002655913 001__ 2655913
002655913 003__ SzGeCERN
002655913 005__ 20220810142848.0
002655913 0247_ $$2DOI$$9submitter$$a10.1088/1748-0221/13/02/T02001
002655913 0248_ $$aoai:inspirehep.net:1718433$$pcerncds:CERN:FULLTEXT$$pcerncds:FULLTEXT$$pcerncds:CERN$$qForCDS
002655913 035__ $$9http://inspirehep.net/oai2d$$aoai:inspirehep.net:1718433$$d2019-02-05T14:02:30Z$$h2019-02-06T06:22:47Z$$mmarcxml
002655913 035__ $$9Inspire$$a1718433
002655913 041__ $$aeng
002655913 100__ $$aPanta, R [email protected]$$uU. Otago, Dept. Radiol.$$uMARS Bioimaging
002655913 245__ $$9submitter$$aElement-specific spectral imaging of multiple contrast agents: a phantom study
002655913 246__ $$9crossref$$aElement-specific spectral imaging of multiple contrast agents: a phantom study
002655913 260__ $$c2018
002655913 300__ $$a17 p
002655913 520__ $$9submitter$$aThis work demonstrates the feasibility of simultaneous discrimination of multiple contrast agents based on their element-specific and energy-dependent X-ray attenuation properties using a pre-clinical photon-counting spectral CT. We used a photon-counting based pre-clinical spectral CT scanner with four energy thresholds to measure the X-ray attenuation properties of various concentrations of iodine (9, 18 and 36 mg/ml), gadolinium (2, 4 and 8 mg/ml) and gold (2, 4 and 8 mg/ml) based contrast agents, calcium chloride (140 and 280 mg/ml) and water. We evaluated the spectral imaging performances of different energy threshold schemes between 25 to 82 keV at 118 kVp, based on K-factor and signal-to-noise ratio and ranked them. K-factor was defined as the X-ray attenuation in the K-edge containing energy range divided by the X-ray attenuation in the preceding energy range, expressed as a percentage. We evaluated the effectiveness of the optimised energy selection to discriminate all three contrast agents in a phantom of 33 mm diameter. A photon-counting spectral CT using four energy thresholds of 27, 33, 49 and 81 keV at 118 kVp simultaneously discriminated three contrast agents based on iodine, gadolinium and gold at various concentrations using their K-edge and energy-dependent X-ray attenuation features in a single scan. A ranking method to evaluate spectral imaging performance enabled energy thresholds to be optimised to discriminate iodine, gadolinium and gold contrast agents in a single spectral CT scan. Simultaneous discrimination of multiple contrast agents in a single scan is likely to open up new possibilities of improving the accuracy of disease diagnosis by simultaneously imaging multiple bio-markers each labelled with a nano-contrast agent.
002655913 540__ $$3publication$$aCC-BY-3.0$$uhttps://creativecommons.org/licenses/by/3.0/
002655913 542__ $$3publication$$f© 2018 CERN
002655913 65017 $$2SzGeCERN$$aDetectors and Experimental Techniques
002655913 690C_ $$aCERN
002655913 690C_ $$aARTICLE
002655913 700__ $$aBell, S T$$uMARS Bioimaging
002655913 700__ $$aHealy, J L$$uCanterbury U.
002655913 700__ $$aAamir, R$$uU. Otago, Dept. Radiol.$$uMARS Bioimaging
002655913 700__ $$aBateman, C J$$uLincoln University
002655913 700__ $$aMoghiseh, M$$uU. Otago, Dept. Radiol.
002655913 700__ $$aButler, A P H$$uCERN$$uU. Otago, Dept. Radiol.$$uMARS Bioimaging$$uCanterbury U.
002655913 700__ $$aAnderson, N G$$uU. Otago, Dept. Radiol.
002655913 773__ $$cT02001-T02001$$n02$$pJINST$$v13$$y2018
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002655913 960__ $$a13
002655913 980__ $$aARTICLE