000748315 001__ 748315
000748315 003__ SzGeCERN
000748315 005__ 20121219060443.0
000748315 0248_ $$aoai:cds.cern.ch:748315$$pcerncds:FULLTEXT
000748315 035__ $$9INIS$$a34002126
000748315 041__ $$ajpn
000748315 088__ $$aJAERI-RESEARCH-2002-011
000748315 100__ $$aYamamoto, T
000748315 245__ $$aIn vitro biological effectiveness of JRR-4 epithermal neutron beam. Experiment under free air beam and in water phantom. Cooperative research
000748315 260__ $$c2002
000748315 300__ $$a66 p
000748315 520__ $$aThe surviving curve and the biological effectiveness factor of dose components generated in boron neutron capture therapy (BNCT) were separately determined in neutron beams at Japan Research Reactor No.4. Surviving fraction of V79 Chinese hamster cell with or without sup 1 sup 0 B was obtained using an epithermal neutron beam (ENB), a mixed thermal-epithermal neutron beam (TNB-1), and a thermal neutron beam (TNB-2), which were used or planned to use for BNCT clinical trial. The cell killing effect of these neutron beams with or without the presence of sup 1 sup 0 B depended highly on the neutron beam used, according to the epithermal and fast neutron content in the beam. The biological effectiveness factor values of the boron capture reaction for ENB, TNB-1 and TNB-2 were 3.99+-0.24, 3.04+-0.19 and 1.43+-0.08, respectively. The biological effectiveness factor values of the high-LET dose components based on the hydrogen recoils and the nitrogen capture reaction were 2.50+-0.32, 2.34+-0.30 and 2.17+-0.28 for ENB, TNB-1 and TNB-2, respectively. The biological effectiveness factor values of the neutron and photon components were 1.22+-0.16, 1.23+-0.16 and 1.21+-0.16, respectively. The depth function of biological effectiveness factor in water phantom and the difference in biological effectiveness factor among boron compounds were also determined. The experimental determination of biological effectiveness factor outlined in this paper is applicable to the dose calculation for each dose component of the neutron beams and contribute to an accurate biological effectiveness factor as comparison with a neutron beam at a different facility employed in ongoing and planned BNCT clinical trials.
000748315 595__ $$aSIS INIS2004
000748315 65017 $$2SzGeCERN$$aHealth Physics and Radiation Effects
000748315 690C_ $$aREPORT
000748315 694__ $$9INIS$$aRadiology and nuclear medecine
000748315 695__ $$9INIS$$abaryons-
000748315 695__ $$9INIS$$abeams-
000748315 695__ $$9INIS$$abiological-effects
000748315 695__ $$9INIS$$aboron-10
000748315 695__ $$9INIS$$aboron-isotopes
000748315 695__ $$9INIS$$acell-killing
000748315 695__ $$9INIS$$acolony-formation
000748315 695__ $$9INIS$$adose-equivalents
000748315 695__ $$9INIS$$adoses-
000748315 695__ $$9INIS$$adosimetry-
000748315 695__ $$9INIS$$aelementary-particles
000748315 695__ $$9INIS$$aenriched-uranium-reactors
000748315 695__ $$9INIS$$aepithermal-neutrons
000748315 695__ $$9INIS$$aevaluation-
000748315 695__ $$9INIS$$afermions-
000748315 695__ $$9INIS$$agamma-dosimetry
000748315 695__ $$9INIS$$ahadrons-
000748315 695__ $$9INIS$$ain-vitro
000748315 695__ $$9INIS$$aisotopes-
000748315 695__ $$9INIS$$ajrr-4-reactor
000748315 695__ $$9INIS$$alight-nuclei
000748315 695__ $$9INIS$$amedicine-
000748315 695__ $$9INIS$$amockup-
000748315 695__ $$9INIS$$aneutron-beams
000748315 695__ $$9INIS$$aneutron-capture-therapy
000748315 695__ $$9INIS$$aneutrons-
000748315 695__ $$9INIS$$aneutron-therapy
000748315 695__ $$9INIS$$anuclear-medicine
000748315 695__ $$9INIS$$anuclei-
000748315 695__ $$9INIS$$anucleon-beams
000748315 695__ $$9INIS$$anucleons-
000748315 695__ $$9INIS$$aodd-odd-nuclei
000748315 695__ $$9INIS$$aparticle-beams
000748315 695__ $$9INIS$$aphantoms-
000748315 695__ $$9INIS$$apool-type-reactors
000748315 695__ $$9INIS$$aradiation-doses
000748315 695__ $$9INIS$$aradiology-
000748315 695__ $$9INIS$$aradiotherapy-
000748315 695__ $$9INIS$$arbe-
000748315 695__ $$9INIS$$areactors-
000748315 695__ $$9INIS$$aresearch-and-test-reactors
000748315 695__ $$9INIS$$aresearch-reactors
000748315 695__ $$9INIS$$aspace-dependence
000748315 695__ $$9INIS$$astable-isotopes
000748315 695__ $$9INIS$$astructural-models
000748315 695__ $$9INIS$$asurvival-curves
000748315 695__ $$9INIS$$atherapy-
000748315 695__ $$9INIS$$awater-cooled-reactors
000748315 695__ $$9INIS$$awater-moderated-reactors
000748315 700__ $$aHori, N
000748315 700__ $$aHoriguchi, Y
000748315 700__ $$aKishi, T
000748315 700__ $$aKumada, H
000748315 700__ $$aMatsumura, A
000748315 700__ $$aNose, T
000748315 700__ $$aTorii, Y
000748315 700__ $$aYamamoto, K
000748315 8564_ $$uhttp://doc.cern.ch/archive/electronic/other/uploader/INIS/34002126.pdf$$yfulltext
000748315 8564_ $$uhttps://cds.cern.ch/record/748315/files/34002126.pdf$$yfulltext
000748315 916__ $$sn$$w200426
000748315 960__ $$a21
000748315 961__ $$c20080605$$h2022$$lCER01$$x20040629
000748315 963__ $$aPUBLIC
000748315 970__ $$a002459680CER
000748315 980__ $$aBOOK
000748315 980__ $$bREPORT