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MARS pre-clinical imaging: the benefits of small pixels and good energy data
/ Butler, Philip H (MARS Bioimaging ; Canterbury U. ; Otago U.) ; Adebileje, Sikiru A (Otago U. ; Canterbury U.) ; Alexander, Steven D (MARS Bioimaging) ; Amma, Maya R (Otago U.) ; Amjomrouz, Marzieh (MARS Bioimaging) ; Asghariomabad, Fatemeh (Otago U.) ; Atharifard, Ali (MARS Bioimaging) ; Atlas, James (Canterbury U.) ; Bamford, Benjamin (Otago U.) ; Bell, Stephen T (MARS Bioimaging) et al.
Images from MARS spectral CT scanners show that there is much diagnostic value from using small pixels and good energy data. MARS scanners use energy-resolving photon-counting CZT Medipix3RX detectors that measure the energy of photons on a five-point scale and with a spatial resolution of 110 microns. [...]
2019
- Published in : Proc. SPIE 11113 (2019) 111130C
In : Developments in X-Ray Tomography XII, San Diego, CA, United States, 11 - 15 Aug 2019, pp.111130C
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Spectroscopic (multi-energy) CT distinguishes iodine and barium contrast material in MICE
/ Anderson, NG (Otago U., Dept Radiol, Christchurch) ; Butler, A P (Otago U., Dept Radiol, Christchurch) ; Firsching, M (Erlangen - Nuremberg U.) ; de Ruiter, N (Canterbury U.) ; Schleich, N (Christchurch Hosp, Christchurch) ; Butzer, J S (Karlsruhe, Inst. Technol.) ; Cook, N J (Christchurch Hosp, Christchurch) ; Grasset, R (Canterbury U.) ; Campbell, M (CERN) ; Scott, N J A (Otago U., Dept Med, Christchurch) et al.
Spectral CT differs from dual-energy CT by using a conventional X-ray tube and a photon-counting detector. We wished to produce 3D spectroscopic images of mice that distinguished calcium, iodine and barium. [...]
2010
- Published in : Eur. Radiol. 20 (2010) 2126-2134
In : European Congress of Radiology, Vienna, Austria, Mar 2006, pp.2126-2134
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Element-specific spectral imaging of multiple contrast agents: a phantom study
/ Panta, R K (U. Otago, Dept. Radiol. ; MARS Bioimaging) ; Bell, S T (MARS Bioimaging) ; Healy, J L (Canterbury U.) ; Aamir, R (U. Otago, Dept. Radiol. ; MARS Bioimaging) ; Bateman, C J (Lincoln University) ; Moghiseh, M (U. Otago, Dept. Radiol.) ; Butler, A P H (CERN ; U. Otago, Dept. Radiol. ; MARS Bioimaging ; Canterbury U.) ; Anderson, N G (U. Otago, Dept. Radiol.)
This work demonstrates the feasibility of simultaneous discrimination of multiple contrast agents based on their element-specific and energy-dependent X-ray attenuation properties using a pre-clinical photon-counting spectral CT. We used a photon-counting based pre-clinical spectral CT scanner with four energy thresholds to measure the X-ray attenuation properties of various concentrations of iodine (9, 18 and 36 mg/ml), gadolinium (2, 4 and 8 mg/ml) and gold (2, 4 and 8 mg/ml) based contrast agents, calcium chloride (140 and 280 mg/ml) and water. [...]
2018 - 17 p.
- Published in : JINST 13 (2018) T02001-T02001
Fulltext: PDF;
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MARS spectral molecular imaging of lamb tissue: data collection and image analysis
/ Aamir, R. (Otago U.) ; Chernoglazov, A. (Canterbury U.) ; Bateman, C.J. (Otago U.) ; Butler, A.P.H. (Otago U. ; CERN ; Canterbury U.) ; Butler, P.H. (CERN ; Canterbury U.) ; Anderson, N.G. (Otago U.) ; Bell, S.T. (Unlisted, NZ) ; Panta, R.K. (Otago U.) ; Healy, J.L. (Canterbury U.) ; Mohr, J.L. (Otago U.) et al.
Spectral molecular imaging is a new imaging technique able to discriminate and quantify different components of tissue simultaneously at high spatial and high energy resolution. Our MARS scanner is an x-ray based small animal CT system designed to be used in the diagnostic energy range (20 to 140 keV). [...]
arXiv:1311.4528.-
2014-02-17 - 11 p.
