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1.
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Measurement of $^{12}$C Fragmentation Cross Sections on C, O, and H in the Energy Range of Interest for Particle Therapy Applications
/ Mattei, I ; Alexandrov, A ; Alunni Solestizi, L ; Ambrosi, G ; Argiro, S ; Bartosik, N ; Battistoni, G ; Belcari, N ; Biondi, S ; Bisogni, M G et al.
In a carbon ion treatment the nuclear fragmentation of both target and beam projectiles impacts on the dose released on the tumor and on the surrounding healthy tissues. Carbon ion fragmentation occurring inside the patient body has to be studied in order to take into account this contribution. [...]
2020 - 14 p.
- Published in : IEEE Trans. Rad. Plasma Med. Sci. 4 (2020) 269-282
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2.
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Ion charge separation with new generation of nuclear emulsion films
/ Montesi, M.C. (Naples U. ; INFN, Naples) ; Lauria, A. (Naples U. ; INFN, Naples) ; Alexandrov, A. (INFN, Naples ; Naples U. ; Natl. U. Sci. Tech., Moscow ; Lebedev Inst.) ; Solestizi, L. Alunni (INFN, Perugia ; Perugia U.) ; Giovanni, Ambrosi (INFN, Perugia) ; Argirò, S. (Turin U. ; INFN, Turin) ; Diaz, R. (Havana, CEADEN) ; Bartosik, N. (INFN, Turin) ; Battistoni, G. (INFN, Milan) ; Belcari, N. (Pisa U. ; INFN, Pisa) et al.
In hadron therapy, the accelerated ions, interacting with the body of the patient, cause the fragmentation of both projectile and target nuclei. The fragments interact with the human tissues depositing energy both in the entrance channel and in the volume surrounding the tumor. [...]
2019 - 8 p.
- Published in : Open Physics 17 (2019) 233-240
Fulltext: PDF;
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3.
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Monitoring Proton Therapy Through in-Beam PET: An Experimental Phantom Study
/ Topi, A (INFN, Pisa) ; Muraro, S (INFN, Pisa) ; Battistoni, G (INFN, Milan) ; Belcari, N (INFN, Pisa ; Pisa U.) ; Bisogni, M G (INFN, Pisa ; Pisa U.) ; Camarlinghi, N (INFN, Pisa ; Pisa U.) ; Del Guerra, A (INFN, Pisa ; Pisa U.) ; Ferrari, A (CERN) ; Kopec, R (Cracow, INP) ; Kraan, A C (INFN, Pisa) et al.
In this paper, we investigate the use of a positron
emission tomography (PET) system to monitor the proton therapy. The monitoring procedure is based on the comparison
between the β+ activity generated in the irradiated volume during the treatment, with the β+ activity distribution obtained
with Monte Carlo (MC) simulation. [...]
2020 - 8 p.
- Published in : IEEE Trans. Rad. Plasma Med. Sci. 4 (2020) 194-201
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4.
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Medipix detectors in radiation therapy for advanced quality-assurance
/ Rosenfeld, Anatoly (Wollongong U.) ; Alnaghy, Saree (Wollongong U.) ; Petasecca, Marco (Wollongong U.) ; Cutajar, Dean (Wollongong U.) ; Lerch, Michael (Wollongong U.) ; Pospisil, Stanislav (Czech Tech. U., Prague) ; Giacometti, Valentina (Queen's U., Belfast) ; Schulte, Reinhard (Loma Linda U.) ; Rosso, Valeria (Pisa U. ; INFN, Pisa) ; Würl, Matthias (LMU, Munich) et al.
Spectroscopy-based photon-counting detector systems, Medipix, have many applications in medicine. Medipix detectors benefit from providing energy information as well as high spatial resolution. [...]
2020 - 18 p.
- Published in : Radiat. Meas. 130 (2020) 106211
Fulltext: PDF;
In : The Medipix/Timepix ASIC family and its applications, pp.106211
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5.
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Low statistics positron activity reconstruction methods for proton therapy
/ Muraro, S (Pisa U. ; INFN, Pisa) ; Camarlinghi, N (Pisa U. ; INFN, Pisa) ; Battistoni, G (INFN, Milan) ; Belcari, N (Pisa U. ; INFN, Pisa) ; Bisogni, M G (INFN, Pisa ; Pisa U.) ; Cristoforetti, L (Unlisted, IT) ; Del Guerra, A (Pisa U. ; INFN, Pisa) ; Ferrari, A (CERN) ; Fracchiolla, F (Unlisted, IT) ; Kraan, A (Pisa U. ; INFN, Pisa) et al.
Positron emission tomography (PET) is one of the most mature techniques for monitoring in ion beam therapy. PET allows to reconstruct the β$^{+}$ activity generated in the patient by the nuclear interaction of the ions. [...]
2019 - 2 p.
- Published in : Nucl. Instrum. Methods Phys. Res., A 936 (2019) 52-53
In : Frontier Detectors for Frontier Physics: XIV Pisa Meeting on Advanced Detectors, La Biodola, Isola D'elba, Italy, 27 May - 2 Jun 2018, pp.52-53
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6.
