Homolog B parceliranog defetinog proteina 3 jest protein koji je kod ljudi kodiran genom PARD3B sa hromosoma 2.[5][6][7]

PARD3B
Identifikatori
AliasiPARD3B
Vanjski ID-jeviMGI: 1919301 HomoloGene: 35389 GeneCards: PARD3B
Lokacija gena (čovjek)
Hromosom 2 (čovjek)
Hrom.Hromosom 2 (čovjek)[1]
Hromosom 2 (čovjek)
Genomska lokacija za PARD3B
Genomska lokacija za PARD3B
Bend2q33.3Početak204,545,475 bp[1]
Kraj205,620,162 bp[1]
Lokacija gena (miš)
Hromosom 1 (miš)
Hrom.Hromosom 1 (miš)[2]
Hromosom 1 (miš)
Genomska lokacija za PARD3B
Genomska lokacija za PARD3B
Bend1|1 C2Početak61,677,983 bp[2]
Kraj62,681,443 bp[2]
Ontologija gena
Molekularna funkcija GO:0001948, GO:0016582 vezivanje za proteine
phosphatidylinositol binding
Ćelijska komponenta membrana
Endomembranski sistem
bicellular tight junction
međućelijske veze
nukleoplazma
nuclear body
GO:0009327 makromolekulani kompleks
citoplazma
adherens junction
cell cortex
apical plasma membrane
apical junction complex
Biološki proces Ćelijska dioba
ćelijski ciklus
microtubule cytoskeleton organization
Ćelijska adhezija
GO:0034613 protein localization
establishment of cell polarity
establishment or maintenance of epithelial cell apical/basal polarity
establishment of centrosome localization
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001302769
NM_057177
NM_152526
NM_205863

NM_001081050

RefSeq (bjelančevina)

NP_001289698
NP_476518
NP_689739
NP_995585

NP_001074519

Lokacija (UCSC)Chr 2: 204.55 – 205.62 MbChr 1: 61.68 – 62.68 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Amiokiselininska sekvenca

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Dužina polipeptidnog lanca je 1 205 aminokiselina, a molekulska težina 132.494 Da.[8]

1020304050
MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHH
LEYTDGGILDPDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQS
PDAFETEVAAQLAAFKPIGGEIEVTPSALKLGTPLLVRRSSDPVPGPPAD
TQPSASHPGGQSLKLVVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDM
TRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHE
NECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV
IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQN
KSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTR
DSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELV
AMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIP
LNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQL
IAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA
ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGW
AESEVPPSPTPHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQP
ESINLKASKSMDLVPDESKVHSLAGQKSESPSKDFGPTLGLKKSSSLESL
QTAVAEVRKNDLPFHRPRPHMVRGRGCNESFRAAIDKSYDGPEEIEADGL
SDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEKEKKKEKGKLK
VKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL
REEELEKMKEERERIGAKHQELREKQARGLLDYATGAIGSVYDMDDDEMD
PNYARVNHFREPCTSANVFRSPSPPRAGPFGYPRDGHPLSPERDHLEGLY
AKVNKPYHPLVPADSGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGR
ARPSEYDLLWVPGRGPDGNAHNLRFEGMERQYASLPRGGPADPVDYLPAA
PRGLYKERELPYYPGAHPMHPPKGSYPRPTELRVADLRYPQHYPPPPAPQ
HKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQDSRQKNP
MTAAV

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116117 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052062 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hadano S, Hand CK, Osuga H, Yanagisawa Y, Otomo A, Devon RS, Miyamoto N, Showguchi-Miyata J, Okada Y, Singaraja R, Figlewicz DA, Kwiatkowski T, Hosler BA, Sagie T, Skaug J, Nasir J, Brown RH Jr, Scherer SW, Rouleau GA, Hayden MR, Ikeda JE (Oct 2001). "A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2". Nat Genet. 29 (2): 166–73. doi:10.1038/ng1001-166. PMID 11586298. S2CID 52828189.
  6. ^ Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H (Dec 2002). "PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions". Biochem Biophys Res Commun. 299 (4): 641–6. doi:10.1016/S0006-291X(02)02698-0. PMID 12459187.
  7. ^ "Entrez Gene: PARD3B par-3 partitioning defective 3 homolog B (C. elegans)".
  8. ^ "UniProt, Q8TEW8" (jezik: eng). Pristupljeno 18. 11. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura

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Vanjski linkovi

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