001606784 001__ 1606784
001606784 003__ SzGeCERN
001606784 005__ 20220810220422.0
001606784 0247_ $$2DOI$$a10.1093/jrr/rrt050
001606784 0248_ $$aoai:cds.cern.ch:1606784$$pcerncds:FULLTEXT$$pcerncds:CERN:FULLTEXT$$pcerncds:CERN
001606784 041__ $$aeng
001606784 100__ $$aBöhlen, T T$$uKarolinska Inst., Stockholm$$uStockholm U.$$uCERN
001606784 245__ $$aA Monte Carlo-based treatment-planning tool for ion beam therapy
001606784 260__ $$c2013
001606784 520__ $$aIon beam therapy, as an emerging radiation therapy modality, requires continuous efforts to develop and improve tools for patient treatment planning (TP) and research applications. Dose and fluence computation algorithms using the Monte Carlo (MC) technique have served for decades as reference tools for accurate dose computations for radiotherapy. In this work, a novel MC-based treatment-planning (MCTP) tool for ion beam therapy using the pencil beam scanning technique is presented. It allows single-field and simultaneous multiple-fields optimization for realistic patient treatment conditions and for dosimetric quality assurance for irradiation conditions at state-of-the-art ion beam therapy facilities. It employs iterative procedures that allow for the optimization of absorbed dose and relative biological effectiveness (RBE)-weighted dose using radiobiological input tables generated by external RBE models. Using a re-implementation of the local effect model (LEM), theMCTP tool is able to perform TP studies using ions with atomic numbers Z ≤ 8. Example treatment plans created with the MCTP tool are presented for carbon ions in comparison with a certified analytical treatment- planning system. Furthermore, the usage of the tool to compute and optimize mixed-ion treatment plans, i.e. plans including pencil beams of ions with different atomic numbers, is demonstrated. The tool is aimed for future use in research applications and to support treatment planning at ion beam facilities.
001606784 540__ $$3publication$$aCC-BY-NC-3.0$$uhttp://creativecommons.org/licenses/by-nc/3.0/
001606784 542__ $$3publication$$dThe Author(s)$$g2013
001606784 65017 $$2SzGeCERN$$aHealth Physics and Radiation Effects
001606784 690C_ $$aARTICLE
001606784 690C_ $$aCERN
001606784 700__ $$aBauer, J$$uHeidelberg Ion-Beam Therapy Center, Heidelberg$$uHeidelberg University Clinic
001606784 700__ $$aDosanjh, M$$uCERN
001606784 700__ $$aFerrari, A$$uCERN
001606784 700__ $$aHaberer, T$$uHeidelberg Ion-Beam Therapy Center, Heidelberg
001606784 700__ $$aParodi, K$$uHeidelberg Ion-Beam Therapy Center, Heidelberg$$uHeidelberg University Clinic$$uMunich U.
001606784 700__ $$aPatera, V$$uU. Rome La Sapienza
001606784 700__ $$aMairan, A$$uCNAO, Pavia
001606784 773__ $$ci77-i81$$pJ. Radiat. Res.$$v54$$y2013
001606784 8564_ $$uhttps://cds.cern.ch/record/1606784/files/i77.full2.pdf$$yOxford Univ. Press Open Access article
001606784 916__ $$sh$$w201341$$ya2013
001606784 960__ $$a13
001606784 962__ $$b2652597$$ki77-i81$$nbook
001606784 980__ $$aARTICLE