Pre-iRNK-splajsing faktor SLU7 jest protein koji je kod ljudi kodiran genom SLU7 sa hromosoma 5.[5][6][7]

SLU7
Identifikatori
AliasiSLU7
Vanjski ID-jeviOMIM: 605974 MGI: 2385598 HomoloGene: 4690 GeneCards: SLU7
Lokacija gena (čovjek)
Hromosom 5 (čovjek)
Hrom.Hromosom 5 (čovjek)[1]
Hromosom 5 (čovjek)
Genomska lokacija za SLU7
Genomska lokacija za SLU7
Bend5q33.3Početak160,401,641 bp[1]
Kraj160,421,711 bp[1]
Lokacija gena (miš)
Hromosom 11 (miš)
Hrom.Hromosom 11 (miš)[2]
Hromosom 11 (miš)
Genomska lokacija za SLU7
Genomska lokacija za SLU7
Bend11|11 B1.1Početak43,324,571 bp[2]
Kraj43,338,808 bp[2]
Ontologija gena
Molekularna funkcija pre-mRNA 3'-splice site binding
second spliceosomal transesterification activity
vezivanje iona metala
GO:0001948, GO:0016582 vezivanje za proteine
nucleic acid binding
vezivanje iona cinka
Ćelijska komponenta citoplazma
nuclear speck
catalytic step 2 spliceosome
membrana
intracellular membrane-bounded organelle
small nuclear ribonucleoprotein complex
spliceosomal complex
jedro
nukleoplazma
citosol
Biološki proces cellular response to heat
RNA splicing, via transesterification reactions
mRNA processing
mRNA 3'-splice site recognition
Prerada RNK
intracellular protein transport
Alternativna prerada RNK
RNA export from nucleus
mRNA splicing, via spliceosome
mRNA export from nucleus
mRNA 3'-end processing
termination of RNA polymerase II transcription
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_006425

NM_148673
NM_198936

RefSeq (bjelančevina)
NP_006416
NP_001351446
NP_001351447
NP_001351449
NP_001351450

NP_001351451
NP_001351452

NP_683514
NP_945174

Lokacija (UCSC)Chr 5: 160.4 – 160.42 MbChr 11: 43.32 – 43.34 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 586 aminokiselina, а molekulska težina 68.387 Da.[8]

1020304050
MSATVVDAVNAAPLSGSKEMSLEEPKKMTREDWRKKKELEEQRKLGNAPA
EVDEEGKDINPHIPQYISSVPWYIDPSKRPTLKHQRPQPEKQKQFSSSGE
WYKRGVKENSIITKYRKGACENCGAMTHKKKDCFERPRRVGAKFTGTNIA
PDEHVQPQLMFDYDGKRDRWNGYNPEEHMKIVEEYAKVDLAKRTLKAQKL
QEELASGKLVEQANSPKHQWGEEEPNSQMEKDHNSEDEDEDKYADDIDMP
GQNFDSKRRITVRNLRIREDIAKYLRNLDPNSAYYDPKTRAMRENPYANA
GKNPDEVSYAGDNFVRYTGDTISMAQTQLFAWEAYDKGSEVHLQADPTKL
ELLYKSFKVKKEDFKEQQKESILEKYGGQEHLDAPPAELLLAQTEDYVEY
SRHGTVIKGQERAVACSKYEEDVKIHNHTHIWGSYWKEGRWGYKCCHSFF
KYSYCTGEAGKEIVNSEECIINEITGEESVKKPQTLMELHQEKLKEEKKK
KKKKKKKHRKSSSDSDDEEKKHEKLKKALNAEEARLLHVKETMQIDERKR
PYNSMYETREPTEEEMEAYRMKRQRPDDPMASFLGQ

Funkcija

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Splajsing pre-iRNK događa se u dva uzastopna transesterifikacijska koraka. Protein kodiran ovim genom je faktor prerade, za koji je utvrđeno da je neophodan tokom drugog katalitskog koraka u procesu prerade pre-iRNK. Povezuje se sa splajsosomom i sadrži motiv cinkovog zgloba, koji se nalazi u drugim faktorima splajsinga i uključen je u interakcije protein-proteini protein-nukleinske kiseline.[7]

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164609 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020409 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chua K, Reed R (maj 1999). "Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing". Genes Dev. 13 (7): 841–50. doi:10.1101/gad.13.7.841. PMC 316594. PMID 10197984.
  6. ^ Shomron N, Alberstein M, Reznik M, Ast G (Mar 2005). "Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing". J Cell Sci. 118 (Pt 6): 1151–9. doi:10.1242/jcs.01720. PMID 15728250.
  7. ^ a b "Entrez Gene: SLU7 SLU7 splicing factor homolog (S. cerevisiae)".
  8. ^ "UniProt, O95391" (jezik: engleski). Pristupljeno 20. 10. 2021.

Dopunska literatura

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