CERN Accelerating science

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1.
An experimental study of focused very high energy electron beams for radiotherapy / Kokurewicz, Karolina (Glasgow U.) ; Brunetti, Enrico (Glasgow U.) ; Curcio, Alessandro (CERN) ; Gamba, Davide (CERN) ; Garolfi, Luca (CERN) ; Gilardi, Antonio (CERN ; U. Naples (main) ; INFN, Naples) ; Senes, Eugenio (CERN ; JAI, UK) ; Sjobak, Kyrre Ness (CERN ; U. Oslo (main)) ; Farabolini, Wilfrid (CERN ; U. Paris-Saclay) ; Corsini, Roberto (CERN) et al.
Very high energy electron (VHEE) beams have been proposed as an alternative radiotherapy modality to megavoltage photons; they penetrate deeply without significant scattering in inhomogeneous tissue because of their high relativistic inertia. However, the depth dose distribution of a single, collimated VHEE beam is quasi-uniform, which can lead to healthy tissue being overexposed. [...]
2021 - 7 p. - Published in : Commun. Phys. 4 (2021) 33 Fulltext: PDF;
2.
CERN-based experiments and Monte-Carlo studies on focused dose delivery with very high energy electron (VHEE) beams for radiotherapy applications / Whitmore, L (Manchester U. ; Cockcroft Inst. Accel. Sci. Tech. ; Texas U., Houston) ; Mackay, R I (Manchester U.) ; van Herk, M (Manchester U.) ; Korysko, P (Oxford U. ; CERN) ; Farabolini, W (CERN) ; Malyzhenkov, A (CERN) ; Corsini, R (CERN) ; Jones, R M (Manchester U. ; Cockcroft Inst. Accel. Sci. Tech.)
Very High Energy Electron (VHEE) beams are a promising alternative to conventional radiotherapy due to their highly penetrating nature and their applicability as a modality for FLASH (ultra-high dose-rate) radiotherapy. The dose distributions due to VHEE need to be optimised; one option is through the use of quadrupole magnets to focus the beam, reducing the dose to healthy tissue and allowing for targeted dose delivery at conventional or FLASH dose-rates. [...]
2024 - 15 p. - Published in : Sci. Rep. 14 (2024) 11120 Fulltext: PDF;
3.
Influence of heterogeneous media on Very High Energy Electron (VHEE) dose penetration and a Monte Carlo-based comparison with existing radiotherapy modalities / Lagzda, Agnese (Manchester U. ; Cockcroft Inst. Accel. Sci. Tech.) ; Angal-Kalinin, Deepa (Cockcroft Inst. Accel. Sci. Tech. ; Daresbury) ; Jones, James (Cockcroft Inst. Accel. Sci. Tech. ; Daresbury) ; Aitkenhead, Adam (Unlisted, UK ; Manchester U.) ; Kirkby, Karen J (Unlisted, UK ; Manchester U.) ; MacKay, Ranald (Unlisted, UK ; Manchester U.) ; Van Herk, Marcel (Unlisted, UK ; Manchester U.) ; Farabolini, Wilfrid (CERN) ; Zeeshan, Sumaira (CERN) ; Jones, Roger M (Manchester U. ; Cockcroft Inst. Accel. Sci. Tech.)
• First experimental demonstration of the relative insensitivity of VHEE beams to inhomogeneities. • Topas/GEANT4 simulations on experiments conducted at CERN’s CLEAR facility are in good agreement. [...]
2020 - 12 p. - Published in : Nucl. Instrum. Methods Phys. Res., B 482 (2020) 70-81
4.
Methods for VHEE/FLASH Radiotherapy Studies and High Dose Rate Dosimetry at the CLEAR User Facility / Korysko, Pierre (U. Oxford (main) ; CERN) ; Bateman, Joseph (U. Oxford (main) ; CERN) ; Corsini, Roberto (CERN) ; Dyks, Luke (CERN) ; Farabolini, Wilfrid (CERN) ; Rieker, Vilde (CERN) ; Robertson, Cameron (U. Oxford (main) ; CERN)
The CERN Linear Electron Accelerator for Research (CLEAR), operating since 2017, is a user facility providing electron beams for a varied and large range of experiments. The accelerator can generate a 60-220 MeV electron beam and it was recently selected to study the feasibility of using Very High Energy Electrons (VHEE) at Ultra High Dose Rate (UHDR) for cancer radiotherapy. [...]
2022 - 4 p. - Published in : JACoW LINAC 2022 (2022) 758-761 Fulltext: PDF;
In : 31st Linear Accelerator Conference (LINAC22), Liverpool, UK, 28 Aug - 2 Sep 2022, pp.758-761
5.
Real-time Plastic Scintillation Dosimetry of Ultra-High Dose Rate Very High Energy Electrons (VHEE) at CERN CLEAR Facility / Giguère, Cloé (Laval U.) ; Hart, Alexander (Victoria U.) ; Bateman, Joseph (Oxford U.) ; Korysko, Pierre (Oxford U. ; CERN) ; Farabolini, Wilfrid (CERN) ; LeChasseur, Yoan (McGill U.) ; Bazalova-Carter, Magdalena (Victoria U.) ; Beaulieu, Luc (Laval U.)
