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Benchmarking of FLUKA production cross sections of positron emission tomography isotopes for in-vivo range verification in hadron therapy
/ Aricò, Giulia (CERN) ; Battistoni, Giuseppe (INFN, Milan ; TIFPA-INFN, Trento) ; Cerutti, Francesco (CERN) ; Horst, Felix (Darmstadt, GSI ; Mittelhessen U., Giessen) ; Mairani, Andrea (HITS, Heidelberg ; pavia cnao) ; Schuy, Christoph (Darmstadt, GSI) ; Weber, Uli (Darmstadt, GSI) ; Ferrari, Alfredo (CERN)
Protons and carbon ions have been extensively used for radiotherapy treatments, and in comparison to conventional radiotherapy, they allow a more conformal dose to the target tumor, especially in case of deep-seated tumors. However, the accuracy of hadron therapy treatments is affected by uncertainties in the particle range calculations. [...]
2020 - 4 p.
- Published in : EPJ Web Conf. 239 (2020) 24001
In : International Conference on Nuclear Data for Science and Technology (ND 2019), Beijing, China, 19 - 24 May 2019, pp.24001
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Measurement of PET isotope production cross sections for protons and carbon ions on carbon and oxygen targets for applications in particle therapy range verification
/ Horst, Felix (Darmstadt, GSI ; Mittelhessen U., Giessen) ; Adi, Wihan (Mittelhessen U., Giessen ; Giessen U.) ; Aricò, Giulia (CERN) ; Brinkmann, Kai-Thomas (Giessen U.) ; Durante, Marco (Darmstadt, GSI ; Darmstadt, Tech. U.) ; Reidel, Claire-Anne (Darmstadt, GSI ; Strasbourg, IPHC) ; Rovituso, Marta (TIFPA-INFN, Trento ; Unlisted, NL) ; Weber, Uli (Darmstadt, GSI) ; Zaunick, Hans-Georg (Giessen U.) ; Zink, Klemens (Frankfurt U., FIAS ; Mittelhessen U., Giessen ; U. Hospital, Giessen-Marburg) et al.
Measured cross sections for the production of the PET isotopes , and from carbon and oxygen targets induced by protons (40–220 ) and carbon ions (65–430 ) are presented. These data were obtained via activation measurements of irradiated graphite and beryllium oxide targets using a set of three scintillators coupled by a coincidence logic. [...]
2019 - 16 p.
- Published in : Phys. Med. Biol. 64 (2019) 205012
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Developments of the nuclear reaction and fragmentation models in FLUKA for ion collisions at therapeutic energies
/ Aricò, G (CERN) ; Ferrari, A (CERN) ; Horst, F (Darmstadt, GSI ; Giessen U.) ; Mairani, A (HITS, Heidelberg) ; Reidel, C A (Darmstadt, GSI ; U. Strasbourg) ; Schuy, C (Darmstadt, GSI) ; Weber, U (Darmstadt, GSI)
Protons and carbon ions have been used for decades in several institutes worldwide for cancer treatments. The treatment planning systems rely on accurate modeling of the nuclear reaction and fragmentation processes that occur inside the patient's tissues. [...]
Geneva : CERN, 2019 - 6 p.
- Published in : CERN Proc.: 1 (2019) , pp. 321-326
Fulltext: PDF;
In : 15th International Conference on Nuclear Reaction Mechanisms, Varenna, Italy, 11 - 15 Jun 2018, pp.321-326
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The FLUKA code for application of Monte Carlo methods to promote high precision ion beam therapy
/ Parodi, K (Heidelberg Ion Therapy Center) ; Brons, S (Heidelberg Ion Therapy Center) ; Cerutti, F (CERN) ; Ferrari, A (CERN) ; Mairani, A (Heidelberg Ion Therapy Center ; INFN, Milan) ; Paganetti, H (Massachusetts General Hospital) ; Sommerer, F (Heidelberg Ion Therapy Center ; CERN)
Monte Carlo (MC) methods are increasingly being utilized to support several aspects of commissioning and clinical operation of ion beam therapy facilities. In this contribution two emerging areas of MC applications are outlined. [...]
