Hilingon an source kan Bitamina B12


[[File:Methylcobalamin tablets.jpg|right|thumb|260px|Mga tableta nin Methylcobalamin]]

{{DISPLAYTITLE:Bitamina B{{ssub|12}}}}
An '''Bitamina B<sub>12</sub>''', midbid man bilang '''kobalamina''', iyo an natutunaw sa tubig na [[bitamina]] na imbwelto sa [[metabolismo]].<ref name="Ods">{{cite web|date=6 April 2021|title=Vitamin B12: Fact Sheet for Health Professionals|url=https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/|url-status=live|access-date=24 December 2021|author=Office of Dietary Supplements|publisher=[[US National Institutes of Health]]|publication-place=Bethesda, Maryland|archive-url=https://web.archive.org/web/20211008103749/https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/|archive-date=2021-10-08|language=en}}</ref> Saro iyan sa walong [[B bitamina]]. Kinakaipuhan iyan kan mga hayop, na piggagamit iyan bilang [[Cofactor (biochemistry)|cofactor]] sa [[DNA synthesis]], asin sa [[Fatty acid metabolism|fatty acid]] asin [[amino acid metabolism]].<ref>{{cite book|title=Interrelations between Essential Metal Ions and Human Diseases|vauthors=Yamada K|publisher=Springer|year=2013|isbn=978-94-007-7499-5|veditors=Sigel A, Sigel H, Sigel RK|series=Metal Ions in Life Sciences|volume=13|pages=295–320|chapter=Cobalt: Its Role in Health and Disease|doi=10.1007/978-94-007-7500-8_9|pmid=24470095}}</ref> Importante iyan sa normal na pagtrabaho kan [[sistemang nerbyos]] sa paagi kan saiyang papel sa [[Myelinogenesis|synthesis of myelin]], asin sa [[circulatory system]] sa maturation kan [[Red blood cell|red blood cells]] sa [[bone marrow]].<ref name="Ods" /><ref name="Calderon2020" /> Dai kaipuhan kan mga tinanom an cobalamin asin carry out an reaksyon sa enzymes na bakong dependent sa saiya.<ref name="Smith2019" />

An Bitamina B<sub>12</sub> iyo an pinakakomplikadong kemikal sa gabos na mga bitamina,<ref name="lpi">{{cite web|url=http://lpi.oregonstate.edu/mic/vitamins/vitamin-B12|title=Vitamin B<sub>12</sub>|publisher=Micronutrient Information Center, Linus Pauling Institute, Oregon State University, Corvallis, OR|date=4 June 2015|access-date=5 April 2019|archive-url=https://web.archive.org/web/20191029030049/https://lpi.oregonstate.edu/mic/vitamins/vitamin-B12|archive-date=29 October 2019|url-status=live}}</ref> asin para sa mga tawo, an solamenteng bitamina na dapat na pagkuhaan nin kakanon na gikan sa hayop o gikan sa supplements.<ref name="Ods" /><ref name="Vincenti">{{cite journal|vauthors=Vincenti A, Bertuzzo L, Limitone A, D'Antona G, Cena H|title=Perspective: Practical Approach to Preventing Subclinical B12 Deficiency in Elderly Population|journal=Nutrients|volume=13|issue=6|date=June 2021|page=1913|pmid=34199569|pmc=8226782|doi=10.3390/nu13061913|url=|doi-access=free}}</ref> Solamenteng an ibang [[archaea]] asin [[bacteria]] pwedeng mag-synthesize nin bitamina B<sub>12</sub>.<ref name="Watanabe">{{cite journal|vauthors=Watanabe F, Bito T|title=Vitamin B12 sources and microbial interaction|journal=Exp Biol Med (Maywood)|volume=243|issue=2|pages=148–158|date=January 2018|pmid=29216732|pmc=5788147|doi=10.1177/1535370217746612|url=}}</ref> An kadaklan sa mga tawo 
sa [[mauswag na nasyon]]{{Failed verification|date=May 2023}} nagkukua nin sapat na B<sub>12</sub> gikan sa pagkonsumo nin [[karne]] o mga kakanon na gikan sa hayop.<ref name="Ods" /> An mga kakanon na igwa nin  bitamina B<sub>12</sub> kabali an karne, [[Clam|clams]], [[Katoy (kakanon)|katoy]], sira, [[poultry]], [[Sugok bilang kakanon|sugok]], asin [[Dairy product|dairy products]].<ref name="Ods" /> Many [[Breakfast cereal|breakfast cereals]] are [[Food fortification|fortified]] with the vitamin.<ref name="Ods" /> [[Dietary supplement|Supplements]] and medications are available tanganing bulongon asin ebitaran an [[kakulangan sa Bitamina B12|bitamina B<sub>12</sub> deficiency]].<ref name="Ods" /> Sinda pigkukua sa paagi kan nguso, alagad para sa pagbulong kan kakulangan posibleng itao bilang [[intramuscular injection]].<ref name="Ods" /><ref name="lpi" />

An Bitamina B<sub>12</sub> nadiskubre bilang sarong resulta kan pernicious anemia, an [[autoimmune disorder]] kun saen an dugo igwa nin hababa sa normal na bilang nin pulang selula kan dugo, huli sa kakulangan nin bitamina B<sub>12</sub>.<ref name="Smith2019" /><ref>{{Cite web|title=Pernicious anemia: MedlinePlus Medical Encyclopedia|url=https://medlineplus.gov/ency/article/000569.htm|access-date=2022-01-06|website=medlineplus.gov|language=en}}</ref> The ability to absorb the vitamin declines with age, especially in people over 60 years old.<ref>{{cite journal|vauthors=Baik HW, Russell RM|title=Vitamin B12 deficiency in the elderly|journal=Annual Review of Nutrition|volume=19|pages=357–377|date=2021-11-18|pmid=10448529|doi=10.1146/annurev.nutr.19.1.357}}</ref> {{TOC limit}}

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