Very High Energy Electrons (VHEE) that can theoretically treat deep-seated tumours and be delivered at ultra-high dose rates (UHDR) could be the solution to translate FLASH radiotherapy into the clinic. Standard dosimeters have limited application in those extreme conditions, but dose-rate independent and fast-response plastic scintillation detectors (PSDs) are a potential alternative to overcome this. [...]
2024 - 4 p. - Published in : J. Phys. : Conf. Ser. 2799 (2024) 012016 Fulltext: PDF;
In : 13th International Conference on 3D dosimetry (IC3DDose 2024), Aarhus, Denmark, 17 - 19 Jun 2024, pp.012016
6.
Beam Optics Study for a Potential VHEE Beam Delivery System / Robertson, Cameron (JAI, UK) ; Burrows, Philip (JAI, UK) ; Dosanjh, Manjit (CERN) ; Gerbershagen, Alexander (CERN) ; Latina, Andrea (CERN)
VHEE (Very High Energy Electron) therapy can be superior to conventional radiotherapy for the treatment of deep seated tumours, whilst not necessarily requiring the space and cost of proton or heavy ion facilities. Developments in high gradient RF technology have allowed electrons to be accelerated to VHEE energies in a compact space, meaning that treatment could be possible with a shorter linac. [...]
2022 - 4 p. - Published in : JACoW IPAC 2022 (2022) 2992-2995 Fulltext: PDF;
In : 13th International Particle Accelerator Conference (IPAC 2022), Bangkok, Thailand, 12 - 17 Jun 2022, pp.2992-2995
7.
VHEE High Dose Rate Dosimetry Studies in CLEAR / Rieker, Vilde (CERN) ; Bateman, Joseph (JAI, UK ; CERN) ; Corsini, Roberto (CERN) ; Dyks, Luke (CERN ; Oxford U.) ; Farabolini, Wilfrid (IRFU, Saclay) ; Korysko, Pierre (Oxford U. ; CERN)
The 200 MeV electron beam of the CERN Linear Accelerator for Research (CLEAR) user facility at CERN has been intensively used to study the potential use of Very High Energy Electrons (VHEE) in cancer radiotherapy. In particular, irradiation tests have been performed in the high dose rate regime, which has gained a lot of interest for the so called FLASH biological effect, in which cancer cells are damaged while healthy tissue is largely spared. [...]
2022 - 4 p. - Published in : JACoW IPAC 2022 (2022) 3026-3029 Fulltext: PDF;
In : 13th International Particle Accelerator Conference (IPAC 2022), Bangkok, Thailand, 12 - 17 Jun 2022, pp.3026-3029
8.
Development of a novel fibre optic beam profile and dose monitor for very high energy electron radiotherapy at ultrahigh dose rates / Bateman, Joseph J (JAI, UK) ; Buchanan, Emma (CERN) ; Corsini, Roberto (CERN) ; Farabolini, Wilfrid (CERN) ; Korysko, Pierre (JAI, UK ; CERN) ; Larsen, Robert Garbrecht (CERN ; Groningen U.) ; Malyzhenkov, Alexander (CERN) ; Ruiz, Iñaki Ortega (CERN) ; Rieker, Vilde (CERN ; Oslo U.) ; Gerbershagen, Alexander (Groningen U.)
Objective. Very high energy electrons (VHEE) in the range of 50–250 MeV are of interest for treating deep-seated tumours with FLASH radiotherapy (RT). [...]
2024 - 16 p. - Published in : Phys. Med. Biol. 69 (2024) 085006 Fulltext: PDF;
9.
Mini-GRID radiotherapy on the CLEAR very-high-energy electron beamline: collimator optimization, film dosimetry, and Monte Carlo simulations / Clements, Nathan (Victoria U.) ; Esplen, Nolan (Victoria U.) ; Bateman, Joseph (Oxford U.) ; Robertson, Cameron (Oxford U.) ; Dosanjh, Manjit (Oxford U. ; CERN) ; Korysko, Pierre (Oxford U. ; CERN) ; Farabolini, Wilfrid (CERN) ; Corsini, Roberto (CERN) ; Bazalova-Carter, Magdalena (Victoria U.)
Objective. Spatially-fractionated radiotherapy (SFRT) delivered with a very-high-energy electron (VHEE) beam and a mini-GRID collimator was investigated to achieve synergistic normal tissue-sparing through spatial fractionation and the FLASH effect. [...]
2024 - 17 p. - Published in : Phys. Med. Biol. 69 (2024) 055003 Fulltext: PDF;
10.
Plastic Scintillator Dosimetry of Ultrahigh Dose-Rate 200 MeV Electrons at CLEAR / Hart, Alexander (Victoria U.) ; Giguère, Cloé (Laval U.) ; Bateman, Joseph (Oxford U.) ; Korysko, Pierre (Oxford U.) ; Farabolini, Wilfrid (CERN) ; Rieker, Vilde (CERN ; Oslo U.) ; Esplen, Nolan (Victoria U.) ; Corsini, Roberto (CERN) ; Dosanjh, Manjit (Oxford U.) ; Beaulieu, Luc (Laval U.) et al.
Very-high-energy electron (VHEE) beams with energies greater than 100 MeV may be promising candidates for FLASH radiotherapy due to their favorable dose distributions and accessibility of ultrahigh dose rates (UHDRs). Combining VHEE with the normal tissue-sparing FLASH effect of UHDR radiotherapy could improve patient outcomes. [...]
2024 - 9 p. - Published in : IEEE Sensors J. 24 (2024) 14229-14237

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