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My free omega-3 guide (the ultimate blueprint for choosing a fish oil supplement) Discover my premium podcast, The Aliquot Dr. Luc van Loon is a renowned figure in the realm of exercise science, particularly celebrated for his deep understanding of protein metabolism, resistance training, and the nuanced role of collagen supplements in sports nutrition. Our conversation is an in-depth discussion on optimal protein intake & distribution strategies for stimulating muscle protein synthesis with delightful detours into insightful discussion of un ique topics like the timing of cold-water immersion. Timestamps: (00:00) Introduction (06:00) Why do we need protein? (07:04) How the protein RDA (0.8 g/kg) was established  (11:34) Protein turnover in organs (brain, liver, etc.) (14:54) How much protein do you really need? (19:42) Recommended protein intake when dieting for weight loss (20:59) How the body adapts to higher protein (24:30) Anabolic resistance (27:29) Protein requirements for overweight & obese individuals (29:42) Gaining strength vs. muscle mass (34:04) Optimal protein distribution (37:49) 20g vs. 100g protein post-workout (Luc van Loon study) (40:45) Can evening protein consumption stimulate muscle protein synthesis overnight? (45:29) How does time-restricted feeding affect muscle protein synthesis? (51:51) Protein before vs. after exercising (53:41) How does spreading out protein intake affect hypertrophy? (56:39) Protein shakes vs. animal protein (59:42) Protein supplementation for weight loss & recomposition (1:00:58) Casein vs. whey protein for stimulating muscle protein synthesis (1:03:53) Factors that influence protein's anabolic potential (1:04:58) Raw eggs vs. cooked — what's better for hypertrophy? (1:08:51) Plant vs. animal protein (1:11:52) Plant-based protein powder (1:16:31) Whey protein isolate vs. concentrate (1:17:20) How resistance training changes the leucine threshold (1:20:31) Do high-protein diets cause atherosclerosis? (1:28:29) How muscle adapts to repeated bouts of resistance training (1:31:09) Optimal resistance training frequency (1:33:06) Advice for elderly who want to start resistance training (1:35:33) Hormonal changes & resistance training (1:40:53) Does cold water immersion blunt muscle protein synthesis? (1:50:03) Does collagen increase connective protein synthesis in muscle? (1:57:45) Signaling roles of collagen peptides (2:00:15) How hydrolyzed collagen powder affects pain perception (2:01:37) Benefits of smaller peptides in hydrolyzed collagen (2:03:41) Collagen's impact on skin health (2:07:30) Amino acids from hydrolyzed collagen powder (2:12:14) Luc's exercise routine & diet Show notes are available by clicking here Watch this episode on YouTube

My omega-3 guide on concerns like a-fib, dosage, supplement quality, oxidation, and more Discover my premium podcast, The Aliquot Join over 300,000 people and sign up for my newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more In this special solo episode of FoundMyFitness, we’re taking a deep dive into alcohol. We’ll explore the science, misconceptions, controversies, and health effects of this widely used drug. I believe that a nuanced, scientific discussion on alcohol is the best way to provide you with the information you need to make an informed decision about alcohol use. Timestamps (00:00) Introduction (08:03) What does it mean to "have a drink"? (09:39) Drinking frequency definitions (12:39) How alcohol is metabolized (18:25) Can alcoholism be inherited? (19:41) How food affects alcohol metabolism (21:40) Does age affect alcohol metabolism? (22:29) How alcohol affects nutrient absorption (27:04) How alcohol affects gut health (28:57) Alcohol elevates circulating LPS levels (31:51) Gut health & alcohol use disorders (36:30) Sick quitter & healthy user biases (39:38) How alcohol impacts the brain (43:34) Alcohol's effects on anxiety (49:56) Alcohol facilitates thiamine deficiency (51:39) Alcohol promotes brain inflammation (52:56) Dementia & Alzheimer's disease risk  (1:06:50) Is resveratrol in red wine beneficial? (1:11:28) How alcohol impacts sleep (1:19:47) Mitigating alcohol's impact on sleep  (1:22:13) Hangover symptoms & causes (1:26:33) How congeners affect hangover severity (1:27:58) Treating hangovers with fruit (1:30:40) Zinc, vitamin B3, & hangovers (1:31:41) Managing hangovers with NSAIDs (1:32:22) "Hair of the dog” for hangovers (1:32:40) Liposomal glutathione, NAC, & hangovers (1:35:56) Does ZBiotics prevent hangovers? (1:38:18) Dihydromyricetin (DHM) for hangovers (1:39:15) Exercise & sauna for treating hangovers (1:40:21) Alcohol's effect on mortality risk  (1:44:28) Alcohol consumption in Blue Zones (1:49:07) Does alcohol increase cancer risk? (2:00:43) Can quitting alcohol lower cancer risk? (2:09:46) Alcohol & cardiovascular disease (CVD) (2:23:24) Alcohol and type 2 diabetes risk (2:28:28) Alcohol's impact on your waistline (2:31:33) Why alcohol facilitates weight gain (2:34:06) How alcohol impacts reproductive health (2:44:31) Preconception alcohol risks (2:47:12) How alcohol affects testosterone in men (2:48:55) Pre-pregnancy alcohol consumption risks (2:53:17) Is red wine the healthiest option? (2:57:47) Alcohol & post-exercise recovery (3:01:34) Does alcohol "blunt your gains"? (3:04:11) The BEER-HIIT study (3:05:03) Can exercise lessen alcohol cravings? (3:12:57) Alcohol damage control tactics Show notes are available by clicking here Watch this episode on YouTube

