002704703 001__ 2704703
002704703 003__ SzGeCERN
002704703 005__ 20191220170058.0
002704703 0247_ $$2DOI$$9International Society for Optics and Photonics$$a10.1117/12.2532367
002704703 0248_ $$aoai:inspirehep.net:1769160$$pcerncds:CERN$$qForCDS
002704703 035__ $$9http://inspirehep.net/oai2d$$aoai:inspirehep.net:1769160$$d2019-12-17T16:03:13Z$$h2019-12-18T07:01:27Z$$mmarcxml
002704703 035__ $$9Inspire$$a1769160
002704703 041__ $$aeng
002704703 100__ $$aButler, Philip H$$uMARS Bioimaging$$uCanterbury U.$$uOtago U.$$vUniv. of Canterbury (New Zealand)
002704703 245__ $$9International Society for Optics and Photonics$$aMARS pre-clinical imaging: the benefits of small pixels and good energy data
002704703 260__ $$c2019
002704703 520__ $$9International Society for Optics and Photonics$$aImages from MARS spectral CT scanners show that there is much diagnostic value from using small pixels and good energy data. MARS scanners use energy-resolving photon-counting CZT Medipix3RX detectors that measure the energy of photons on a five-point scale and with a spatial resolution of 110 microns. The energy information gives good material discrimination and quantification. The 3D reconstruction gives a voxel size of 70 microns. We present images of pre-clinical specimens, including excised atheroma, bone and joint samples, and nanoparticle contrast agents along with images from living humans. Images of excised human plaque tissue show the location and extent of lipid and calcium deposition within the artery wall. The presence of intraplaque haemorrhage, where the blood leaks into the artery wall following a rupture, has also been visualised through the detection of iron. Several clinically important bone and joint problems have been investigated including: site-specific bone mineral density, bone-metal interfaces (spectral CT reduces metal artefacts), cartilage health using ionic contrast media, gout and pseudogout crystals, and microfracture assessment using nanoparticles. Metallic nanoparticles have been investigated as a cellular marker visible in MARS images. Cell lines of different cancer types (Raji and SK-BR3) were incubated with monoclonal antibody-functionalised AuNPs (Herceptin and Rituximab). We identified and quantified the labelled AuNPs demonstrating that Herceptin-functionalised AuNPs bound to SK-BR3 breast cancer cells but not to the Raji lymphoma cells. In vivo human images show the bone microstructure. Fat, water, and calcium concentrations are quantifiable.
002704703 65017 $$2SzGeCERN$$aParticle Physics - Experiment
002704703 6531_ $$9author$$aspectral CT
002704703 6531_ $$9author$$amultiple material discrimination
002704703 6531_ $$9author$$aMedipix
002704703 6531_ $$9author$$aenergy-resolving photon-counting
002704703 6531_ $$9author$$apre-clinical imaging
002704703 6531_ $$9author$$asoft tissue imaging
002704703 6531_ $$9author$$abone and joint imaging
002704703 6531_ $$9author$$ananoparticle imaging
002704703 690C_ $$aCERN
002704703 700__ $$aAdebileje, Sikiru A$$uOtago U.$$uCanterbury U.$$vUniv. of Canterbury (New Zealand)
002704703 700__ $$aAlexander, Steven D$$uMARS Bioimaging
002704703 700__ $$aAmma, Maya R$$uOtago U.
002704703 700__ $$aAmjomrouz, Marzieh$$uMARS Bioimaging
002704703 700__ $$aAsghariomabad, Fatemeh$$uOtago U.
002704703 700__ $$aAtharifard, Ali$$uMARS Bioimaging
002704703 700__ $$aAtlas, James$$uCanterbury U.
002704703 700__ $$aBamford, Benjamin$$uOtago U.
002704703 700__ $$aBell, Stephen T$$uMARS Bioimaging
002704703 700__ $$aBheesette, Srinidhi$$uMARS Bioimaging$$uOtago U.$$uCERN$$vUniv. of Otago, Christchurch (New Zealand)
002704703 700__ $$aButler, Anthony P H$$uMARS Bioimaging$$uCanterbury U.$$uOtago U.$$vUniv. of Canterbury (New Zealand)
002704703 700__ $$aCarbonez, Pierre$$uOtago U.$$uCERN$$vEuropean Organisation for Nuclear Research (Switzerland)
002704703 700__ $$aChambers, Claire$$uCanterbury U.
