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Element-specific spectral imaging of multiple contrast agents: a phantom study
/ Panta, R K (U. Otago, Dept. Radiol. ; MARS Bioimaging) ; Bell, S T (MARS Bioimaging) ; Healy, J L (Canterbury U.) ; Aamir, R (U. Otago, Dept. Radiol. ; MARS Bioimaging) ; Bateman, C J (Lincoln University) ; Moghiseh, M (U. Otago, Dept. Radiol.) ; Butler, A P H (CERN ; U. Otago, Dept. Radiol. ; MARS Bioimaging ; Canterbury U.) ; Anderson, N G (U. Otago, Dept. Radiol.)
This work demonstrates the feasibility of simultaneous discrimination of multiple contrast agents based on their element-specific and energy-dependent X-ray attenuation properties using a pre-clinical photon-counting spectral CT. We used a photon-counting based pre-clinical spectral CT scanner with four energy thresholds to measure the X-ray attenuation properties of various concentrations of iodine (9, 18 and 36 mg/ml), gadolinium (2, 4 and 8 mg/ml) and gold (2, 4 and 8 mg/ml) based contrast agents, calcium chloride (140 and 280 mg/ml) and water. [...]
2018 - 17 p.
- Published in : JINST 13 (2018) T02001-T02001
Fulltext: PDF;
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3.
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MARS-MD: rejection based image domain material decomposition
/ Bateman, C.J. (MARS Bioimaging ; U. Otago, Dept. Radiol. ; Canterbury U. ; Lincoln Agritech Limited, New Zealand) ; Knight, D. (U. Otago, Dept. Radiol.) ; Brandwacht, B. (Twente U., Enschede) ; Mahon, J., MC (Canterbury U.) ; Healy, J. (U. Canterbury, Dept. Biol.) ; Panta, R. (U. Otago, Dept. Radiol. ; MARS Bioimaging) ; Aamir, R. (U. Otago, Dept. Radiol.) ; Rajendran, K. (U. Otago, Dept. Radiol.) ; Moghiseh, M. (U. Otago, Dept. Radiol.) ; Ramyar, M. (U. Otago, Dept. Radiol.) et al.
This paper outlines image domain material decomposition algorithms that have been routinely used in MARS spectral CT systems. These algorithms (known collectively as MARS-MD) are based on a pragmatic heuristic for solving the under-determined problem where there are more materials than energy bins. [...]
arXiv:1802.05366.-
2018-03-16
- Published in : JINST 13 (2018) P05020-P05020
Preprint: arXiv:1802.05366 - PDF; 10.1088.1748-0221.13.05.P05020 - PDF;
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4.
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Quantitative imaging of excised osteoarthritic cartilage using spectral CT
/ Rajendran, Kishore (Otago U.) ; Löbker, Caroline (Otago U.) ; Schon, Benjamin S (Twente U., Enschede) ; Bateman, Christopher J (Otago U.) ; Younis, Raja Aamir (Otago U.) ; de Ruiter, Niels J A (Otago U.) ; Chernoglazov, Alex I (Canterbury U.) ; Ramyar, Mohsen (Otago U.) ; Hooper, Gary J (Otago U.) ; Butler, Anthony P H (Otago U. ; CERN ; MARS Bioimaging, New Zealand) et al.
Objectives:
To quantify iodine uptake in articular cartilage as a marker of glycosaminoglycan (GAG) content using multi-energy spectral CT.
Methods:
We incubated a 25-mm strip of excised osteoarthritic human tibial plateau in 50 % ionic iodine contrast and imaged it using a small-animal spectral scanner with a cadmium telluride photon-processing detector to quantify the iodine through the thickness of the articular cartilage. We imaged both spectroscopic phantoms and osteoarthritic tibial plateau samples. [...]
2017 - 9 p.
- Published in : Eur. Radiol. 27 (2017) 384-392
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5.
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Energy Calibration of the Pixels of Spectral X-ray Detectors
/ Panta, Raj Kumar (Otago U.) ; Walsh, Michael F (MARS Bioimaging Ltd., Christchurch) ; Bell, Stephen T (MARS Bioimaging Ltd., Christchurch) ; Anderson, Nigel G (Otago U.) ; Butler, Anthony P (Otago U. ; Canterbury U. ; CERN ; MARS Bioimaging Ltd., Christchurch) ; Butler, Philip H (Canterbury U. ; CERN ; MARS Bioimaging Ltd., Christchurch)
The energy information acquired using spectral X-ray detectors allows noninvasive identification and characterization of chemical components of a material. To achieve this, it is important that the energy response of the detector is calibrated. [...]