Download the 12-Page "Omega-3 Supplementation Guide" Discover my premium podcast, The Aliquot Join over 300,000 people and sign up for my newsletter  Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more Dr. Andrew Huberman is a Stanford professor, neurobiologist, and host of the incredibly popular Huberman Lab Podcast. He’s also the guest on this episode of the FoundMyFitness podcast. Our conversation encompasses an in-depth discussion of the brain’s dopamine system and provides a toolkit for enhancing motivation and focus. Timestamps (00:00) Introduction (07:58) Dopamine's Neuromodulatory Role (09:50) Motivation vs. Reward (14:56) Dopamine as a "Wave Pool" (20:19) Minimizing Smartphone Dopamine Effects (23:53) Dangers of Effortless Dopamine Peaks (27:13) Signs of High Motivation (29:20) Dopamine Reward Prediction Error (38:21) Warm-Up Period for Focus and Motivation (42:37) Rewarding Effort (53:12) Fostering Tenacity in Kids (55:26) Visualizing Negative Outcomes (58:12) Overcoming Procrastination (1:04:12) Exercise's Impact on Dopamine (1:08:56) Cold Exposure vs. Drugs (1:10:50) Exercise Entrainment Effect (1:14:45) Dangers of Relying on Stimulants (1:22:13) Cold exposure (1:30:56) Limiting Workout Intensity (1:36:29) Anterior Midcingulate Cortex (1:38:52) Transcranial Magnetic Stimulation (1:44:49) NSDR (1:59:36) Healthy Social Media Use (2:17:33) Circadian Rhythms and Solar Light (2:27:31) Limiting Late-Night Light Effects (2:30:30) Spiking Morning Cortisol (2:33:54) Long Distance Viewing vs. Screens (2:40:27) Limiting Alcohol Intake (2:54:08) ADHD (3:03:30) Replacing ADHD Drugs with Behaviors (3:05:21) Andrew's Weekly Workout Routine (3:11:04) Andrew's Diet & Supplement Routine (3:15:21) Andrew's Experimentation with Peptides (3:20:31) Processing Negative Feedback Show notes are available by clicking here Watch this episode on YouTube

Download the 13-Page "Omega-3 Supplementation Guide" Discover my premium podcast, The Aliquot Join over 300,000 people and sign up for my newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more Today's guest, Dr. Benjamin Levine, has shown that with the right exercise protocol, people who were sedentary most of their lives could reverse up to 20 years of heart aging. Dr. Levine is one of the world's leading experts in understanding how the heart adapts under a variety of conditions, whether that's exercise, elite athleticism, or hospital bedrest. Or even highly exotic conditions, like prolonged exposure to microgravity. He is the founding director of the Institute for Exercise and Environmental Medicine at UT Southwestern in Dallas. Timestamps (00:00) Introduction (06:21) Bed rest vs. aging (11:40) Does exercise protect against long COVID? (17:14) How 12 weeks of bed rest affects heart size (18:42) Why a brand-new rubber band mimics a lifetime of endurance training (22:14) The exercise dose that preserves youthful cardiovascular structure (24:22) The exercise regimen that reversed 20 years of heart aging (28:05) What it takes to reverse vascular age by 15 years (33:29) Benefits of starting an exercise regimen in your 70s (39:17) Risks of high-intensity exercise (42:42) Balancing high-intensity & moderate-intensity training (47:39) Training for health vs. training for performance (49:58) Make exercise a part of your personal hygiene (51:01) Why does VO2 max correlate with longevity? (58:29) The 2018 JAMA study on cardiorespiratory fitness & mortality (1:04:06) How does change in fitness over time affect mortality? (1:06:19) Why exercise non-responders should consider "increasing the dose" (1:10:08) The 2 limiting factors for improving VO2 max in competitive athletes (1:17:20) Heart adaptations in purely strength-trained vs. endurance athletes (1:23:09) Why pure strength-trainers should incorporate endurance training (1:26:53) How strength training affects blood pressure (1:31:27) How exercise influences cardiac output in mitochondrial myopathy patients (1:33:25) Does CrossFit count as endurance training? (1:35:50) What's the best exercise for improving blood pressure? (1:40:57) Lifestyle strategies for treating hypertension (1:43:26) Why recovery is key to reaping the benefits of a training stimulus (1:47:22) The best indicator of being overtrained (1:54:46) Why HRV is a poor indicator of recovery (2:00:02) Why do men tend to be faster runners than women? (2:03:34) Can women achieve similar aerobic exercise benefits doing 2x less than men? (2:05:06) Are there cardiovascular benefits of HRT in women? (2:08:45) Exercise volume vs. coronary plaque calcification (2:15:35) How exercise duration & intensity affect coronary calcium levels (2:18:48) Why high exercise duration & intensity increases risk of Afib (2:26:00) Why you shouldn't become an endurance athlete to "live longer" Watch this episode on YouTube Show notes are available by clicking here

