| Article | |
| Title | Production of Mass-Separated Erbium-169 Towards the First Preclinical in vitro Investigations |
| Author(s) | Talip, Zeynep (PSI, Villigen) ; Borgna, Francesca (PSI, Villigen) ; Müller, Cristina (PSI, Villigen ; ETH, Zurich (main)) ; Ulrich, Jiri (PSI, Villigen) ; Duchemin, Charlotte (CERN ; Leuven U.) ; Ramos, Joao P (CERN ; Leuven U.) ; Stora, Thierry (CERN) ; Köster, Ulli (Laue-Langevin Inst.) ; Nedjadi, Youcef (Lausanne U.) ; Gadelshin, Vadim (CERN ; Mainz U., Inst. Phys. ; Urals State U.) ; Fedosseev, Valentin N (CERN) ; Juget, Frederic (Lausanne U.) ; Bailat, Claude (Lausanne U.) ; Fankhauser, Adelheid (PSI, Villigen) ; Wilkins, Shane G (CERN) ; Lambert, Laura (CERN) ; Marsh, Bruce (CERN) ; Fedorov, Dmitry (St. Petersburg, INP) ; Chevallay, Eric (CERN) ; Fernier, Pascal (CERN) ; Schibli, Roger (PSI, Villigen ; ETH, Zurich (main)) ; van der Meulen, Nicholas P (PSI, Villigen) |
| Publication | 2021 |
| Number of pages | 11 |
| In: | Frontiers in Medicine 8 (2021) 643175 |
| DOI | 10.3389/fmed.2021.643175 |
| Subject category | Health Physics and Radiation Effects |
| Abstract | The $\beta^-$-particle-emitting erbium-169 is a potential radionuclide toward therapy of metastasized cancer diseases. It can be produced in nuclear research reactors, irradiating isotopically-enriched $^{168}$Er$_2$O$_3$. This path, however, is not suitable for receptor-targeted radionuclide therapy, where high specific molar activities are required. In this study, an electromagnetic isotope separation technique was applied after neutron irradiation to boost the specific activity by separating $^{169}$Er from $^{168}$Er targets. The separation efficiency increased up to 0.5% using resonant laser ionization. A subsequent chemical purification process was developed as well as activity standardization of the radionuclidically pure $^{169}$Er. The quality of the $^{169}$Er product permitted radiolabeling and pre-clinical studies. A preliminary in vitro experiment was accomplished, using a $^{169}$Er-PSMA-617, to show the potential of $^{169}$Er to reduce tumor cell viability |
| Copyright/License | © 2021-2025 Talip, Borgna, Müller, Ulrich, Duchemin, Ramos, Stora, Köster, Nedjadi, Gadelshin, Fedosseev, Juget, Bailat, Fankhauser, Wilkins, Lambert, Marsh, Fedorov, Chevallay, Fernier, Schibli and van der Meulen (License: CC-BY-4.0) |
Corresponding record in: Inspire
レコード 生成： 2022-03-12, 最終変更： 2022-03-14
