Tumor-supresorski kandidat 2 jest protein koji je kod ljudi kodiran genom TUSC2 sa hromosoma 3.[5][6][7]

TUSC2
Identifikatori
AliasiTUSC2
Vanjski ID-jeviOMIM: 607052 MGI: 1931086 HomoloGene: 5264 GeneCards: TUSC2
Lokacija gena (čovjek)
Hromosom 3 (čovjek)
Hrom.Hromosom 3 (čovjek)[1]
Hromosom 3 (čovjek)
Genomska lokacija za TUSC2
Genomska lokacija za TUSC2
Bend3p21.31Početak50,320,027 bp[1]
Kraj50,328,251 bp[1]
Lokacija gena (miš)
Hromosom 9 (miš)
Hrom.Hromosom 9 (miš)[2]
Hromosom 9 (miš)
Genomska lokacija za TUSC2
Genomska lokacija za TUSC2
Bend9|9 F1Početak107,440,454 bp[2]
Kraj107,443,311 bp[2]
Obrazac RNK ekspresije


Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija GO:0001948, GO:0016582 vezivanje za proteine
Ćelijska komponenta mitohondrija
Biološki proces regulation of mitochondrial membrane potential
cell-cell signaling
ćelijski ciklus
chemokine (C-C motif) ligand 5 production
Ćelijska proliferacija
inflammatory response
negative regulation of interleukin-17 production
cell maturation
neutrophil-mediated killing of gram-negative bacterium
GO:1904489 regulation of reactive oxygen species metabolic process
GO:0051636 defense response to Gram-negative bacterium
interleukin-15 production
positive regulation of interleukin-10 production
Fagocitoza
natural killer cell differentiation
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_007275

NM_019742

RefSeq (bjelančevina)

NP_009206

NP_062716

Lokacija (UCSC)Chr 3: 50.32 – 50.33 MbChr 9: 107.44 – 107.44 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 110 aminokiselina, а molekulska težina 12.074 Da.[8]

1020304050
MGASGSKARGLWPFASAAGGGGSEAAGAEQALVRPRGRAVPPFVFTRRGS
MFYDEDGDLAHEFYEETIVTKNGQKRAKLRRVHKNLIPQGIVKLDHPRIH
VDFPVILYEV

Funkcija

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Ovaj gen je visoko konzervirani gen kandidat zakontolu raka pluća. Još nisu dostupne nikakve druge informacije o ovom genu.[7]

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000114383 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000010054 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Fischer WH, Schubert D (Jan 1997). "Characterization of a novel platelet-derived growth factor-associated protein". J Neurochem. 66 (5): 2213–6. doi:10.1046/j.1471-4159.1996.66052213.x. PMID 8780057. S2CID 28782367.
  6. ^ Kondo M, Ji L, Kamibayashi C, Tomizawa Y, Randle D, Sekido Y, Yokota J, Kashuba V, Zabarovsky E, Kuzmin I, Lerman M, Roth J, Minna JD (Oct 2001). "Overexpression of candidate tumor suppressor gene FUS1 isolated from the 3p21.3 homozygous deletion region leads to G1 arrest and growth inhibition of lung cancer cells". Oncogene. 20 (43): 6258–62. doi:10.1038/sj.onc.1204832. PMID 11593436.
  7. ^ a b "Entrez Gene: TUSC2 tumor suppressor candidate 2".
  8. ^ "UniProt, O75896" (jezik: engleski). Pristupljeno 6. 11. 2021.

Dopunska literatura

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