2015 - 10 p.
- Published in : IEEE Trans. Med. Imaging 34 (2015) 697-706
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6.
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7.
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Reducing beam hardening effects and metal artefacts using Medipix3RX: With applications from biomaterial science
/ Rajendran, K. ; Walsh, M.F. ; de Ruiter, N.J.A. ; Chernoglazov, A.I. ; Panta, R.K. ; Butler, A.P.H. ; Butler, P.H. ; Bell, S.T. ; Anderson, N.G. ; Woodfield, T.B.F. et al.
This paper discusses methods for reducing beam hardening effects using spectral data for biomaterial applications. A small-animal spectral scanner operating in the diagnostic energy range was used. [...]
arXiv:1311.5303.-
2014-03-26 - 11 p.
- Published in : JINST 9 (2014) P03015
Preprint: PDF; External link: Preprint
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8.
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MARS spectral molecular imaging of lamb tissue: data collection and image analysis
/ Aamir, R. (Otago U.) ; Chernoglazov, A. (Canterbury U.) ; Bateman, C.J. (Otago U.) ; Butler, A.P.H. (Otago U. ; CERN ; Canterbury U.) ; Butler, P.H. (CERN ; Canterbury U.) ; Anderson, N.G. (Otago U.) ; Bell, S.T. (Unlisted, NZ) ; Panta, R.K. (Otago U.) ; Healy, J.L. (Canterbury U.) ; Mohr, J.L. (Otago U.) et al.
Spectral molecular imaging is a new imaging technique able to discriminate and quantify different components of tissue simultaneously at high spatial and high energy resolution. Our MARS scanner is an x-ray based small animal CT system designed to be used in the diagnostic energy range (20 to 140 keV). [...]
arXiv:1311.4528.-
2014-02-17 - 11 p.
- Published in : JINST 9 (2014) P02005
Fulltext: PDF; IOP Open Access article: PDF; External link: Preprint
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9.
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Processing of spectral X-ray data with principal components analysis
/ Butler, A P H (CERN ; Otago U. ; Canterbury U.) ; Butler, P H (CERN ; Canterbury U.) ; Cook, N J (Canterbury U. ; Otago U.) ; Butzer, J (Karlsruhe U. ; Canterbury U.) ; Schleich, N (Canterbury U.) ; Tlustos, L (CERN) ; Scott, N (Otago U.) ; Grasset, R (Canterbury U.) ; de Ruiter, N (Canterbury U.) ; Anderson, N G (Otago U.)
The goal of the work was to develop a general method for processing spectral x-ray image data. Principle component analysis (PCA) is a well understood technique for multivariate data analysis and so was investigated. [...]
2011
- Published in : Nucl. Instrum. Methods Phys. Res., A 633 (2011) S140-S142
In : 11th International Workshop On Radiation Imaging Detectors, Prague, Czech Republic, 28 Jun - 02 Jul 2009, pp.S140-S142
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10.
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Spectroscopic (multi-energy) CT distinguishes iodine and barium contrast material in MICE
/ Anderson, NG (Otago U., Dept Radiol, Christchurch) ; Butler, A P (Otago U., Dept Radiol, Christchurch) ; Firsching, M (Erlangen - Nuremberg U.) ; de Ruiter, N (Canterbury U.) ; Schleich, N (Christchurch Hosp, Christchurch) ; Butzer, J S (Karlsruhe, Inst. Technol.) ; Cook, N J (Christchurch Hosp, Christchurch) ; Grasset, R (Canterbury U.) ; Campbell, M (CERN) ; Scott, N J A (Otago U., Dept Med, Christchurch) et al.
Spectral CT differs from dual-energy CT by using a conventional X-ray tube and a photon-counting detector. We wished to produce 3D spectroscopic images of mice that distinguished calcium, iodine and barium. [...]
2010
- Published in : Eur. Radiol. 20 (2010) 2126-2134
In : European Congress of Radiology, Vienna, Austria, Mar 2006, pp.2126-2134
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