Download the 9-Page "Cognitive Enhancement Blueprint" Discover my premium podcast, The Aliquot Join over 300,000 people and sign up for my newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more I recently had the privilege of presenting at the CrossFit Health Summit, where I explored a constellation of factors contributing to longevity. In this context, I placed a special emphasis on the pivotal role of vigorous exercise throughout life. Timestamps (00:00) Introduction (03:12) Why "below normal" cardio may be a great starting point (05:07) The simple math of 45 days of life extension (per 1 mL/kg/min VO2max) (06:12) Why poor cardiovascular fitness is nearly as bad as a chronic disease (06:52) Why zone 2 training may not improve VO2 max (08:08) Protocols for improving VO2 max quickly (09:10) How to estimate VO2 max in 12 minutes; (10:07) Reversing 20 years of heart aging (12:41) Blood pressure benefits of vigorous exercise (13:29) The BDNF brain benefits of high-intensity exercise (14:05) The signaling role of lactate production by muscle (16:13) How training effortfully improves focus & attention (17:23) Anti-cancer effects of vigorous exercise (18:11) Why shear stress kills circulating tumor cells (19:00) What if you exercise in short bursts all day long? (20:06) Why "exercise snacks" are a crucial pre- and post-mealtime activity (20:49) The best ways to improve mitochondrial biogenesis (21:47) The mortality benefits of breaking up sedentary time (26:17) Why the protein RDA is too low  (29:07) Does omega-3 reduce muscle atrophy? (30:41) Why we should lift for aging and to prevent the 8% per decade decline of muscle (32:03) Is lifting heavy necessary for gaining muscle? (33:06) What the sauna has in common with exercise (34:45) Does the sauna enhance the benefits of exercise? (36:44) How heat shock proteins prevent plaque aggregation & slow muscle atrophy (38:23) Can sauna after resistance training boost hypertrophy? (39:06) Optimal sauna parameters (39:59) Comparing traditional saunas to infrared (40:59) Hot baths vs. saunas (42:19) Is EPA or DHA responsible for omega-3's effects on disuse atrophy? (43:53) Are endurance athletes at risk for cardiovascular injury? (44:57) What mechanisms are responsible for sauna's benefits? (47:08) Is a sauna temperature above 200 F too hot? (49:31) My recommended sauna temperature & duration Watch this episode on YouTube Show notes are available by clicking here

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more Discover my premium podcast, The Aliquot If you’ve been following FoundMyFitness for a while, you may remember that we have our members-only podcast, The Aliquot. I want to share a preview of our newest Aliquot episode, "The Science of Optimizing Sleep," available to everyone, not just our Premium Members. Adequate, quality sleep is essential for the body's recovery and repair, promoting optimal physical and mental health. Getting a good night's sleep can be challenging, especially in our modern world, but we can take steps to overcome those challenges. In this Aliquot, we present a mashup of our best resources on sleep, featuring insights from Dr. Matthew Walker, Dr. Satchin Panda, and me.   In this preview, we discuss:   (00:02:13) How exercise timing affects deep sleep (00:08:03) Do saunas and hot baths increase sleep-enhancing hormones? (00:12:33) Can learning and meditation boost deep sleep? (00:14:10) Do scented oils, like lavender, impact sleep? (00:14:47) The insulin-tryptophan-melatonin connection (00:19:20) Why carb-heavy meals make us sleepy In the full episode available only for Premium Members, we also discuss: Can calming music, akin to lullabies, curb pre-sleep ruminations? The effect of air quality on sleep The effect of low-level noise on sleep fragmentation Whether or not time in nature transforms sleep quality Could melatonin supplementation increase REM sleep — at the cost of decrease deep sleep? How my sauna and hot tub routine preps me for sleep Is there evidence white noise helps sleep and can calming music curb pre-sleep ruminations? The differential impact of morning vs. evening light in slow wave sleep Can adjusting our body's thermal cues unlock deeper sleep? (increase deep sleep) Improving sleep with science-backed heat therapy protocols and how my sauna and hot tub routine preps me for sleep The four pillars of sleep How much sleep is enough? (from newborns to older adults) The surprising lifestyle factors that synergize to maintain glymphatic clearance in aging brains (sleep, exercise, and omega-3s) Are modern lifestyles and "social jetlag" turning us into shift workers? Building resilience against circadian disruptions Five immediate steps to enhance sleep quality tonight How long caffeine stays in the system The effect of alcohol and marijuana on sleep, particularly REM sleep