2010
Published version from CERN: PDF;
In : 12th International Conference on Nuclear Reaction Mechanisms, Villa Monastero, Varenna, Italy, 15 - 19 Jun 2009, pp.509-516
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In Vivo Validation of the BIANCA Biophysical Model: Benchmarking against Rat Spinal Cord RBE Data
/ Carante, Mario P (INFN, Pavia) ; Aricò, Giulia (CERN) ; Ferrari, Alfredo (CERN) ; Karger, Christian P (Heidelberg, Inst. Radiology) ; Kozlowska, Wioletta (CERN ; Med. U. of Vienna, Spitalgasse) ; Mairani, Andrea (HITS, Heidelberg) ; Sala, Paola (INFN, Milan) ; Ballarini, Francesca (INFN, Pavia ; Pavia U.)
(1) Background: Cancer ion therapy is constantly growing thanks to its increased precision
and, for heavy ions, its increased biological effectiveness (RBE) with respect to conventional photon
therapy. The complex dependence of RBE on many factors demands biophysical modeling. [...]
2020 - 11 p.
- Published in : International Journal of Molecular Sciences 21 (2020) 3973
Fulltext from publisher: PDF;
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A porous hexagonal boron nitride powder compact for the production and release of radioactive 11C
/ Stegemann, S (Leuven U.) ; Ballof, J (CERN) ; Cocolios, T E (Leuven U.) ; Correia, J -G (CERN ; IST, Lisbon (main)) ; Dockx, K (Leuven U.) ; Poleshchuk, O (Leuven U.) ; Ramos, J P (Leuven U. ; CERN) ; Schell, J (CERN) ; Stora, T (CERN) ; Vleugels, J (Leuven U.)
A porous pre-sintered hexagonal boron nitride powder compact was recently developed as target for the production of intense $^{11}$C beams for Positron Emission Tomography-aided hadron therapy. In a previous study, this target has been characterized regarding its operational limitations. [...]
2021 - 12 p.
- Published in : J. Eur. Ceramic Soc. 41 (2021) 4086-4097
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Modelling PET Radionuclides Production in Tissue and External Targets Using Geant4
/ Amin, Tanjil (Huddersfield U.) ; Barlow, Roger (Huddersfield U.) ; Hoehr, Cornelia (TRIUMF) ; Infantino, Angelo (CERN) ; Lindsay, Clay (TRIUMF)
The Proton Therapy Facility in TRIUMF provides 74 MeV protons extracted from a 500 MeV H⁻ cyclotron for ocular melanoma treatments. During treatment, positron emitting radionuclides such as C-11, O-15 and N-13 are produced in patient tissue. [...]
CERN-ACC-2017-224.-
2017 - 4 p.
- Published in : 10.18429/JACoW-IPAC2017-THPVA130
Fulltext: PDF;
In : 8th International Particle Accelerator Conference, Copenhagen, Denmark, 14 - 19 May 2017, pp.THPVA130
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Novel imaging and quality assurance techniques for ion beam therapy : a Monte Carlo study
/ Rinaldi, I (Heidelberg, Inst. Radiology) ; Ferrari, A (CERN) ; Jäkel, O (Heidelberg, Inst. Radiology ; Heidelberg Ion Therapy Center) ; Mairani, A (Heidelberg Ion Therapy Center ; INFN, Milan) ; Parodi, K (Heidelberg Ion Therapy Center)
Ion beams exhibit a finite and well defined range in matter together with an “inverted” depth-dose profile, the so-called Bragg peak. These favourable physical properties may enable superior tumour-dose conformality for high precision radiation therapy. [...]
2010
Published version from CERN: PDF;
In : 12th International Conference on Nuclear Reaction Mechanisms, Villa Monastero, Varenna, Italy, 15 - 19 Jun 2009, pp.575-580
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