002319802 001__ 2319802
002319802 003__ SzGeCERN
002319802 005__ 20190507203431.0
002319802 0247_ $$2DOI$$9submitter$$a10.1039/c7dt01936j
002319802 0248_ $$aoai:inspirehep.net:1673926$$pcerncds:CERN$$popenaire$$qcerncds:FULLTEXT$$qForCDS
002319802 035__ $$9http://inspirehep.net/oai2d$$aoai:inspirehep.net:1673926$$d2018-05-23T12:55:02Z$$h2018-05-24T04:00:09Z$$mmarcxml
002319802 035__ $$9Inspire$$a1673926
002319802 041__ $$aeng
002319802 100__ $$aBaum, Richard P$$uZentralklinik, Bad Berka
002319802 245__ $$9submitter$$aClinical evaluation of the radiolanthanide terbium-152: first-in-human PET/CT with $^152$Tb-DOTATOC
002319802 246__ $$9crossref$$aClinical evaluation of the radiolanthanide terbium-152: first-in-human PET/CT with 152Tb-DOTATOC
002319802 260__ $$c2017
002319802 300__ $$a9 p
002319802 520__ $$aThe existence of theragnostic pairs of radionuclides allows the preparation of radiopharmaceuticals for diagnostic and therapeutic purposes. Radiolanthanides, such as $^{177}$Lu, are successfully used for therapeutic purposes; however, a perfect diagnostic match is currently not available for clinical use. A unique, multi-disciplinary study was performed using $^{152}$Tb ($T_{1/2}$ = 17.5 h, E$\beta ^+_{average}$ = 1140 keV, I$β^+$ = 20.3%), which resulted in the first-in-human PET/CT images with this promising radionuclide. For this purpose, $^{152}$Tb was produced via a spallation process followed by mass separation at ISOLDE, CERN. The chemical separation and quality control, performed at PSI, resulted in a pure product in sufficient yields. Clinical PET phantom studies revealed an increased image noise level, because of the smaller $\beta^+$ branching ratio of $^{152}$Tb as compared to standard PET nuclides at matched activity concentrations; however, the expected recovery would be comparable at matched signal-to-noise ratios in clinical PET. $^{152}$Tb was used for labeling DOTATOC, at Zentralklinik Bad Berka, and administered to a patient for a first-in-human clinical study. PET scans were performed over a period of 24 h, allowing the visualization of even small metastases with increased tumor-to-background contrast over time. Based on the results obtained in this work, it can be deduced that PET/CT imaging with $^{152}$Tb-labeled targeting agents has promise for clinical application and may be particularly interesting for pre-therapeutic dosimetry.
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002319802 65017 $$2INSPIRE$$aOther
002319802 690C_ $$aCERN
002319802 700__ $$aSingh, Aviral$$maviral.singh@zentralklinik.de$$uZerntralklinik, Bad Berka
002319802 700__ $$aBenešová, Martina$$uPSI, Villigen$$uETH, Zurich (main)
002319802 700__ $$aVermeulen, Christiaan$$uPSI, Villigen
002319802 700__ $$aGnesin, Silvano$$uLausanne U. Hospital, Lausanne
002319802 700__ $$aKöster, Ulli$$uLaue-Langevin Inst.
002319802 700__ $$aJohnston, Karl$$uCERN
002319802 700__ $$aMüller, Dirk$$uZentralklinik, Bad Berka
002319802 700__ $$aSenftleben, Stefan$$uZentralklinik, Bad Berka
002319802 700__ $$aKulkarni, Harshad R$$uZentralklinik, Bad Berka
002319802 700__ $$aTürler, Andreas$$uPSI, Villigen$$uU. Bern (main)
002319802 700__ $$aSchibli, Roger$$uPSI, Villigen$$uETH, Zurich (main)
002319802 700__ $$aPrior, John O$$uLausanne U. Hospital, Lausanne
002319802 700__ $$avan der Meulen, Nicholas P$$uPSI, Villigen
002319802 700__ $$aMüller, Cristina$$mcristina.mueller@psi.ch$$uPSI, Villigen$$uETH, Zurich (main)
002319802 773__ $$c14638-14646$$n42$$pDalton Trans.$$v46$$y2017
002319802 8564_ $$81474855$$s2549566$$uhttps://cds.cern.ch/record/2319802/files/c7dt01936j.pdf
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002319802 960__ $$a13
002319802 980__ $$aARTICLE