Download the 9-Page "Cognitive Enhancement Blueprint" Discover my premium podcast, The Aliquot Join over 300,000 people and sign up for my newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more In this solo episode, I'm taking an in-depth look at magnesium – a critical yet frequently underestimated mineral in our health. Magnesium stands tall among vital nutrients for its significant role in multiple aspects of human physiology. During this podcast, we'll delve into the widespread negative health effects caused by a lack of magnesium and discuss why increasing your magnesium intake might be key to achieving optimal health. In this episode, I discuss: (00:00) Introduction (04:27) Why the effects of magnesium are far-reaching (06:47) Why athletes need at least 10-20% more magnesium than the RDA (10:54) Why magnesium deficiency & insufficiency are common (12:19) How to determine if you're getting enough magnesium (15:14) Magnesium supplements (18:17) Is magnesium threonate better at crossing the blood-brain barrier? (25:08) Why magnesium threonate shouldn't count toward your RDA goal (26:04) What magnesium supplement do I take? (26:36) The effect of stress on magnesium balance (30:15) Why the energy demands of workouts affect magnesium balance (32:56) Does magnesium supplementation improve sleep? (34:04) Why trials in the field of nutrition are often misleading (37:26) Does higher magnesium intake improve cognition? (39:07) Does magnesium have a role in preventing Alzheimer's disease? (42:09) The effect of creatine on the brain (and its relationship to magnesium) (42:42) Why magnesium may prevent excitotoxicity in the brain (43:32) Magnesium's potential for managing migraines (46:41) The role of magnesium in aging (47:39) Why magnesium deficiency impairs DNA repair (49:13) Magnesium's role in cancer prevention (51:14) Why magnesium is intertwined in genomic stability (54:04) Why we shouldn't disregard observational data in nutrition (54:52) How magnesium intake affects mortality risk and cancer (57:49) Magnesium in osteoporosis prevention (59:21) Why magnesium intake in early life affects bone accretion (1:01:06) The effect of magnesium on vitamin D metabolism (1:06:36) Does magnesium treat high blood pressure? (1:10:12) Does magnesium help manage muscle cramps? (1:12:41) Is transdermal absorption of magnesium effective? Watch this episode on YouTube Show notes are available by clicking here

Download the 9-Page "Cognitive Enhancement Blueprint" Discover my premium podcast, The Aliquot Join over 300,000 people and sign up for my newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more In today's episode, I'm bringing you along to the American Academy of Anti-Aging Medicine's Longevityfest Conference, where I had the honor of presenting a keynote last December. We'll explore some foundational yet effective tactics to enhance longevity and prevent diseases. Additionally, we'll delve into more intensive lifestyle modifications that, despite their demands, offer significant longevity benefits.   In this episode, I discuss: (00:00) Introduction (04:48) The importance of vitamin D (09:08) How vitamin D deficiency affects all-cause mortality risk (12:34) Optimal vitamin D levels & supplementation (14:20) Why magnesium deficiency impairs DNA damage repair (18:00) Dangers of inadequate omega-3 intake (20:17) The correct omega-3 index level (24:42) How to correct vitamin D, omega-3, & magnesium inadequacies (26:27) Vigorous exercise is the best longevity drug (28:00) How increasing VO2 max affects life expectancy (32:46) Protocols for increasing VO2 max (35:37) How to measure VO2 max (36:44) What it takes to reverse 20 years of heart aging (39:41) Blood pressure benefits of vigorous exercise (40:58) The BDNF brain benefits of vigorous exercise (44:08) How vigorous intensity exercise improves focus & attention (45:21) Exercise protocols for maximizing BDNF (46:23) Anti-cancer effects of vigorous exercise (48:40) The benefits of exercise snacks ​ Watch this episode on YouTube Show notes are available by clicking here  

Download the 9-Page "Cognitive Enhancement Blueprint" Discover my premium podcast The Aliquot Show notes are available by clicking here Peter Attia, MD is a highly respected expert in preventive medicine, focused on the crucial subject of longevity and cardiovascular health. He's also the author of the NY Times best selling book Outlive - which I highly recommend if you have not read it already. Peter's philosophy transcends the conventional goal of merely extending lifespan; it's about enriching the quality of every year, ensuring that each stage of life is lived with optimal health and vitality. In this episode, we discuss: (00:00) Introduction (07:36) Defining cardiovascular disease (09:43) Coronary plaque and fatality risk (13:34) How ApoB predicts heart disease (21:34) Factors elevating ApoB (27:23) Does high ApoB cause cardiovascular disease (37:01) ApoB thresholds for ASCVD prevention (40:27) Dietary factors raising ApoB (49:33) Genetics of ApoB and LDL (53:24) Does low LDL increase cancer? (56:19) Cholesterol-lowering drugs (59:59) Statins, uses, and side effects (1:03:12) Are statins toxic to mitochondria? (1:09:56) Ubiquinol for statin-induced muscle soreness (1:11:09) How to train in zone 2 (1:17:09) Statins and neurodegenerative disease risk (1:21:54) Cholesterol synthesis in the brain (desmosterol role) (1:25:58) Statin alternatives (1:36:49) Berberine for CVD Risk Reduction? (1:39:36) Muscle as a glucose sink (1:51:38) Hemoglobin A1C Levels and Mortality Data (1:55:35) 80/20 Zone 2/VO2 Max Training Protocol (2:02:12) Insights from VO2 max testing data (2:12:17) How obesity increases cancer risk (2:15:03) Cancer screening (2:40:32) Menopause – hormonal shifts and health effects (2:45:13) Hormone replacement therapy (HRT) (2:58:57) Perimenopause diagnosis with hormone levels (3:02:04) HRT's impact on dementia, cancer, and heart disease risk (3:07:42) Vitamin D (3:16:24) Testosterone replacement for women's sexual function (3:18:47) HRT safety 10 years post-menopause (3:23:05) Testosterone & TRT (3:32:33) Blood pressure (3:45:30) Peter's longevity optimization routines Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/premium