- Published in : JINST 9 (2014) P02005
Fulltext: PDF; IOP Open Access article: PDF; External link: Preprint
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Assessment of metal implant induced artefacts using photon counting spectral CT
/ Amma, Maya Rajeswari (Otago U.) ; Butler, Anthony P H (MARS Bioimaging ; Canterbury U. ; Otago U.) ; Raja, Aamir Y (Otago U.) ; Bamford, Benjamin (Otago U.) ; Butler, Philip (MARS Bioimaging ; Canterbury U. ; Otago U.) ; Walker, E Peter (Otago U.) ; Matanaghi, Aysouda (Otago U.) ; Adebileje, Sikiru A (Otago U. ; Canterbury U.) ; Anderson, Nigel (Otago U.) ; Anjomrouz, Marzieh (MARS Bioimaging) et al.
The aim is to perform qualitative and quantitative assessment of metal induced artefacts of small titanium biomaterials using photon counting spectral CT. The energy binning feature of some photon counting detectors enables the measured spectrum to be segmented into low, mid and high energy bins in a single exposure. [...]
2019 - 8 p.
- Published in : Proc. SPIE 11113 (2019) 111131D
In : Developments in X-Ray Tomography XII, San Diego, CA, United States, 11 - 15 Aug 2019, pp.111131D
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Quantitative imaging of excised osteoarthritic cartilage using spectral CT
/ Rajendran, Kishore (Otago U.) ; Löbker, Caroline (Otago U.) ; Schon, Benjamin S (Twente U., Enschede) ; Bateman, Christopher J (Otago U.) ; Younis, Raja Aamir (Otago U.) ; de Ruiter, Niels J A (Otago U.) ; Chernoglazov, Alex I (Canterbury U.) ; Ramyar, Mohsen (Otago U.) ; Hooper, Gary J (Otago U.) ; Butler, Anthony P H (Otago U. ; CERN ; MARS Bioimaging, New Zealand) et al.
Objectives:
To quantify iodine uptake in articular cartilage as a marker of glycosaminoglycan (GAG) content using multi-energy spectral CT.
Methods:
We incubated a 25-mm strip of excised osteoarthritic human tibial plateau in 50 % ionic iodine contrast and imaged it using a small-animal spectral scanner with a cadmium telluride photon-processing detector to quantify the iodine through the thickness of the articular cartilage. We imaged both spectroscopic phantoms and osteoarthritic tibial plateau samples. [...]
2017 - 9 p.
- Published in : Eur. Radiol. 27 (2017) 384-392
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Multi‐“Color” Delineation of Bone Microdamages Using Ligand‐Directed Sub‐5 nm Hafnia Nanodots and Photon Counting CT Imaging
/ Ostadhossein, Fatemeh (Illinois U., Urbana) ; Tripathi, Indu (Illinois U., Urbana) ; Benig, Lily (Illinois U., Urbana) ; LoBato, Denae (Illinois U., Urbana) ; Moghiseh, Mahdieh (Otago U.) ; Lowe, Chiara (Otago U.) ; Raja, Aamir (Otago U.) ; Butler, Anthony (Otago U. ; CERN) ; Panta, Raj (Otago U.) ; Anjomrouz, Marzieh (Otago U.) et al.
The early detection of bone microdamages is crucial to make informed deci-sions about the therapy and taking precautionary treatments to avoid cata-strophic fractures. Conventional computed tomography (CT) imaging faces obstacles in detecting bone microdamages due to the strong self-attenuation of photons from bone and poor spatial resolution. [...]
2019
- Published in : Advanced Functional Materials 30 (2019) 1904936
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Multi-energy spectral photon-counting computed tomography (MARS) for detection of arthroplasty implant failure
/ Lau, Lawrence Chun Man (Hong Kong, Chinese U.) ; Lee, Wayne Yuk Wai (Hong Kong, Chinese U.) ; Butler, Anthony P H (Otago U. ; Canterbury U. ; CERN ; MARS Bioimaging) ; Chernoglazov, Alex I (MARS Bioimaging) ; Chung, Kwong Yin (Hong Kong, Chinese U.) ; Ho, Kevin Ki Wai (Hong Kong, Chinese U.) ; Grifth, James (Hong Kong, Chinese U.) ; Butler, Philip H (Canterbury U. ; CERN ; MARS Bioimaging) ; Yung, Patrick Shu Hang (Hong Kong, Chinese U.)
To determine whether state-of-the-art multi-energy spectral photon-counting computed tomography
(MARS) can detect knee arthroplasty implant failure not detected by standard pre-operative imaging
techniques. A total knee arthroplasty (TKA) removed from a patient was reviewed. [...]
2021 - 6 p.
- Published in : Sci. Rep. 11 (2021) 1554
Fulltext: PDF;
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