1.
|
Plastic Scintillator Dosimetry of Ultrahigh Dose-Rate 200 MeV Electrons at CLEAR
/ Hart, Alexander (Victoria U.) ; Giguère, Cloé (Laval U.) ; Bateman, Joseph (Oxford U.) ; Korysko, Pierre (Oxford U.) ; Farabolini, Wilfrid (CERN) ; Rieker, Vilde (CERN ; Oslo U.) ; Esplen, Nolan (Victoria U.) ; Corsini, Roberto (CERN) ; Dosanjh, Manjit (Oxford U.) ; Beaulieu, Luc (Laval U.) et al.
Very-high-energy electron (VHEE) beams with energies greater than 100 MeV may be promising candidates for FLASH radiotherapy due to their favorable dose distributions and accessibility of ultrahigh dose rates (UHDRs). Combining VHEE with the normal tissue-sparing FLASH effect of UHDR radiotherapy could improve patient outcomes. [...]
2024 - 9 p.
- Published in : IEEE Sensors J. 24 (2024) 14229-14237
|
|
2.
|
|
3.
|
Real-time Plastic Scintillation Dosimetry of Ultra-High Dose Rate Very High Energy Electrons (VHEE) at CERN CLEAR Facility
/ Giguère, Cloé (Laval U.) ; Hart, Alexander (Victoria U.) ; Bateman, Joseph (Oxford U.) ; Korysko, Pierre (Oxford U. ; CERN) ; Farabolini, Wilfrid (CERN) ; LeChasseur, Yoan (McGill U.) ; Bazalova-Carter, Magdalena (Victoria U.) ; Beaulieu, Luc (Laval U.)
Very High Energy Electrons (VHEE) that can theoretically treat deep-seated tumours and be delivered at ultra-high dose rates (UHDR) could be the solution to translate FLASH radiotherapy into the clinic. Standard dosimeters have limited application in those extreme conditions, but dose-rate independent and fast-response plastic scintillation detectors (PSDs) are a potential alternative to overcome this. [...]
2024 - 4 p.
- Published in : J. Phys. : Conf. Ser. 2799 (2024) 012016
Fulltext: PDF;
In : 13th International Conference on 3D dosimetry (IC3DDose 2024), Aarhus, Denmark, 17 - 19 Jun 2024, pp.012016
|
|
4.
|
Development of a novel fibre optic beam profile and dose monitor for very high energy electron radiotherapy at ultrahigh dose rates
/ Bateman, Joseph J (JAI, UK) ; Buchanan, Emma (CERN) ; Corsini, Roberto (CERN) ; Farabolini, Wilfrid (CERN) ; Korysko, Pierre (JAI, UK ; CERN) ; Larsen, Robert Garbrecht (CERN ; Groningen U.) ; Malyzhenkov, Alexander (CERN) ; Ruiz, Iñaki Ortega (CERN) ; Rieker, Vilde (CERN ; Oslo U.) ; Gerbershagen, Alexander (Groningen U.)
Objective. Very high energy electrons (VHEE) in the range of 50–250 MeV are of interest for treating deep-seated tumours with FLASH radiotherapy (RT). [...]
2024 - 16 p.
- Published in : Phys. Med. Biol. 69 (2024) 085006
Fulltext: PDF;
|
|
5.
|
A novel fibre optic monitor for VHEE UHDR beam monitoring: first tests at CLEAR
/ Bateman, Joseph (JAI, UK ; CERN) ; Buchanan, Emma (CERN) ; Corsini, Roberto (CERN) ; Gerbershagen, Alexander (Groningen U.) ; Ortega Ruiz, Inaki (CERN) ; Dosanjh, Manjit (JAI, UK ; CERN) ; Farabolini, Wilfrid (CERN) ; Rieker, Vilde (CERN ; Oslo U.) ; Korysko, Pierre (JAI, UK ; CERN) ; Malyzhenkov, Alexander (CERN)
Beam monitoring for Ultra High Dose Rate (UHDR) radiation therapy using pulsed beams, i.e. Very High Energy Electrons (VHEE), is a major challenge. [...]
2023
- Published in : JACoW IPAC 2023 (2023) THPL041
Fulltext: PDF;
In : 14th International Particle Accelerator Conference (IPAC 2023), Venice, Italy, 7 - 12 May 2023, pp.THPL041
|
|
6.
|
Methods for VHEE/FLASH Radiotherapy Studies and High Dose Rate Dosimetry at the CLEAR User Facility
/ Korysko, Pierre (U. Oxford (main) ; CERN) ; Bateman, Joseph (U. Oxford (main) ; CERN) ; Corsini, Roberto (CERN) ; Dyks, Luke (CERN) ; Farabolini, Wilfrid (CERN) ; Rieker, Vilde (CERN) ; Robertson, Cameron (U. Oxford (main) ; CERN)
The CERN Linear Electron Accelerator for Research (CLEAR), operating since 2017, is a user facility providing electron beams for a varied and large range of experiments. The accelerator can generate a 60-220 MeV electron beam and it was recently selected to study the feasibility of using Very High Energy Electrons (VHEE) at Ultra High Dose Rate (UHDR) for cancer radiotherapy. [...]