Download the 9-Page "Cognitive Enhancement Blueprint" companion guide at bdnfprotocols.com. This episode challenges common perceptions about exercise, delving deep into the benefits of vigorous exercise for not just physical health but also brain function, aging, and even cancer prevention. It tackles fundamental questions, like what genetic and metabolic adaptations occur with vigorous exercise and how it can contribute to combating heart's age-related changes. We also unpack how these rigorous exercises affect glucose transport, mitochondrial health, and brain health at an intricate level. Lastly, it introduces practical applications like the Norwegian 4x4 interval training protocol, the benefits of "exercise snacks," and how to incorporate vigorous-intensity exercise into everyday life. In this episode, I discuss: (00:00) Introduction (04:34) What differentiates "vigorous" from "zone 2" training (08:34) Ties between VO2 max & life expectancy (11:55) Why zone 2 training doesn't guarantee VO2 max improvements (14:17) How to balance zone 2 training & vigorous-intensity workouts (16:17) Why the Norwegian 4x4 protocol may improve your VO2 max (19:35) Evidence-based methods to estimate VO2 max outside a lab. (22:33) What it takes to reverse 20 years of heart aging: a two-year protocol (28:24) HIIT and type 2 diabetes – how vigorous exercise can reduce risk. (29:38) The mitochondria argument: HIIT vs. Zone 2 – which intensity is better? (32:09) Rethinking the 80-20 rule for everyday exercisers (less zone 2, more effort) (35:18) The role of high-intensity workouts in enhancing mitophagy (38:03) Why lactate accumulation from higher training intensity benefits the brain (40:28) Why the "glucose sparing" effect of lactate benefits brain injury and aging (43:26) The unique BDNF benefits of high-intensity exercise: the lactate advantage (44:42) The angiogenic effects of VEGF on the blood-brain barrier (in response to lactate) (46:58) The greater the exercise intensity, the greater the myokine release (49:48) How physical activity affects death risk in breast & colorectal cancer survivors (50:56) How vigorous aerobic exercise kills circulating tumor cells (52:36) Why exercise reduces depression and neurotoxicity (kynurenine mechanism) (54:13) The surprising power of "exercise snacks" against mortality (1:01:36) Download "The Cognitive Enhancement Blueprint" at bdnfprotocols.com  Watch this episode on YouTube Show notes are available by clicking here Get the latest distilled information straight to your inbox several times per month: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/premium Learn more about our premium podcast, The Aliquot: https://www.foundmyfitness.com/aliquot

This episode features Rhonda Patrick, Ph.D., and was originally recorded for the Institute for Functional Medicine's podcast, 'Pathways to Wellbeing.' This episode outlines a series of fundamental tactics you can start applying immediately to enhance cellular health, protect the nervous system, elevate mood, reduce inflammation, promote muscle and bone function, and help prevent chronic disease. In this episode, I discuss: (00:00) Introduction (01:04) Vitamin D deficiency — risks, why it's so common, & correcting with supplementation (08:20) Magnesium's critical role in DNA repair & synthesis (11:49) The best dietary sources of magnesium (13:05) Magnesium supplements: Glycinate, malate, dioxide, & citrate (14:14) Exercise staves off age-related disease (14:52) How genetic SNPs can affect vitamin D deficiency risk (20:09) Low omega-3 intake from seafood is a top-6 preventable cause of death (22:22) Why ALA's conversion into EPA & DHA is inefficient (25:15) Omega-3 index: Optimal levels & ties to increased life expectancy (28:27) How omega-3s reduce inflammation, a key driver of aging (30:39) Omega-3s protect against muscle disuse atrophy (31:38) Why avoiding fish during pregnancy is a huge mistake (34:02) Omega-3s are a low-hanging fruit for improving cardiovascular & brain health (35:46) What to look for when choosing an omega-3 supplement (39:57) Hormesis: Why intermittent stressors are beneficial (46:14) How to choose an exercise regimen (47:09) “Exercise snacks” reduce all-cause & cancer-related mortality (49:24) Brain benefits of lactate from vigorous exercise (52:23) How blood flow generated from aerobic exercise kills circulating tumor cells (54:30) Rhonda's workout regimen  (55:38) HIIT ameliorates adverse effects of sleep deprivation  (58:32) Exercise is the best longevity "drug" Watch this episode on YouTube Show notes are available by clicking here Get the latest distilled information straight to your inbox several times per month: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/premium Learn more about the premium podcast The Aliquot: https://www.foundmyfitness.com/aliquot

