002046055 001__ 2046055
002046055 003__ SzGeCERN
002046055 005__ 20151107000230.0
002046055 0247_ $$2DOI$$a10.1016/j.radonc.2007.11.028
002046055 0248_ $$aoai:cds.cern.ch:2046055$$pcerncds:CERN
002046055 041__ $$aeng
002046055 100__ $$aBassler, Niels$$uAarhus U. Hospital$$uDeutsches Krebsforsch., Heidelberg
002046055 245__ $$aAntiproton radiotherapy
002046055 260__ $$c2008
002046055 300__ $$a5 p
002046055 520__ $$aAntiprotons are interesting as a possible future modality in radiation therapy for the following reasons: When fast antiprotons penetrate matter, protons and antiprotons have near identical stopping powers and exhibit equal radiobiology well before the Bragg-peak. But when the antiprotons come to rest at the Bragg-peak, they annihilate, releasing almost 2 GeV per antiproton–proton annihilation. Most of this energy is carried away by energetic pions, but the Bragg-peak of the antiprotons is still locally augmented with ∼20–30 MeV per antiproton. Apart from the gain in physical dose, an increased relative biological effect also has been observed, which can be explained by the fact that some of the secondary particles from the antiproton annihilation exhibit high-LET properties. Finally, the weakly interacting energetic pions, which are leaving the target volume, may provide a real time feedback on the exact location of the annihilation peak. We have performed dosimetry experiments and investigated the radiobiological properties using the antiproton beam available at CERN, Geneva. Dosimetry experiments were carried out with ionization chambers, alanine pellets and radiochromic film. Radiobiological experiments were done with V79 WNRE Chinese hamster cells. The radiobiological experiments were repeated with protons and carbon ions at TRIUMF and GSI, respectively, for comparison. Several Monte Carlo particle transport codes were investigated and compared with our experimental data obtained at CERN. The code that matched our data best was used to generate a set of depth dose data at several energies, including secondary particle-energy spectra. This can be used as base data for a treatment planning software such as TRiP. Our findings from the CERN experiments indicate that the biological effect of antiprotons in the plateau region may be reduced by a factor of 4 for the same biological target dose in a spread-out Bragg-peak, when comparing with protons. The extension of TRiP to handle antiproton beams is currently in progress. This will enable us to perform planning studies, where the potential clinical consequences can be examined, and compared to those of other beam modalities such as protons, carbon ions, or IMRT photons.
002046055 65017 $$2SzGeCERN$$aHealth Physics and Radiation Effects
002046055 693__ $$aCERN AD$$eACE AD-4
002046055 690C_ $$aARTICLE
002046055 690C_ $$aCERN
002046055 700__ $$aAlsner, Jan$$uAarhus U. Hospital
002046055 700__ $$aBeyer, Gerd$$uGeneva, Cantonal Hospital
002046055 700__ $$aDeMarco, John J.$$uUCLA, Los Angeles (main)
002046055 700__ $$aDoser, Michael$$uCERN
002046055 700__ $$aHajdukovic, Dragan$$uMontenegro U.
002046055 700__ $$aHartley, Oliver$$uGeneva, Cantonal Hospital
002046055 700__ $$aIwamoto, Keisuke S.$$uUCLA, Los Angeles (main)
002046055 700__ $$aJakel, Oliver$$uDeutsches Krebsforsch., Heidelberg
002046055 700__ $$aKnudsen, Helge V.$$uAarhus U., ISA$$uAarhus U.
002046055 700__ $$aKovacevic, Sandra$$uAarhus U. Hospital
002046055 700__ $$aMøller, Søren Pape$$uAarhus U., ISA
002046055 700__ $$aOvergaard, Jens$$uAarhus U. Hospital
002046055 700__ $$aPetersen, Jørgen B.à$$uAarhus U. Hospital
002046055 700__ $$aSolberg, Timothy D.$$uNebraska U.
002046055 700__ $$aSørensen, Brita S.$$uAarhus U. Hospital
002046055 700__ $$aVranjes, Sanja$$uNebraska U.
002046055 700__ $$aWouters, Bradly G.$$uMaastricht U.
002046055 700__ $$aHolzscheiter, Michael H.$$uNew Mexico U.
002046055 710__ $$gACE Collaboration
002046055 773__ $$c14-19$$n1$$pRadiother. Oncol.$$v86$$y2008
002046055 916__ $$sh$$w201530
002046055 960__ $$a13
002046055 980__ $$aARTICLE