002704703 700__ $$aChernoglazov, Alexander I$$uMARS Bioimaging$$uCanterbury U.$$vUniv. of Canterbury (New Zealand)
002704703 700__ $$aClark, Jennifer A$$uOtago U.$$vAra Institute of Canterbury (New Zealand)
002704703 700__ $$aCrighton, Jonathan S$$uOtago U.
002704703 700__ $$aDahal, Shishir$$uOtago U.$$uUnlisted, NP$$vMinistry of Health (Nepal)
002704703 700__ $$aDamet, Jérôme$$uOtago U.$$uCERN$$vEuropean Organisation for Nuclear Research (Switzerland)
002704703 700__ $$ade Ruiter, Neils J A$$uMARS Bioimaging$$uCanterbury U.$$uOtago U.$$vUniv. of Canterbury (New Zealand)
002704703 700__ $$aDoesburg, Robert M N$$uMARS Bioimaging
002704703 700__ $$aDuncan, Neryda$$uCanterbury U.
002704703 700__ $$aGhodsian, Nooshin$$uCanterbury U.
002704703 700__ $$aGieseg, Steven P$$uOtago U.$$uCanterbury U.$$uCERN$$vUniv. of Otago, Christchurch (New Zealand)
002704703 700__ $$aGoulter, Brian P$$uMARS Bioimaging
002704703 700__ $$aGurney, Sam$$uOtago U.
002704703 700__ $$aHealy, Joseph L$$uMARS Bioimaging
002704703 700__ $$aKanithi, Praveenkumar$$uCanterbury U.
002704703 700__ $$aKirkbride, Tracy
002704703 700__ $$aLansley, Stuart P$$uMARS Bioimaging$$uCERN$$vEuropean Organisation for Nuclear Research (Switzerland)
002704703 700__ $$aLowe, Chiara$$uOtago U.
002704703 700__ $$aMandalika, V B H$$uMARS Bioimaging$$uCanterbury U.$$vUniv. of Canterbury (New Zealand)
002704703 700__ $$aMarfo, Emmanuel$$uOtago U.
002704703 700__ $$aMatanaghi, Aysouda$$uOtago U.
002704703 700__ $$aMoghiseh, Mahdieh$$uMARS Bioimaging$$uOtago U.$$vUniv. of Otago, Christchurch (New Zealand)
002704703 700__ $$aPalmer, David$$uLincoln U.
002704703 700__ $$aPanta, Raj K$$uMARS Bioimaging$$uOtago U.$$uCERN$$vUniv. of Otago, Christchurch (New Zealand)
002704703 700__ $$aPrebble, Hannah M$$uMARS Bioimaging
002704703 700__ $$aRaja, Aamir Y$$uMARS Bioimaging$$uOtago U.$$vUniv. of Otago, Christchurch (New Zealand)
002704703 700__ $$aSayous, Yann$$uCanterbury U.
002704703 700__ $$aRenaud, Peter$$uCanterbury U.$$uOtago U.$$vUniv. of Otago, Christchurch (New Zealand)
002704703 700__ $$aSchleich, Nanette$$uOtago U.
002704703 700__ $$aSearle, Emily$$uCanterbury U.
002704703 700__ $$aSheeja, Jereena S$$uOtago U.
002704703 700__ $$aUddin, Rayhan$$uCanterbury U.
002704703 700__ $$aBroeke, Lieza Vanden$$uMARS Bioimaging
002704703 700__ $$aVivek, V S$$uMARS Bioimaging
002704703 700__ $$aWalker, E Peter$$uOtago U.
002704703 700__ $$aWalsh, Michael F$$uMARS Bioimaging
002704703 700__ $$aWijesooriya, Manoj$$uCanterbury U.
002704703 700__ $$aYounger, W Ross$$uMARS Bioimaging
002704703 773__ $$c111130C$$pProc. SPIE$$v11113$$wC19-08-11$$y2019
002704703 960__ $$a13
002704703 962__ $$b2705427$$k111130C$$nsandiego20190811
002704703 980__ $$aARTICLE
002704703 980__ $$aConferencePaper