Dr. Martin Gibala is a muscle physiologist, professor, and kinesiology department chair at McMaster University in Hamilton, Ontario, Canada. He is best known for pioneering research on the health benefits of high-intensity interval training (HIIT) and his profound understanding of HIIT's physiological mechanisms. He is a co-author of the book "The One-Minute Workout." In this episode, we discuss: (00:00) Introduction (11:00) What is high-intensity training? (11:53) Zone 2 vs. HIIT for VO2 max — which is better? (13:22) The vital role of vigorous exercise (14:40) Why VO2 max matters for longevity (17:45) Why athletes vs. exercisers benefit from different intensity distributions (22:09) Measuring maximum heart rate and VO2 max (30:31) How the heart adapts to HIIT to increase VO2 max (35:47) Why vigorous exercise accelerates mitochondrial adaptation (40:06) Enhancing fat oxidation and mitochondrial growth with vigorous exercise (44:22) How intensive exercise boosts fat breakdown (45:56) Is high-intensity exercise better for autophagy than fasting? (55:15) Exercise snacks (57:55) Why 'choosing the stairs' reduces early death (VILPA study) (1:00:39) Protocol for VO2 max (1:05:50) The effect of HIIT on muscle fiber types (1:10:18) How aging effects muscle fibers (1:14:09) Does high-intensity training produce an "afterburn effect?" (1:16:13) Why vigorous workouts are better for BDNF and cognition (1:23:15) Anti-metastatic cancer effects (1:50:23) Wingate training vs. reHIIT — a comparison of protocols (1:55:38) Perceived exertion vs. HRmax (1:59:23) Interval walking for people with type 2 diabetes (2:01:06) Contraindications of HIIT (2:05:06) Why preconditioning reduces risks from exercise (2:10:44) Can resistance training be a type of aerobic exercise? (2:16:24) Does cardio and strength training interfere with each other? (2:18:45) How many minutes per week of high-intensity training? (2:26:58) Are there sex differences and misconceptions in high-intensity training, for women? (2:27:42) Should post-menopausal women do H.I.I.T.? (2:27:47) Does intense exercise raise cortisol? (2:34:16) Bone density and osteoarthritis (2:36:40) Atrial fibrillation risk (2:39:20) Hypoxic training and blood flow restriction (2:40:45) Tips for training with joint issues Watch this episode on YouTube Show notes are available by clicking here Join over 300,000 people and get the latest distilled information straight to your inbox several times per month: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/premium Learn more about the premium podcast The Aliquot: https://www.foundmyfitness.com/aliquot

Dr. Chris McGlory is an assistant professor at Queen's University in Kingston, Ontario, Canada. Known for his work in the field of muscle physiology and aging, Dr. McGlory's research focuses on elucidating the molecular mechanisms underlying muscle protein synthesis and degradation, with a particular emphasis on the roles that omega-3 fatty acids play in maintaining muscle health in older adults. In this episode, we discuss: (00:00) Introduction (05:50) Start of interview (13:03) Why atrophy is worse for the old than the young (15:23) Can dietary protein prevent atrophy? (17:35) Why reduced movement can insidiously mimic short-term immobilization (22:51) The disability threshold — when atrophy may actually be deadly (24:58) Does high-dose omega-3 hold the key to fighting atrophy? (5g/day) (28:35) Does omega-3 help muscle respond more optimally to low protein? (41:37) Why omega-3 must be preloaded for 4 to 6 weeks (44:20) Why omega-3 trials have conflicting results (50:16) Does omega-3 enhance strength? (52:42) Sex differences in gaining mass and strength (54:46) Improvements in gait speed and balance (muscle performance / physical performance battery) (55:49) How to act on mixed evidence — and should we? (58:17) Why omega-3 may reduce frailty in old age (1:01:59) Why the anabolic mechanisms are counterintuitive (going beyond the canonical anti-inflammatory role of omega-3) (1:07:42) Do omega-3s boost tired, dysfunctional mitochondria? (1:15:16) Why we need an "omega-3 index" for muscle (1:18:52) Why the inflammation from cancer wastes muscle (1:20:38) Does omega-3 reduce atrophy from cancer cachexia? Watch this episode on YouTube Show notes are available by clicking here Join over 300,000 people and get the latest distilled information straight to your inbox several times per month: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/premium Learn more about the premium podcast The Aliquot: https://www.foundmyfitness.com/aliquot

Heat therapy, such as using a sauna or soaking in a hot bath, may significantly improve your slow wave sleep. My latest episode delves into the fascinating intersection between exercise and passive body heating and elucidates how high energy expenditure exercise and heat exposure share nuanced mechanisms in sleep regulation. Some key aspects explored include: The surprising role of the immune system in regulating sleep through somnogenic cytokines, immune signals like IL-1B and TNF-alpha, released in response to heat stress and exercise. The interconnected nature of thermoregulation and sleep, particularly in the brain, which highlights the importance of overlapping sleep regulation and heat loss processes. This involves warm-sensing preoptic area neurons in the preoptic area of the hypothalamus, a region known to play a crucial role in sleep regulation. The intricate, bidirectional relationship between growth hormone (GH) and slow-wave sleep (SWS). With the majority of daily GH secretion occurring during the initial phase of SWS, stimulants of SWS, such as heat exposure, can result in enhanced GH secretion, establishing a strong connection between GH and sleep regulation. The varying influence of heat on growth hormone, ranging from doubling after two 20-minute sauna sessions at 80°C, to increasing its circulation up to 16-fold after two one-hour sauna sessions at 80°C. These findings highlight the potential for heat therapy and exercise with a high rate of energy expenditure to modulate slow wave sleep through the interconnected nature of thermoregulation, immunity, exercise, and hormones. By understanding and harnessing these links, individuals can potentially enhance their sleep quality and overall health and well-being. In this episode, I discuss: (00:00) - Introduction (01:06) - Increasing pre-sleep tiredness (02:06) - Effects of exercise (04:09) - How the immune system regulates sleep (05:07) - What heat and exercise have in common (06:39) - Hormonal effects of heat (06:59) - Growth hormone (09:26) - Prolactin and sleep onset (10:39) - Effect of sexual activity (12:08) - Overlap in the brain (thermoregulation vs. sleep) (12:46) - Heat protocols and tactics Watch this episode on YouTube Show notes are available by clicking here Join over 300,000 people and get the latest distilled information straight to your inbox several times per month: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/premium Learn more about the premium podcast The Aliquot: https://www.foundmyfitness.com/aliquot

