Aftifilin jest protein koji je kod ljudi kodiran genom AFTPH sa hromosoma 3.[5][6][7][8]

AFTPH
Identifikatori
AliasiAFTPH
Vanjski ID-jeviMGI: 1923012 HomoloGene: 9764 GeneCards: AFTPH
Lokacija gena (čovjek)
Hromosom 2 (čovjek)
Hrom.Hromosom 2 (čovjek)[1]
Hromosom 2 (čovjek)
Genomska lokacija za AFTPH
Genomska lokacija za AFTPH
Bend2p14Početak64,524,305 bp[1]
Kraj64,593,005 bp[1]
Lokacija gena (miš)
Hromosom 11 (miš)
Hrom.Hromosom 11 (miš)[2]
Hromosom 11 (miš)
Genomska lokacija za AFTPH
Genomska lokacija za AFTPH
Bend11|11 A3.1Početak20,635,084 bp[2]
Kraj20,691,589 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija clathrin binding
Ćelijska komponenta AP-1 adaptor complex
citosol
Golđijev aparat
intracellular membrane-bounded organelle
jedro
citoplazma
trans-Golgi network membrane
Biološki proces protein transport
intracellular transport
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001002243
NM_017657
NM_203437

NM_001252503
NM_001290545
NM_181411

RefSeq (bjelančevina)
NP_001002243
NP_060127
NP_982261
NP_001362898
NP_001362899

NP_001362900
NP_001362901
NP_001362902

NP_001239432
NP_001277474
NP_852076

Lokacija (UCSC)Chr 2: 64.52 – 64.59 MbChr 11: 20.64 – 20.69 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš
Aftifilinska klatrin-vezujuća kutija
Klatrinski kompleks
Identifikatori
SimbolClathrin_bdg

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 937 aminokiselina, а molekulska težina 102.200 Da.[9]

1020304050
MEPDIIRMYSSSPPPLDNGAEDDDDDEFGEFGGFSEVSPSGVGFVDFDTP
DYTRPKEEFVPSNHFMPIHEFSENVDSLTSFKSIKNGNDKDITAELSAPV
KGQSDVLLSTTSKEIISSEMLATSIDGMERPGNLNKVVEQRQNVGTLESF
SPGDFRTNMNVVHQNKQLESCNGEKPPCLEILTNGFAVLETVNPQGTDDL
DNVADSKGRKPLSTHSTEYNLDSVPSPAEEFADFATFSKKERIQLEEIEC
AVLNDREALTIRENNKINRVNELNSVKEVALGRSLDNKGDTDGEDQVCVS
EISIVTNRGFSVEKQGLPTLQQDEFLQSGVQSKAWSLVDSADNSEAIRRE
QCKTEEKLDLLTSKCAHLCMDSVKTSDDEVGSPKEESRKFTNFQSPNIDP
TEENDLDDSLSVKNGDSSNDFVTCNDINEDDFGDFGDFGSASGSTPPFVT
GTQDSMSDATFEESSEHFPHFSEPGDDFGEFGDINAVSCQEETILTKSDL
KQTSDNLSEECQLARKSSGTGTEPVAKLKNGQEGEIGHFDSVPNIQDDCN
GFQDSDDFADFSSAGPSQVVDWNAFEDEQKDSCSWAAFGDQQATESHHRK
EAWQSHRTDENIDTPGTPKTHSVPSATSKGAVASGHLQESATSVQTALLN
RLERIFEACFPSILVPDAEEEVTSLKHLLETSTLPIKTREALPESGELLD
VWTELQDIHDAHGLRYQWGGSHSNKKLLSSLGIDTRNILFTGNKKQPVIV
PMYAAGLGMLEPTKEPLKPLSAAEKIASIGQTATMSPDMNTCTSDQFQES
LPPVQFDWSSSGLTNPLDASGGSTLLNLDFFGPVDDSSSSSSTTIPGVDP
ELYELTTSKLEISTSSLKVTDAFARLMSTVEKTSTSTSRKPKREEHLSEE
AIKVIAGLPDLTFMHAKVLMFPATLTPSTSSQEKADG

Funkcija

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Aftifilin formira stabilan kompleks sa p200 i sinerginom gama.[6][7] Protein sadrži klatrinsku kutiju, sa dva identifikovana klatrin-vezujuća motiva i uključen je u promet vezikula.[10] Protein se nalazi u mnogim eukariotima.

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000119844 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049659 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mattera R, Ritter B, Sidhu SS, McPherson PS, Bonifacino JS (Feb 2004). "Definition of the consensus motif recognized by gamma-adaptin ear domains". J Biol Chem. 279 (9): 8018–28. doi:10.1074/jbc.M311873200. PMID 14665628.
  6. ^ a b Hirst J, Borner GH, Harbour M, Robinson MS (Apr 2005). "The aftiphilin/p200/gamma-synergin complex". Mol Biol Cell. 16 (5): 2554–65. doi:10.1091/mbc.E04-12-1077. PMC 1087257. PMID 15758025.
  7. ^ a b Burman JL, Wasiak S, Ritter B, de Heuvel E, McPherson PS (Apr 2005). "Aftiphilin is a component of the clathrin machinery in neurons". FEBS Lett. 579 (10): 2177–84. doi:10.1016/j.febslet.2005.03.008. PMID 15811338. S2CID 23970781.
  8. ^ "Entrez Gene: AFTPH aftiphilin".
  9. ^ "UniProt, Q6ULP2" (jezik: engleski). Pristupljeno 10. 11. 2021.
  10. ^ Lui-Roberts WW, Ferraro F, Nightingale TD, Cutler DF (decembar 2008). "Aftiphilin and gamma-synergin are required for secretagogue sensitivity of Weibel-Palade bodies in endothelial cells". Mol. Biol. Cell. 19 (12): 5072–81. doi:10.1091/mbc.E08-03-0301. PMC 2592662. PMID 18815278.

Dopunska literatura

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Vanjski linkovi

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