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The FOOT FragmentatiOn Of Target Experiment
/ Alexandrov, Andrey (INFN, Naples) ; Alpat, Behcet (INFN, Perugia) ; Ambrosi, Giovanni (INFN, Perugia) ; Argirò, Stefano (Turin U. ; INFN, Turin) ; Battistoni, Giuseppe (INFN, Milan) ; Bisogni, Maria Giuseppina (Pisa U. ; INFN, Pisa) ; Belcari, Nicola (Pisa U. ; INFN, Pisa) ; Biondi, Silvia (INFN, Bologna ; Bologna U.) ; Bruni, Graziano (INFN, Bologna) ; Camarlinghi, Niccolò (Pisa U. ; INFN, Pisa) et al.
In proton-therapy clinical practice a constant RBE equal to 1.1 is adopted, regardless of the demonstrated RBE variations, which depends on physical and biological parameters. Among other mechanisms, nuclear interactions might influence the proton-RBE due to secondary heavier particles produced by target fragmentation that can significantly contribute to the total dose: an un-wanted and undetermined increase of normal tissues complications probability may occur. [...]
Geneva : CERN, 2019 - 8 p.
- Published in : CERN Proc.: 1 (2019) , pp. 305-312
Fulltext: PDF;
In : 15th International Conference on Nuclear Reaction Mechanisms, Varenna, Italy, 11 - 15 Jun 2018, pp.305-312
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7.
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INSIDE in-beam positron emission tomography system for particle range monitoring in hadrontherapy
/ Bisogni, Maria Giuseppina (U. Pisa (main)) ; Attili, Andrea (U. Turin (main)) ; Battistoni, Giuseppe (INFN, Italy) ; Belcari, Nicola (U. Pisa (main)) ; Camarlinghi, Niccoló (U. Pisa (main)) ; Cerello, Piergiorgio (INFN, Italy) ; Coli, Silvia (INFN, Italy) ; Del Guerra, Alberto (U. Pisa (main)) ; Ferrari, Alfredo (CERN) ; Ferrero, Veronica (U. Turin (main)) et al.
The quality assurance of particle therapy treatment is a fundamental issue that can be addressed by developing reliable monitoring techniques and indicators of the treatment plan correctness. Among the available imaging techniques, positron emission tomography (PET) has long been investigated and then clinically applied to proton and carbon beams. [...]
2016 - 12 p.
- Published in : Journal of Medical Imaging 4 (2016) 011005
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8.
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Proton therapy treatment monitoring with the DoPET system: activity range, positron emitters evaluation and comparison with Monte Carlo predictions
/ Muraro, S (Pisa U. ; INFN, Pisa) ; Battistoni, G (INFN, Milan) ; Belcari, N (Pisa U. ; INFN, Pisa) ; Bisogni, M G (Pisa U. ; INFN, Pisa) ; Camarlinghi, N (Pisa U. ; INFN, Pisa) ; Cristoforetti, L (Trento Hospital, Trento) ; Guerra, A Del (Pisa U. ; INFN, Pisa) ; Ferrari, A (CERN) ; Fracchiolla, F (Trento Hospital, Trento) ; Morrocchi, M (Pisa U. ; INFN, Pisa) et al.
Ion beam irradiations can deliver conformal dose distributions minimizing damage to healthy tissues thanks to their characteristic dose profiles. Nevertheless, the location of the Bragg peak can be affected by different sources of range uncertainties: a critical issue is the treatment verification. [...]
2017 - 10 p.
- Published in : JINST 12 (2017) C12026
In : 19th International Workshop on Radiation Imaging Detectors, Krakow, Poland, 2 - 6 Jul 2017, pp.C12026
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9.
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Online monitoring for proton therapy: A real-time procedure using a planar PET system
/ Kraan, A C (Pisa U. ; INFN, Pisa) ; Battistoni, G (INFN, Milan) ; Belcari, N (Pisa U. ; INFN, Pisa) ; Camarlinghi, N (Pisa U. ; INFN, Pisa) ; Ciocca, M (CNAO, Pavia) ; Ferrari, A (CERN) ; Ferretti, S (Pisa U. ; INFN, Pisa) ; Mairani, A (CNAO, Pavia) ; Molinelli, S (CNAO, Pavia) ; Pullia, M (CNAO, Pavia) et al.
In this study a procedure for range verification in proton therapy by means of a planar in-beam PET system is presented. The procedure consists of two steps: the measurement of the β+-activity induced in the irradiated body by the proton beam and the comparison of these distributions with simulations. [...]
2015
- Published in : Nucl. Instrum. Methods Phys. Res., A 786 (2015) 120-126
Elsevier Open Access article: PDF;
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10.
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Performance of upstream interaction region detectors for the FIRST experiment at GSI
/ Abou-Haidar, Z (CNA, Seville) ; Agodi, C (INFN, LNS) ; Alvarez, M A G (CNA, Seville) ; Anelli, M (INFN, Milan) ; Aumann, T (Darmstadt, GSI) ; Battistoni, G (INFN, Milan) ; Bocci, A (CNA, Seville) ; Bohlen, T T (CERN ; Karolinska Hospital, Stockholm ; Stockholm U.) ; Boudard, A (IRFU, SPhN, Saclay) ; Brunetti, A (INFN, Cagliari ; Sassari U.) et al.
The FIRST (Fragmentation of Ions Relevant for Space and Therapy) experiment at GSI has been designed to study carbon fragmentation, measuring (12)C double differential cross sections (- (2)I /- - E) for different beam energies between 100 and 1000 MeV/u. The experimental setup integrates newly designed detectors in the, so called, Interaction Region around the graphite target. [...]
2012 - 15 p.
- Published in : JINST 7 (2012) P02006
IOP Open Access article: PDF;
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