Dr. Axel Montagne is a chancellor's fellow and group leader at the UK Dementia Research Institute at the University of Edinburgh Centre for Clinical Brain Sciences. His group aims to understand how, when, and where critical components of the blood-brain barrier become dysfunctional preceding dementia and in the earliest stages of age-related cognitive decline. With this knowledge, they hope to develop precise treatments targeting brain vasculature to protect brain function. More importantly his work, and that of his colleagues, provide a critical lens through which to view the contributions of vascular dysfunction (or, conversely, vascular health – if we choose to preserve it) as a critical common thread in dementia and neurodegeneration. In this episode, we discuss: (00:00) Introduction to Dr. Axel Montagne (11:44) What dementias have in common (12:42) The importance of preserving small blood vessels (in the brain) (13:38) Changes in the blood-brain barrier in aging that cause "leaking" (15:11) Predicting cognitive decline early with biomarkers – an opportunity for intervention? (16:32) Why targeting amyloid isn’t enough (18:54) The impact of the APOE4 genotype on brain vasculature (24:19) The cause of white matter damage in the brain (33:47) Why the loss of omega-3 transport affects pericytes (35:25) The role of exercise in prevention of blood-brain barrier dysfunction (35:45) Why high heart rates during exercise preserve brain function (36:49) The role of exercise in preserving vision health (40:17) Why leaky vessels damage myelin and the brain (45:31) Can you have more than one type of dementia? (47:54) Does the breakdown of the blood-brain barrier cause “type 3 diabetes"? (54:03) Why omega-3 may prevent detachment of pericytes (1:14:35) Why a hepatitis drug restored cognition in APOE4 mice (1:19:39) Why blood-brain barrier disruption results in the accumulation of amyloid-beta (1:25:14) Why lifetime hypertension increases dementia risk (1:37:13) Effects of obesity on blood-brain barrier leakage Watch this episode on YouTube Show notes are available by clicking here Join over 300,000 people and get the latest distilled information straight to your inbox several times per month: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/premium Learn more about the premium podcast The Aliquot: https://www.foundmyfitness.com/aliquot  

Dr. Brad Schoenfeld is a professor at Lehman College in the Bronx, in New York City. His research primarily focuses on muscle adaptations to strength training, muscle hypertrophy. Publishing over 300 studies in the field of exercise and sports nutrition as a scientist, Brad began his career as a competitive bodybuilder and personal trainer. In this episode, we discuss: (00:00) Introduction to Dr. Brad Schoenfeld (05:26) Why should we lift weights? (06:56) Why building bone matters (11:33) How to lift in old age (13:45) Why to lift while young (especially women) (16:21) Should children lift weights? (17:05) Does lifting stunt growth? (19:48) How to change body composition (27:22) Protein requirements (29:19) How to calculate protein needs (36:54) Protein per meal - what's the right amount? (38:18) Does time-restricted eating undermine hypertrophy? (43:19) Anabolic window: myths vs. reality (46:15) Total daily protein intake (54:49) Why aging affects muscle power (loss of type II fibers) (57:52) Power training vs. strength (59:20) Benefits of explosive power training (fall prevention) (1:03:18) How to power train with plyometrics (1:03:58) Training to failure (is it important?) (1:09:59) Rest in between sets (is it needed?) (1:11:12) Number of sets per week (1:22:31) Tips for recovery (1:33:41) Should you get sore from exercise? (1:36:47) What can you do for soreness? (without blunting hypertrophy) (1:40:16) Does aerobic exercise undermine resistance training? (1:44:46) Resistance training for endurance athletes (1:46:33) Can stretching increase muscle growth? (1:51:06) Is yoga a type of resistance training? (1:53:37) Blood-flow restriction training (1:58:37) What is Brad's routine? Watch this episode on YouTube Show notes are available by clicking here Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/premium Learn more about the premium podcast The Aliquot: https://www.foundmyfitness.com/aliquot

George Church, Ph.D. is a professor of genetics at Harvard Medical School and of health sciences and technology at both Harvard and the Massachusetts Institute of Technology. Dr. Church played an instrumental role in the Human Genome Project and is widely recognized as one of the premier scientists in the fields of gene editing technology and synthetic biology.  In this episode, we discuss: (00:00) Introduction to Dr. George Church (07:13) History of the Human Genome Project (15:20) Manufacturing cell phones (with biology) (17:34) Genome Project-Write (20:03) Writing a human Y chromosome (from scratch) (20:48) What if you could eliminate viral disease? (22:51) De-extinction and reinstating lost traits and genes (27:06) The Vertebrate Genomes Project (29:47) AlphaFold and other AI tools (41:27) CRISPR vs. Base Editing (emerging tools of genetic engineering) (49:40) Why multiplex editing will change the world (52:18) Molecular flight recorder (53:31) Preventing viral spillover and enhancing livestock (57:40) PCSK9 gene therapy for cholesterol (1:00:30) Is aging an evolved program? (1:05:21) Treating aging with a combination gene treatment (1:09:04) Does animal research help us understand human aging? (1:11:40) Human organoids as a model and therapeutic (1:13:34) Could engineered transplant organs become better than the originals? (1:16:17) Embryo editing controversy (1:28:41) Gene editing for space travel (1:30:40) Can synthetic biology alleviate poverty? (1:34:07) Is in vitro fertilization and embryo selection practically similar to editing? (1:39:12) The occasional cost of brilliance (1:45:45) Eradicating disease with Gene Drive (1:48:55) Technologies to solve Lyme disease (1:51:57) Dr. Church's experience with narcolepsy as a bridge to creative insights (2:00:42) Why George encoded his book in DNA Watch this episode on YouTube Show notes are available by clicking here Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/premium Learn more about the premium podcast The Aliquot: https://www.foundmyfitness.com/aliquot

