloomberg News|Bloomberg]]}}</ref> In April 2021, he disagreed with the CDC's pause of the [[Janssen COVID-19 vaccine|Johnson & Johnson vaccine]] rollout and argued publicly that the vaccine's benefits outweighed clotting risks, particularly for older people.<ref name="Bloomberg-JnJ" /><ref>{{Cite web|last=Kulldorff|first=Martin|date=April 17, 2021|title=The dangers of pausing the J&J vaccine|url=https://thehill.com/opinion/healthcare/548817-the-dangers-of-pausing-the-jj-vaccine|access-date=January 16, 2022|website=[[The Hill (newspaper)|The Hill]]|language=en|quote=Unfortunately, the recent "pause" on using the Johnson & Johnson vaccine will dampen the impact of this success.}}</ref>
In December 2021, Kulldorff published an essay for the [[Brownstone Institute]] in which he argued against children receiving vaccination against COVID-19, falsely claiming that [[influenza]] was a greater risk to children than COVID-19.<ref name="saves" /> In a critical response published in [[Science-Based Medicine]], Jonathan Howard noted errors and factual inaccuracies in Kulldorff's essay, pointing out that while influenza was responsible for only one child death in the 2020/21 season – while [[public health mitigation of COVID-19]] was in place – COVID-19 killed more than 1,000.<ref name=saves>{{cite web |publisher=[[Science-Based Medicine]] |title=I Disagree With an Article Called 'Vaccines Save Lives' |vauthors=Howard J |date=23 December 2021 |url=https://sciencebasedmedicine.org/i-disagree-with-an-article-called-vaccines-save-lives/}}</ref> In addition to this, Kulldorff's essay omitted that children who are infected with COVID-19 are at risk for rare but serious conditions, such as [[Multisystem inflammatory syndrome in children|MIS-C]], with 8,862 confirmed cases of children with MIS-C by March of 2023.<ref name=saves/><ref name="Maltz-Matyschsyk2023">{{cite journal |last1=Maltz-Matyschsyk |first1=Michele |last2=K. Melchiorre |first2=Clare |last3=Herbst |first3=Katherine W. |last4=Hogan |first4=Alexander H. |last5=Dibble |first5=Kristina |last6=O'Sullivan |first6=Brandon |last7=Graf |first7=Joerg |last8=Jadhav |first8=Aishwarya |last9=Lawrence |first9=David A. |last10=Lee |first10=William T. |last11=J. Carson |first11=Kyle |last12=Radolf |first12=Justin D. |last13=C. Salazar |first13=Juan |last14=Lynes |first14=Michael A. |title=Development of a biomarker signature using grating-coupled fluorescence plasmonic microarray for diagnosis of MIS-C |journal=Frontiers in Bioengineering and Biotechnology |date=31 March 2023 |volume=11 |doi=10.3389/fbioe.2023.1066391 |doi-access=free |pmid=37064248 |pmc=10102909 }}</ref>
On 13 February 2022, Kulldorff tweeted in support of the [[Canada convoy protest]],<ref>{{Cite web |last=Butler |first=Kiera |date=February 15, 2022 |title=These doctors' groups are cheering on the anti-vax truckers |url=https://www.motherjones.com/politics/2022/02/ottawa-convoy-protest-promoters-elite-medical-credentials-financial-incentives-astroturf-libertarian/ |access-date=March 4, 2022 |website=[[Mother Jones (magazine)|Mother Jones]] |language=en-US}}</ref> which was organized to protest against vaccine mandates and other government restrictions regarding COVID-19.<ref>{{Cite web |last1=Woods |first1=Michael |last2=Pringle |first2=Josh |date=January 27, 2022 |title=Truck convoy rolls into Kingston, Ont. |url=https://ottawa.ctvnews.ca/truck-convoy-rolls-into-kingston-ont-1.5756220 |access-date=March 5, 2022 |website=CTV News Ottawa |language=en}}</ref> In December 2022, Florida Gov. DeSantis named Kulldorff, Bhattacharya, and several other opponents of the scientific consensus on COVID-19 vaccines to his newly formed Public Health Integrity Committee to "offer critical assessments" of recommendations from federal health agencies.<ref>{{Cite web |last=Catherman |first=Caroline |date=2022-12-13 |title=DeSantis announces grand jury to investigate 'wrongdoing' around COVID-19 vaccines |url=https://www.orlandosentinel.com/coronavirus/os-ne-coronavirus-desantis-grand-jury-covid-vaccines-ladapo-research-20221213-owp55jm45bayzmpwvp3wel6f6y-story.html |access-date=2022-12-13 |website=[[Orlando Sentinel]] |language=en-US}}</ref>
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