2022 - 4 p.
- Published in : JACoW LINAC 2022 (2022) 758-761
Fulltext: PDF;
In : 31st Linear Accelerator Conference (LINAC22), Liverpool, UK, 28 Aug - 2 Sep 2022, pp.758-761
|
|
7.
|
VHEE FLASH sparing effect measured at CLEAR, CERN with DNA damage of pBR322 plasmid as a biological endpoint
/ Wanstall, Hannah C (Manchester U. ; Daresbury) ; Korysko, Pierre (Oxford U. ; CERN) ; Farabolini, Wilfred (CERN) ; Corsini, Roberto (CERN) ; Bateman, Joseph J (Oxford U., Theor. Phys.) ; Rieker, Vilde (CERN ; Oslo U.) ; Hemming, Abigail (U. Manchester (main)) ; Henthorn, Nicholas T (U. Manchester (main) ; Manchester U.) ; Merchant, Michael J (Manchester U.) ; Santina, Elham (Manchester U.) et al.
Ultra-high dose rate (UHDR) irradiation has been shown to have a sparing effect on healthy tissue, an effect known as ‘FLASH’. This effect has been studied across several radiation modalities, including photons, protons and clinical energy electrons, however, very little data is available for the effect of FLASH with Very High Energy Electrons (VHEE). [...]
2024 - 13 p.
- Published in : Sci. Rep. 14 (2024) 14803
Fulltext: PDF;
|
|
8.
|
Characterization of Radiophotoluminescence Dosimeters Under X-Ray Irradiation at High Doses
/ Ferrari, M (Lab. Hubert Curien, St. Etienne) ; Aguiar, Y Q (CERN) ; Hasan, A (Lab. Hubert Curien, St. Etienne) ; Alem, A K (Lab. Hubert Curien, St. Etienne) ; Alía, R García (CERN) ; Donzella, A (Brescia U.) ; Pagano, D (Brescia U.) ; Sostero, L (Brescia U.) ; Zenoni, A (Brescia U.) ; Girard, S (Lab. Hubert Curien, St. Etienne ; IUF, Paris)
A characterization of radiophotoluminescence (RPL) dosimeters at high doses of X-ray radiation for applications in high-radiation areas is presented. Commercial FD-7 silver-doped phosphate glasses (1.5$\times$ 8.5mm) in use at CERN for passive dosimetry are irradiated using commercial X-ray tubes. [...]
2024 - 8 p.
- Published in : IEEE Trans. Nucl. Sci.
Fulltext: PDF;
In : Conference on Radiation and its Effects on Components and Systems (RADECS 2023), Toulouse, France, 25 - 29 Sep 2023, pp.1821-1828
|
|
9.
|
Active dosimetry for VHEE FLASH radiotherapy using beam profile monitors and charge measurements
/ Rieker, Vilde F (CERN ; Oslo U.) ; Corsini, Roberto (CERN) ; Stapnes, Steinar (CERN) ; Adli, Erik (Oslo U.) ; Farabolini, Wilfrid (CERN) ; Grilj, Veljko (SUBATECH, Nantes) ; Sjobak, Kyrre N (Oslo U.) ; Wroe, Laurence M (CERN) ; Aksoy, Avni (CERN ; Ankara U.) ; Robertson, Cameron S (Oxford U.) et al.
The discovery of the FLASH effect has revealed a high potential for treating cancer more efficiently by sparing
healthy tissue. The surge in related medical research activities over the last couple of years has triggered a
demand for technology with the capability of generating and measuring ionizing radiation at ultra-high doserates (UHDR). [...]
2024 - 12 p.
- Published in : Nucl. Instrum. Methods Phys. Res., A 1069 (2024) 169845
Fulltext: PDF;
|
|
10.
|
CERN-based experiments and Monte-Carlo studies on focused dose delivery with very high energy electron (VHEE) beams for radiotherapy applications
/ Whitmore, L (Manchester U. ; Cockcroft Inst. Accel. Sci. Tech. ; Texas U., Houston) ; Mackay, R I (Manchester U.) ; van Herk, M (Manchester U.) ; Korysko, P (Oxford U. ; CERN) ; Farabolini, W (CERN) ; Malyzhenkov, A (CERN) ; Corsini, R (CERN) ; Jones, R M (Manchester U. ; Cockcroft Inst. Accel. Sci. Tech.)
Very High Energy Electron (VHEE) beams are a promising alternative to conventional radiotherapy due to their highly penetrating nature and their applicability as a modality for FLASH (ultra-high dose-rate) radiotherapy. The dose distributions due to VHEE need to be optimised; one option is through the use of quadrupole magnets to focus the beam, reducing the dose to healthy tissue and allowing for targeted dose delivery at conventional or FLASH dose-rates. [...]
2024 - 15 p.
- Published in : Sci. Rep. 14 (2024) 11120
Fulltext: PDF;
|
|