Mitohondrijska peptid-deformilaza je enzim koji je kod ljudi kodiran genom PDF.[5][6][7]

PDF (gen)
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

3G5K, 3G5P

Identifikatori
AliasiPDF
Vanjski ID-jeviMGI: 1915273 HomoloGene: 69354 GeneCards: PDF
Lokacija gena (čovjek)
Hromosom 16 (čovjek)
Hrom.Hromosom 16 (čovjek)[1]
Hromosom 16 (čovjek)
Genomska lokacija za PDF (gen)
Genomska lokacija za PDF (gen)
Bend16q22.1Početak69,326,913 bp[1]
Kraj69,330,588 bp[1]
Lokacija gena (miš)
Hromosom 8 (miš)
Hrom.Hromosom 8 (miš)[2]
Hromosom 8 (miš)
Genomska lokacija za PDF (gen)
Genomska lokacija za PDF (gen)
Bend8|8 D3Početak107,771,330 bp[2]
Kraj107,775,246 bp[2]
Ontologija gena
Molekularna funkcija hydrolase activity
vezivanje iona metala
peptide deformylase activity
Ćelijska komponenta mitohondrija
Biološki proces peptidyl-methionine modification
N-terminal protein amino acid modification
Biosinteza bjelančevina
positive regulation of cell population proliferation
co-translational protein modification
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_022341

NM_026513

RefSeq (bjelančevina)

NP_071736

NP_080789

Lokacija (UCSC)Chr 16: 69.33 – 69.33 MbChr 8: 107.77 – 107.78 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 243 aminokiseline, a molekulska težina 27.013 Da[8].

Simboli
1020304050
MARLWGALSLWPLWAAVPWGGAAAVGVRACSSTAAPDGVEGPALRRSYWR
HLRRLVLGPPEPPFSHVCQVGDPVLRGVAAPVERAQLGGPELQRLTQRLV
QVMRRRRCVGLSAPQLGVPRQVLALELPEALCRECPPRQRALRQMEPFPL
RVFVNPSLRVLDSRLVTFPEGCESVAGFLACVPRFQAVQISGLDPNGEQV
VWQASGWAARIIQHEMDHLQGCLFIDKMDSRTFTNVYWMKVND

Također poledajte

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Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000258429 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000078931 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Giglione C, Serero A, Pierre M, Boisson B, Meinnel T (Nov 2000). "Identification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanisms". EMBO J. 19 (21): 5916–29. doi:10.1093/emboj/19.21.5916. PMC 305796. PMID 11060042.
  6. ^ Lee MD, She Y, Soskis MJ, Borella CP, Gardner JR, Hayes PA, Dy BM, Heaney ML, Philips MR, Bornmann WG, Sirotnak FM, Scheinberg DA (Oct 2004). "Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics". J Clin Invest. 114 (8): 1107–16. doi:10.1172/JCI22269. PMC 522256. PMID 15489958.
  7. ^ "Entrez Gene: PDF peptide deformylase (mitochondrial)".
  8. ^ "UniProt, Q9HBH1". Pristupljeno 8. 7. 2021.

Dopunska literatura

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Vanjski linkovi

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