Stuart Phillips, PhD, is a professor of kinesiology at McMaster University in Hamilton, Ontario, Canada, where he also serves as the director of the Physical Activity Centre of Excellence. His research centers on the roles exercise and nutrition play in influencing human skeletal muscle protein turnover and how these lifestyle factors influence body composition, especially as we age. In this episode, we discuss: (00:00) Introduction to Dr. Stuart Phillips (07:16) Why muscle is important for longevity (14:34) Is the importance of muscle mass (per se) overstated? (16:48) Is the RDA on protein too low? (19:03) Minimum vs. optimal protein intake (for athletes) (19:29) Why older adults need more protein (24:52) Caloric restriction vs. higher protein for aging (28:04) What is a catabolic crisis? (29:40) Effects of space flight on muscle (36:16) Practical tips for protein intake (39:34) Protein timing and the anabolic window (41:27) Most important factors for hypertrophy (43:57) Should we supplement leucine? (45:46) Does plant protein support hypertrophy? (56:30) Causes of anabolic resistance (58:22) What types of exercise and how much? (01:06:56) Protein and rest as tools for recovery (01:08:14) Mechanisms of muscle protein synthesis and breakdown (01:08:31) Does rapamycin inhibit hypertrophy? (01:13:07) What is Dr. Phillips doing to age well? (01:15:25) Hormonal responses to exercise (01:17:09) Sex differences in hypertrophy (01:19:38) Effect of menopause on muscle (01:20:03) Do testosterone boosters work? (01:21:56) Does growth hormone improve muscle? (01:26:30) Androgen replacement therapy (benefits vs. drawbacks) (01:31:17) Mental health benefits of exercise (01:31:54) Anti-catabolic effects of heat (01:38:19) Molecular causes of sarcopenia (01:42:35) Anti-catabolic effects of omega-3 (01:48:57) Brain and muscle effects of creatine Watch this episode on YouTube Show notes and transcript Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

The intestinal barrier serves as a gatekeeper to the human body. The loss of the health and integrity of this barrier influences multiple aspects of human health – including cardiometabolic function, neurological health, behavior, and more – in surprising and unexpected ways. One of these ways involves lipopolysaccharide, or LPS, a bacterial product that arises in the intestine, and its interaction with far distal tissues and organs via the induction of immune mediators. Dr. Rhonda Patrick was the keynote speaker for the Metabolic Health Summit, held May 5 – 8, 2022, in Santa Barbara, California. Her presentation described the role that intestinal permeability and bacterial products play in aging, inflammation, and chronic disease. In this episode, we discuss: (00:00) Introduction (08:12) Atherosclerosis (13:49) Brain (16:07) Circulating LPS and behavior (19:05) Toll-like receptors and inflammation (24:00) Factors that affect intestinal permeability (30:10) Alcohol (32:07) Gluten (35:21) Butyrate and dietary fiber (37:48) Dietary fat (42:21) Biomarkers of intestinal permeability (43:11) Omega-3 fatty acids (50:02) Q&A Show notes and video LEARN MORE: Coinciding with this release, you can now find a variety of deep resources on the FoundMyFitness website for all of the topics covered in this episode. Learn about the blood-brain barrier Learn about intestinal permeability Learn about toll-like receptors Learn about cerebral small vessel disease SUPPORT THE CHANNEL: Many of these magnificent resources exist directly as a result of our premium members. As a premium member, listeners get access to our exclusive podcast The Aliquot, monthly Q&As, a special summary of scientific research every other week called the Science Digest, and more. Sign up to become a premium member and nurture the existence of the FoundMyFitness platform. Become a member

Dr. Dominic ("Dom") D'Agostino is an expert on a wide range of topics related to metabolic health, ketosis, and ketogenic diets. As one of the world's foremost experts on the ketogenic diet, Dom has personally practiced some variation of ketogenic diet for over a decade, bringing a substantial amount of practical experience along with his anecdotes from human and animal research. In this episode, we discuss: (00:00) Introduction to Dr. Dominic D'Agostino (04:59) What is "keto” (and what it is not) (08:42) Types of ketogenic diets (15:27) Lifestyle Ketogenic Diet (26:36) Biomarkers and hyperlipidemia (29:41) Micronutrients and Supplementation (33:40) Exogenous Ketones (55:48) Optimal blood concentration of ketones (Dom's pick) (01:13:31) Exercise performance and anti-catabolic effects (01:34:37) Brain and Memory (01:42:39) Intermittent Fasting (01:51:43) Neurodegenerative Diseases (01:58:05) Migraines (02:04:17) Autoimmune diseases (02:06:15) Cancer (02:22:03) Carnivore diet (02:28:22) Dom's lifestyle habits (02:31:46) Measuring ketones Watch this episode on YouTube If you’re interested in learning more, you can read the full show notes Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor