CERN Accelerating science

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1.
Target Development towards First Production of High-Molar- Activity $^{44g}$Sc and $^{47}$Sc by Mass Separation at CERN-MEDICIS / Mamis, Edgars (CERN ; Latvia U.) ; Duchemin, Charlotte (CERN) ; Berlin, Valentina (CERN) ; Bernerd, Cyril (CERN) ; Bovigny, Mathieu (CERN) ; Chevallay, Eric (CERN) ; Crepieux, Bernard (CERN) ; Gadelshin, Vadim Maratovich (Mainz U., Inst. Phys.) ; Heinke, Reinhard (CERN) ; Hernandez, Ronaldo Mendez (CERN ; Havana, ISCTN) et al.
The radionuclides 43Sc,  44g/mSc, and 47Sc can be produced cost-effectively in sufficient yield for medical research and applications by irradiating  natTi and  natV target materials with protons. Maximizing the production yield of the therapeutic 47Sc in the highest cross section energy range of 24–70 MeV results in the co-production of long-lived, high-γ-ray-energy 46Sc and 48Sc contaminants if one does not use enriched target materials. [...]
2024 - 28 p. - Published in : Pharmaceuticals 17 (2024) 390 Fulltext: PDF;
2.
Reconditioning of the Leuven Isotope Separator as a test bench for radioactive ion beam development / Wojtaczka, Wiktoria (Leuven U.) ; Caerts, Bart (Leuven U.) ; Heines, Michael (Leuven U.) ; Johnson, Jake D (Leuven U.) ; Rothe, Sebastian (CERN) ; Cocolios, Thomas E (Leuven U.)
Producing novel medical radionuclides in the quantities necessary for pre-clinical and clinical use requires an ion source able to handle high ion throughputs, operated efficiently, to deliver high specific activity samples. This is only possible with the understanding of how different parameters affect the ion source performance. [...]
2023 - 3 p. - Published in : Nucl. Instrum. Methods Phys. Res., B 541 (2023) 399-401
In : 19th International Conference on Electromagnetic Isotope Separators and Related Topics (EMIS 2022), Daejeon, Korea, 3 - 7 Oct 2022
3.
Resonant laser ionization and mass separation of $^{225}$Ac / Johnson, Jake D (Leuven U.) ; Heines, Michael (Leuven U.) ; Bruchertseifer, Frank (Geel, JRC) ; Chevallay, Eric (CERN) ; Cocolios, Thomas E (Leuven U.) ; Dockx, Kristof (Leuven U.) ; Duchemin, Charlotte (Leuven U. ; CERN) ; Heinitz, Stephan (SCK-CEN, Mol) ; Heinke, Reinhard (Leuven U. ; CERN) ; Hurier, Sophie (Leuven U. ; SCK-CEN, Mol) et al.
$^{225}$Ac is a radio-isotope that can be linked to biological vector molecules to treat certain distributed cancers using targeted alpha therapy. However, developing $^{225}$Ac-labelled radiopharmaceuticals remains a challenge due to the supply shortage of pure $^{225}$Ac itself. [...]
2023 - 11 p. - Published in : Sci. Rep. 13 (2023) 1347 Fulltext: PDF;

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